SRP receptor
| SR-α, SR-β | ||
|---|---|---|
| Mass / length primary structure | 909 = 638 + 271 amino acids | |
| Secondary to quaternary structure | α + β; single-pass membrane protein | |
| Identifier | ||
| Gene name (s) | SRPR , SRPRB | |
| External IDs | ||
The SRP receptor (SR, DP) , also known as docking protein , is a protein that is located in the endoplasmic reticulum in eukaryotes and on the plasma membrane in prokaryotes . It plays an important role in the protein biosynthesis of transport , membrane and export proteins. The main ligand of SR is the Signal Recognition Particle (SRP), a protein complex that binds to what is known as the signal sequence of the resulting peptide during protein synthesis , thereby stopping translation until the SRP , a G protein , binds to the SRP receptor . This interaction creates a contact between the ribosome and the translocase . The hydrolysis of GTP in the SRP and in the SRP receptor leads to a dissociation of the compound and protein biosynthesis can be continued cotranslationally in the lumen of the endoplasmic reticulum or on the plasma membrane.
The SRP receptor is a dimer of two G proteins , a peripheral α protein subunit and an integral β subunit. In prokaryotes it is only a homolog of the α-subunit.
source
- H. Kleinig, U. Maier: Cell Biology . Gustav Fischer Verlag, 1999, 4th edition, pp. 249-252, ISBN 3-437-26010-3