Semaphorin-4D
| Semaphorin-4D | ||
|---|---|---|
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| according to PDB 1OLZ | ||
| other names |
A8, BB18, GR3, CD100, Sema4D |
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| Properties of human protein | ||
| Mass / length primary structure | 862 amino acids , 96,150 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue (human) | ||
| Entrez | 10507 | |
| Ensemble | ENSG00000187764 | |
| UniProt | Q92854 | |
| Refseq (mRNA) | NM_001142287.1 | |
| Refseq (protein) | NP_001135759.1 | |
| PubMed search |
10507
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Semaphorin-4D (synonym CD100 ) is a surface protein from the group of Semaphorins .
properties
Semaphorin-4D is found in skeletal muscles , peripheral lymphocytes , spleen , thymus and, to a lesser extent, in the testes , brain , kidney , small intestine , prostate , heart , lungs , pancreas , but not in the rectum and expressed by the liver . It is a GTPase-activating protein and the receptor for PLXN1B , PLXNB2 and is involved in signal transduction between cells. Furthermore, an activation initiates the change in the actin - cytoskeleton and a polarization direction of the growth of axons a. Semaphorin-4D is also involved in the cell migration of granular cells of the cerebellum and of endothelial cells . Signal transduction takes place via Src , PTK2B / PYK2, phosphatidylinositol-3-kinase and via AKT1 . In the immune system , Semaphorin-4D is involved in the activation of T cells , the induction of antibodies and the formation of cell contacts . Semaphorin-4D binds to CD72 . It is a homodimer , glycosylated and phosphorylated .
Web links
Individual evidence
- ^ Y. Zhang, B. Liu, Y. Ma, B. Jin: Sema 4D / CD100-plexin B is a multifunctional counter-receptor. In: Cellular & Molecular Immunology. Volume 10, number 2, March 2013, pp. 97-98, doi : 10.1038 / cmi.2012.65 , PMID 23262975 , PMC 4003050 (free full text).
- ↑ Maleki KT, Cornillet M., Björkström NK: Soluble SEMA4D / CD100: A novel immunoregulator in infectious and inflammatory diseases. In: Clinical immunology. Volume 163, February 2016, pp. 52-59, doi : 10.1016 / j.clim.2015.12.012 , PMID 26732857 .
- ↑ E. Nkyimbeng-Takwi, SP Chapoval: Biology and function of neuroimmune semaphorins 4A and 4D. In: Immunologic research. Volume 50, number 1, May 2011, pp. 10-21, doi : 10.1007 / s12026-010-8201-y , PMID 21203905 , PMC 3366695 (free full text).