Patrick Cramer

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Patrick Cramer (born February 3, 1969 in Stuttgart ) is a German chemist , structural biologist and molecular biologist .

Life

Patrick Cramer studied chemistry from 1989 to 1995 at the Universities of Stuttgart and Heidelberg . He completed part of his studies as an Erasmus scholar at the University of Bristol in Great Britain . He carried out the research for his thesis with Sir Alan Fersht in Cambridge, Great Britain, where he got to know structural biology and the Laboratory for Molecular Biology (LMB ). In 1995 he graduated from Heidelberg University with a diploma . From 1995 to 1998 Cramer was a PhD student in Christoph W. Müller's group at the European Molecular Biology Laboratory (EMBL) in Grenoble, France. In 1998 he received his doctorate in natural sciences (Dr. rer. Nat.) At the University of Heidelberg. Between 1999 and 2001 Cramer worked as a postdoctoral fellow and fellow of the German Research Foundation in the laboratory of the later Nobel Prize winner Roger D. Kornberg at Stanford University in the USA.

In 2001, Patrick Cramer returned to Germany, where he received a tenure-track professorship for biochemistry at the gene center of the Ludwig Maximilians University in Munich . There he was appointed full professor of biochemistry and head of the gene center in 2004. Cramer headed the Gene Center of the University of Munich for 10 years, from 2004 to 2013. Cramer was also at the University of Munich from 2007 to 2009 as Dean of the Faculty of Chemistry and Pharmacy, 2010 to 2013 as Director of the Department of Biochemistry, 2007 to 2013 as a member of the Research Committee and from 2008 to 2013 as spokesman for the Collaborative Research Center 464 of the German Research Foundation .

On January 1, 2014, Patrick Cramer was appointed director of the Max Planck Institute for Biophysical Chemistry in Göttingen , where he heads the "Molecular Biology" department.

Act

Patrick Cramer works primarily as a basic researcher, university lecturer and science manager. As a postdoctoral fellow at Stanford, Cramer determined the three-dimensional structure of RNA polymerase II , one of the largest enzymes in the cell nucleus . Roger Kornberg was awarded the Nobel Prize for Chemistry in 2006 for “fundamental research into the molecular basis of eukaryotic transcription”.

On the one hand, Patrick Cramer's laboratory examines the molecular mechanisms of gene transcription in eukaryotic cells. Structural biology methods are used for this purpose, in particular X-ray crystallography and cryo- electron microscopy . On the other hand, Patrick Cramer's group is researching the systemic principles of gene regulation in living cells with the help of functional genomics and bioinformatics .

Cramer's group produced the first molecularly resolved film of transcription initiation and elongation . Cramer also developed methods to analyze fundamental aspects of RNA metabolism in cells. Cramer contributes to the development of molecular systems biology by integrating approaches from molecular and systems biology. Patrick Cramer's long-term goal is to understand the expression and regulation of the genome.

In addition, Cramer is dedicated to the further development of the natural sciences in Germany and Europe. During his time in Munich he contributed to the expansion of the life sciences by co-founding the "Center for Integrated Protein Science (CIPSM)" cluster of excellence and initiating the new research building "Munich Research Center for Molecular Biosystems (BioSysM)". Cramer was also active in the scientific and technical advisory board of the Bavarian state government and in the field of bioethics at the TTN institute. He is active as an organizer of international conferences, as a reviewer and in several scientific committees and advisory boards. Since 2016 Cramer has chaired the Council of the European Molecular Biology Laboratory (EMBL).

Publications

Original research papers

  • with B. Schwalb, M. Michel, B. Zacher, K. Frühauf, C. Demel, A. Tresch and J. Gagneur: TT-seq maps the human transient transcriptome. In: Science. 352, 2016, pp. 1225-1228.
  • with C. Plaschka, M. Hantsche, C. Dienemann, C. Burzinski and J. Plitzko: Transcription initiation complex structures elucidate DNA opening. In: Nature. 533, 2016, pp. 353-358.
  • with C. Bernecky, F. Herzog, W. Baumeister and JM Plitzko: Structure of transcribing mammalian RNA polymerase II. In: Nature. 529, 2016, pp. 551-554.
  • with C. Plaschka, L. Larivière, L. Wenzeck, M. Seizl, M. Hermann, D. Tegunov, EV Petrotchenko, CH Borchers, W. Baumeister, F. Herzog and E. Villa: Architecture of the RNA polymerase II- Mediator core initiation complex. In: Nature. 518, 2015, pp. 376-380.
  • with D. Schulz, B. Schwalb, A. Kiesel, C. Baejen, P. Torkler, J. Gagneur and J. Soeding: Transcriptome Surveillance by Selective Termination of Noncoding RNA Synthesis. In: Cell. 155, 2013, pp. 1075-1087.
  • with D. Kostrewa, ME Zeller, KJ Armache, M. Seizl, K. Leike and M. Thomm: RNA polymerase II-TFIIB structure and mechanism of transcription initiation. In: Nature. 462, 2009, pp. 323-330.
  • with DA Bushnell and RD Kornberg: Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. In: Science. 292, 2001, pp. 1863-1876.
  • with DA Bushnell, J. Fu, AL Gnatt, B. Maier-Davis, NE Thompson, RR Burgess, A. Edwards, PR David and RD Kornberg: Architecture of RNA polymerase II and implications for the transcription mechanism. In: Science. 288, 2000, pp. 640-649.

Review article on research

  • with C. Plaschka and K. Nozawa: Mediator Architecture and RNA Polymerase II Interaction. In: Journal of Molecular Biology. 28, 2016, pp. 2569-2574.
  • with S. Sainsbury and C. Bernecky: Structural basis of transcription initiation by RNA polymerase II. In: Nature Reviews Molecular Cell Biology. 16, 2015, pp. 129-143.
  • A tale of chromatin and transcription in 100 structures. In: Cell. 159, 2014, pp. 985-994.
  • with AC Cheung: A Movie of RNA Polymerase II Transcription. In: Cell. 149 2012, pp. 1431-1437.
  • Deciphering the RNA polymerase II structure: a personal perspective. In: Nature Structural & Molecular Biology. 13, 2006, pp. 1042-1044.

Other publications

  • Departure into molecular systems biology. - Essay for the anniversary edition "20 years Laborjournal", Laborjournal from July 11, 2014.
  • Developments in Biomedicine: Genome Sequencing in Diagnosis, Prevention and Therapy; Systems biology and medicine. In: T. Rendtorff (Ed.): Future of Biomedical Sciences. Nomos, 2013, ISBN 978-3-8487-0849-9 .
  • with O. Primavesi, R. Hickel, TO Höllmann and W. Schön: Praise of the doctorate . In: Frankfurter Allgemeine Zeitung. 19th July 2013.
  • with J. Hacker, T. Rendtorff, M. Hallek, K. Hilpert, C. Kupatt, M. Lohse, A. Müller, U. Schroth, F. Voigt, M. Zichy: Biomedical interventions on humans - a step model to ethical Evaluation of gene and cell therapy . Walter de Gruyter, Berlin 2009, ISBN 978-3-11-021306-5 .

Awards and memberships (selection)

Web links

Individual evidence

  1. ↑ a b c d e f Leopoldina : Curriculum Vitae Patrick Cramer . Retrieved January 23, 2017.
  2. ↑ Justification of the Nobel Committee on the 2006 Nobel Prize. (PDF) Retrieved on September 19, 2016 .
  3. ^ Website of the department of Patrick Cramer at the Max Planck Institute for Biophysical Chemistry. Retrieved January 27, 2017 .
  4. ^ EMBL Council. Retrieved January 27, 2017 .
  5. ^ News from the National Academy of Sciences . Press release from the National Academy of Sciences. Retrieved April 27, 2020.
  6. ↑ https://scheringstiftung.de/de/programm/lebenswissenschaften/ernst-schering-preis/ernst-schering-preis-2019/preisverleihung-2019/
  7. ↑ Inaugural George William Jordian Lectureship. Retrieved January 4, 2019 .
  8. ^ Members Academia Europaea. Retrieved January 4, 2019 .
  9. ^ The Weigle lecture. Retrieved January 4, 2019 .
  10. ^ Biochemical Society - The Centenary Award. Retrieved January 27, 2017 .
  11. ↑ Press release on the award of the ERC Advanced Grant to Patrick Cramer. Retrieved January 27, 2017 .
  12. ↑ Laureate of the Arthur Burkhardt Foundation for Science Promotion. Retrieved January 27, 2017 .
  13. ^ Website of Patrick Cramer's laboratory at Karolinska Institutet Stockholm. Retrieved January 27, 2017 .
  14. ↑ Press release from LMU Munich on the award of the Federal Cross of Merit to Patrick Cramer. April 17, 2012. Retrieved January 27, 2017 .
  15. ^ Website for the Feldberg Foundation Prize. Retrieved September 19, 2016 .
  16. ↑ Press release from the University of Munich on the award of the ERC Advanced Grant 2010 to Patrick Cramer. December 14, 2010, accessed January 27, 2017 .
  17. ^ Website of the Bayer Foundation for the Hansen Family Prize. Retrieved January 27, 2017 .
  18. ^ List of the winners of the Ernst Jung Prize for Medicine. (No longer available online.) Archived from the original on September 19, 2016 ; Retrieved September 19, 2016 . Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.jung-stiftung.de
  19. ↑ DFG press release on the Leibniz Prize 2006. Accessed on September 19, 2016 .


personal data
SURNAME Cramer, Patrick
BRIEF DESCRIPTION German structural biologist
DATE OF BIRTH 3rd February 1969
PLACE OF BIRTH Stuttgart