Ringer's solution
Ringer's solution ( Solutio Ringeri ), (modified) also Locke (-Ringer) solution ( Solutio Ringer-Locke ), is an aqueous infusion solution and is used as a fluid replacement for extracellular fluid loss in the case of isotonic dehydration (dehydration) . It also serves as a carrier solution for electrolyte concentrates or certain drugs that are administered intravenously. The Ringer solution was developed by the British physiologists Sydney Ringer (1835–1910) and Frank Spiller Locke (1871–1949) as a more physiological improvement of the “ physiological saline solution ”. The Ringer solution is the starting solution for the Balanced Salt Solutions .
properties
Variants of Ringer's solution are the Ringer's lactate solution and the Ringer's acetate solution , which contain organic anions such as lactate (anion of lactic acid ) or acetate (anion of acetic acid ) in addition to a slightly different range of electrolytes .
Ringer's lactate solution, by metabolizing lactate ions in the liver , releases hydrogen carbonate ions (HCO 3 - ), which have a buffering effect on the pH value of the blood. In the presence of mild acidosis , lactated Ringer's solution helps stabilize the pH of the blood. However, the conversion process also creates a significant additional need for oxygen in the body.
| Composition of Ringer's solution and its variants | ||||||||
|---|---|---|---|---|---|---|---|---|
| Infusion solution |
Na + ( mmol / l ) |
K + (mmol / l) |
Ca 2+ (mmol / l) |
Mg 2+ (mmol / l) |
Cl - (mmol / L) |
Lactate - (mmol / L) |
Acetate - (mmol / l) |
Theoretical osmolarity (mOsm / l) |
| Ringer's solution | 147 | 4.0 | 2.3 | - | 156 | - | - | 309 |
| Lactated Ringer's solution | 125-134 | 4.0-5.4 | 0.9-2.0 | - | 106-117 | 25-31 | - | 262-293 |
| Ringer's acetate solution | 130 | 5.4 | 0.9 | 1.0 | 112 | - | 27 | 276 |
Ringer's solution is made from sodium chloride , potassium chloride and calcium chloride by dissolving it in water for injection purposes , the variants also contain sodium hydrogen carbonate , sodium lactate or sodium acetate and magnesium chloride , depending on the case .
application
- in cleaning wounds
- it serves as a carrier solution
- to treat too little blood volume ( hypovolaemia )
- to compensate for water and electrolyte losses and to stabilize the pH value
Individual evidence
- ^ Locke-Ringer solution , in medical lexicon on Gesundheit.de
- ^ Hunnius Pharmaceutical Dictionary . 6th edition. Walter de Gruyter, Berlin / New York 1986, p. 631 ( Locke's solution ) and 902 ( Ringer's solution ).
- ^ Hunnius Pharmaceutical Dictionary . 6th edition. Walter de Gruyter, Berlin / New York 1986, p. 711 ( sodium chloride ).
- ↑ a b Technical information of the Swiss Medicines Compendium
