Somatoliberin
| Somatoliberin | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 40 amino acids | |
| Isoforms | 2 | |
| Identifier | ||
| Gene names | GHRH ; GHRF | |
| External IDs | ||
| Drug information | ||
| ATC code | H01 AC04 | |
| DrugBank | DB00010 | |
| Occurrence | ||
| Homology family | GHRH | |
| Parent taxon | Euteleostomi | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 2691 | 14601 |
| Ensemble | ENSG00000118702 | ENSMUSG00000027643 |
| UniProt | P01286 | P16043 |
| Refseq (mRNA) | NM_001184731 | NM_010285 |
| Refseq (protein) | NP_001171660 | NP_034415 |
| Gene locus | Chr 20: 37.25 - 37.26 Mb | Chr 2: 157.33 - 157.35 Mb |
| PubMed search | 2691 |
14601
|
Somatoliberin (growth hormone-releasing hormone) is a hormone formed in the hypothalamus that stimulates the formation and release of somatotropin (STH) (also growth hormone (GH)) from the anterior pituitary gland . Other names for the hormone are growth hormone releasing hormone ( GhRH , GRH), somatotropine releasing hormone ( SRH , SRF) and somatocrinin .
structure
The hormone consists of 40 amino acids . It arises through proteolytic processing from a prohormone which is 108 amino acids in size. The gene locus of the coding DNA sequence is on chromosome 20 .
Synthesis and secretion
Somatoliberin is formed in the neurosecretory cells of the ventromedial hypothalamus and in the arcuate nucleus and is released in the median eminence of the hypothalamus and reaches the adenohypophysis ( pituitary gland ) via the portal vessels, where it stimulates the somatotrophic cells to release growth hormone.
Also, pancreatic cancer can synthesize Somatoliberin and release.
effect
By binding to the growth hormone releasing hormone receptor, the hormone stimulates the synthesis and secretion of somatotropin . Furthermore, it directly favors deep sleep .
The antagonist of somatoliberin is somatostatin (SRIH).
Diseases
An excessive production of somatoliberin can lead to gigantic stature via the increased release of somatotropin, during the growth phase and after the growth phase to acromegaly .
doping
Somatoliberin is currently under discussion as a doping agent that cannot yet be detected.
Individual evidence
- ↑ Löffler, Biochemie und Pathobiochemie, 8th edition, p. 885
- ↑ a b Thorner et al .: Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. PMC 370309 (free full text)
- ^ Obal F Jr, Krueger JM .: The somatotropic axis and sleep. PMID 11924022
- ↑ RP-Online: Doping discussion in the summer of sports: New miracle drug not yet detectable ( Memento of the original from July 26th, 2009 in the Internet Archive ) Info: The archive link was inserted automatically and not yet checked. Please check the original and archive link according to the instructions and then remove this notice.
Web links
- GNRH1. In: Online Mendelian Inheritance in Man . (English).