Steven L. Teitelbaum

Steven L. Teitelbaum (born June 29, 1938 in New York City ) is an American pathologist at Washington University in St. Louis . He is considered a leader in the field of osteology and osteoporosis research.

Live and act

Teitelbaum earned a bachelor's degree from Columbia University in 1960 and an MD from Washington University in St. Louis in 1964 . He completed his specialist training at Washington University and New York University . In 1968 he returned to Washington University. From 1987 to 1996 he was chief pathologist at the Barnes-Jewish Hospital in St. Louis . At Washington University he holds a professorship for pathology, immunology and internal medicine (as of early 2019) .

Teitelbaum was able to show that osteoclasts come from the hematopoietic series . He made a major contribution to the understanding of the function of osteoclasts, in particular which mechanisms mediate bone loss by osteoclasts (which enabled the development of drugs against osteoporosis) and the clinical significance of stopping bone loss from new formation (see bone remodeling ). Teitelbaum showed that the integrin α-V / integrin β-3 complex plays a central role in osteoclast function and collaborated in the development of a specific inhibitor. Further pioneering work dealt with the influence of inflammation mediators on the formation of osteoclasts, with the importance of osteoclasts in diseases that damage joints such as rheumatoid arthritis and with the nature of bone loss under therapy with glucocorticoids and its drug prevention. More recent work deals with the relationship between osteoclast activity and obesity and with the development of antidiabetic drugs that do not activate PPARγ and thus increase the risk of fractures like thiazolidinediones .

Steven L. Teitelbaum has published over 340 scientific papers . He is an editor of Cell Metabolism and Experimental Medicine. In 1992/93 he was President of the American Society for Bone and Mineral Research (ASBMR) and in 2002/03 President of the Federation of American Societies for Experimental Biology (FASEB).

In 2019, he received the International König-Faisal Prize for Medicine for his work in researching the biology of bones and in particular the function and regulation of osteoclasts and their importance for the development of osteoporosis .

Web links

• Steven Teitelbaum, MD and Teitelbaum Lab at Washington University in St. Louis (wustl.edu)
• Steven L. Teitelbaum, MD - Distinguished Service Award 2007 from Washington University in St. Louis (wustl.edu)
• Professor Steven L. Teitelbaum at kingfaisalprize.org