Phenamidine

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Structural formula
Structure of phenamidine
General
Non-proprietary name Phenamidine
other names
  • 4,4'-oxybisbenzcarboximidamide
  • 4- (4-carbamimidoylphenoxy) benzene carboximidamide ( IUPAC )
Molecular formula C 14 H 14 N 4 O
External identifiers / databases
CAS number 101-62-2
EC number 202-960-8
ECHA InfoCard 100.002.692
PubChem 64948
Wikidata Q2085485
Drug information
ATC code

Q P51AF03

Drug class

Antiprotozoic

properties
Molar mass 254.29 g · mol -1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Phenamidine (trade name Oxopirvedine ad us. Vet) is a drug from the group of benzamidines that is used in veterinary medicine as an antiprotozoic agent against Babesia in the form of phenamidine isethionate (CAS number 620-90-6). Since the active ingredient often triggers allergic reactions , it is usually combined with an antihistamine . Phenamidine isethionate forms white, odorless crystals with a bitter taste.

Phenamidine can be used to treat babesiosis in dogs , babesiosis in horses, and babesiosis in cattle . It is hardly effective against Babesia felis . If the dosage is underdosed, resistance quickly develops .

Unwanted drug effects include swelling at the injection site and possible anaphylactic reactions, vomiting, dizziness, convulsions or liver damage. Such side effects are more common in dogs with kidney and / or liver damage. In horses, necrosis can occur after subcutaneous injection , which is why it should be administered intramuscularly in this species .

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ Janin Huebner: Babesiosis in dogs and cats . In: Veterinärspiegel 2/2002 PDF ( Memento from November 18, 2010 in the Internet Archive )

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