Stephen O'Rahilly

Stephen O'Rahilly 2013

Sir Stephen Patrick O'Rahilly (* 1958 in Artane near Dublin ) is an Irish - British biochemist and endocrinologist . He is best known for his work on the genetic causes of overweight , obesity , diabetes mellitus and insulin resistance .

Live and act

O'Rahilly studied at University College Dublin . As a postdoctoral fellow he worked in London , Oxford and Harvard (among others with Robert Turner and David Weatherall ). In 1991 he got his first own laboratory at Addenbrooke's Hospital , where he took over the chair for metabolic medicine in 1996. Since 2002 he has been Professor of Clinical Biochemistry and Medicine at Cambridge University , Great Britain. Together with Nick Wareham , he heads the Institute of Metabolic Science there . In addition, O'Rahilly has directed various research facilities at Addenbrooke's Hospital and continues to work clinically there.

O'Rahilly and colleagues identified more than 20 hereditary metabolic diseases that are based on changes in individual genes . Overweight and obesity can therefore be the result of a single genetic change. O'Rahilly has shown that mutations in the leptin and melanocortin-4 receptor genes can cause obesity. Many of these genes are active in the nerve cells of the brain and regulate their activity, thereby controlling eating behavior, for example . O'Rahilly's findings have also led to new therapies; for example, leptin is used to treat lipodystrophy .

Further work by O'Rahilly deals with the hereditary causes of insulin resistance and PPARγ . He achieved many results by examining genetic abnormalities in extremely overweight people.

Awards (selection)

2002: Heinrich Wieland Prize
2003: Member of the Royal Society
2005: Rolf Luft Award from the Karolinska Institutet
2007: Prize of the Feldberg Foundation
2007: Outstanding Clinical Investigator Award from the Endocrine Society
2010: InBev-Baillet Latour Health Prize
2010: Honorary member of the German Society for Internal Medicine (DGIM)
2011: Member of the National Academy of Sciences
2013: Knight Bachelor
2013: Ulysses Medal from University College Dublin
2014: Zülch Prize
2015: EASD-Novo Nordisk Foundation Diabetes Prize for Excellence
2016: Honorary Member of the Royal Irish Academy
2019: Banting Medal of the American Diabetes Association

literature

K. Weston: Translating metabolic biochemistry into the clinic: an interview with Steve O'Rahilly. In: Disease Models & Mechanisms . 4, 2011, p. 141, doi: 10.1242 / dmm.007641 .
Ushma S. Neill: A conversation with Stephen O'Rahilly. In: Journal of Clinical Investigation . 123, 2013, p. 2335, doi: 10.1172 / JCI70726 .
Mark Hennessy: 'There are worse things in this world than being fat,' says Irish obesity expert. In: The Irish Times . April 25, 2015, accessed on May 16, 2016 .

Web links

Professor Sir Stephen O'Rahilly at the Institute of Metabolic Science at the University of Cambridge (ims.cam.ac.uk)
Professor Sir Stephen O'Rahilly at Addenbrooke's Hospital (cuh.org.uk)

Individual evidence

↑ 2002: Prof. Stephen O'Rahilly - Heinrich Wieland Prize - Homepage. In: heinrich-wieland-prize.de. November 8, 2002, accessed May 16, 2016 .
↑ Stephen O'Rahilly. In: royalsociety.org. Retrieved May 16, 2016 .
^ Rolf Luft Award. In: ki.se. December 3, 2015, accessed on May 16, 2016 .
↑ Prize Winners of the Feldberg Foundation. In: feldbergfoundation.org. March 17, 2016, accessed May 16, 2016 .
^ Outstanding Clinical Investigator Award - Endocrine Society. In: endocrine.org. Retrieved May 16, 2016 .
↑ Prix de la Santé (PDF, 625 kB) at fondsbailletlatour.com; accessed on May 16, 2016.
↑ Honorary members of the German Society for Internal Medicine (PDF, 1.0 MB); accessed on May 16, 2016.
↑ Stephen O'Rahilly. In: nasonline.org. Retrieved May 16, 2016 .
↑ Michael Stratton, cancer gene scientist, knighted - BBC News. In: bbc.com. June 14, 2013, accessed May 16, 2016 .
↑ Prof Stephen O'Rahilly. In: ucd.ie. Retrieved May 16, 2016 .
↑ Zülch price. In: mpg.de. Retrieved May 16, 2016 .
↑ Interview with Professor Sir Stephen O'Rahilly - RD-TRC. (No longer available online.) In: rd.trc.nihr.ac.uk. September 16, 2015, archived from the original on May 16, 2016 ; accessed on May 16, 2016 .
↑ Members: Stephen Patrick O'Rahilly. Royal Irish Academy, accessed May 11, 2019 .

personal data
SURNAME	O'Rahilly, Stephen
ALTERNATIVE NAMES	O'Rahilly, Stephen P.
BRIEF DESCRIPTION	Irish-British biochemist and endocrinologist
DATE OF BIRTH	1958
PLACE OF BIRTH	Artane near Dublin

[1] 2002: Prof. Stephen O'Rahilly - Heinrich Wieland Prize - Homepage. In: heinrich-wieland-prize.de. November 8, 2002, accessed May 16, 2016 .

[2] Stephen O'Rahilly. In: royalsociety.org. Retrieved May 16, 2016 .

[3] Rolf Luft Award. In: ki.se. December 3, 2015, accessed on May 16, 2016 .

[4] Prize Winners of the Feldberg Foundation. In: feldbergfoundation.org. March 17, 2016, accessed May 16, 2016 .

[5] Outstanding Clinical Investigator Award - Endocrine Society. In: endocrine.org. Retrieved May 16, 2016 .

[6] Prix de la Santé (PDF, 625 kB) at fondsbailletlatour.com; accessed on May 16, 2016.

[7] Honorary members of the German Society for Internal Medicine (PDF, 1.0 MB); accessed on May 16, 2016.

[8] Stephen O'Rahilly. In: nasonline.org. Retrieved May 16, 2016 .

[9] Michael Stratton, cancer gene scientist, knighted - BBC News. In: bbc.com. June 14, 2013, accessed May 16, 2016 .

[10] Prof Stephen O'Rahilly. In: ucd.ie. Retrieved May 16, 2016 .

[11] Zülch price. In: mpg.de. Retrieved May 16, 2016 .

[12] Interview with Professor Sir Stephen O'Rahilly - RD-TRC. (No longer available online.) In: rd.trc.nihr.ac.uk. September 16, 2015, archived from the original on May 16, 2016 ; accessed on May 16, 2016 .

[13] Members: Stephen Patrick O'Rahilly. Royal Irish Academy, accessed May 11, 2019 .