T-2 toxin

Structural formula
General
Surname	T-2 toxin
other names	Fusariotoxin T2
Molecular formula	C 24 H 34 O 9
Brief description	white solid
External identifiers / databases
EC number	244-297-7
ECHA InfoCard	100.040.255
PubChem	30552
ChemSpider	28354
Wikidata	Q421570
properties
Molar mass	466.52 g mol −1
Physical state	firmly
Melting point	151.5 ° C
solubility	almost insoluble in water; soluble in polar organic solvents;
safety instructions
GHS labeling of hazardous substances danger
H and P phrases	H: 300-310-315-330
	P: 260-264-280-284-302 + 350-310
Toxicological data	1.84 mg kg −1 ( LD 50 , chicken , oral ) ; 1 mg · kg -1 ( LD 50 , guinea pigs , oral ) ; 3.8 mg kg −1 ( LD 50 , mouse , oral ) ; 4 mg kg −1 ( LD 50 , pigs , oral ) ; 2.7 mg kg −1 ( LD 50 , rat , oral ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

T-2 toxin is a mycotoxin (poison from mold ) belonging to the trichothecenes group and a Fusarium toxin . It is one of the type A trichothecenes and arises as a metabolic product of fungi of various genera, mainly members of the Fusarium genus , such as Fusarium sporotrichioides and Fusarium tricinctum .

toxicology

The toxin is toxic to both mammals and birds, with oral LD ₅₀ values between 1 and 4 mg / kg body weight. In some animal species (cattle, mice, pigs) the administration caused gastric bleeding, diarrhea and drowsiness. A carcinogenic effect in various animals has been proven.

Individual evidence

↑ ^a ^b ^c ^d T-2 toxin data sheet from Sigma-Aldrich , accessed on May 9, 2011 ( PDF ).

↑ ^a ^b Entry on T-2 toxin in the ChemIDplus database of the United States National Library of Medicine (NLM)

^ Mary J. Duffy, R. Stephen Reid: Measurement of the stability of T-2 toxin in aqueous solution , In: Chemical Research in Toxicology , 1993, 6: pp. 524-529. doi : 10.1021 / tx00034a021

^ ^A ^b Journal of Agricultural and Food Chemistry . Vol. 26, p. 246, 1978.

↑ ^a ^b Developments in Food Science. Vol. 4, p. 135, 1983.

↑ ^a ^b Biotechnology and Bioengineering. Vol. 10, p. 445, 1968.

↑ ^a ^b Journal of the American Veterinary Medical Association. Vol. 163, pp.

↑ ^a ^b Developments in Food Science. Vol. 4, p. 135, 1983.

[Sigma-1] T-2 toxin data sheet from Sigma-Aldrich , accessed on May 9, 2011 ( PDF ).

[chemid-2] Entry on T-2 toxin in the ChemIDplus database of the United States National Library of Medicine (NLM)

[DuffyReid1993-3] Mary J. Duffy, R. Stephen Reid: Measurement of the stability of T-2 toxin in aqueous solution , In: Chemical Research in Toxicology , 1993, 6: pp. 524-529. doi : 10.1021 / tx00034a021

[t1-4] A ^b Journal of Agricultural and Food Chemistry . Vol. 26, p. 246, 1978.

[t2-5] Developments in Food Science. Vol. 4, p. 135, 1983.

[t3-6] Biotechnology and Bioengineering. Vol. 10, p. 445, 1968.

[t4-7] Journal of the American Veterinary Medical Association. Vol. 163, pp.

[t5-8] Developments in Food Science. Vol. 4, p. 135, 1983.