Tom Curran

from Wikipedia, the free encyclopedia

Thomas "Tom" Curran (* 1956 in Scotland ) is a British - American pathologist .

Curran earned a bachelor's degree in Life Sciences from the University of Edinburgh in 1978 and a Ph.D. at the Imperial Cancer Research Fund and University College London . He worked as a postdoctoral fellow at the Salk Institute for Biological Studies . He then worked at the Roche Institute of Molecular Biology , where he was Head of the Department of Molecular Oncology and Virology from 1991 to 1995 . From 1995 to 2006 he was the founding director of the Department of Developmental Neurobiology (see Developmental Biology and Neurobiology ) at St. Jude Children's Research Hospital . After a position (2006–2015) as deputy scientific director at the Perelman School of Medicine at the University of Pennsylvania , he is now (as of 2017) head of research at Children's Mercy Hospital in Kansas City , Missouri . He is professor of pediatrics at the University of Missouri-Kansas City and cancer research at the University of Kansas .

Curran has important contributions to make molecular oncology, including pioneering work on the importance of oncogenes c-Fos and c-Jun for the regulation of transcription . He also discovered the redox regulation of various transcription factors by Ref-1 , which is also involved in DNA repair . He identified the Reelin gene and elucidated a signaling pathway in which lipoprotein receptors and genes of the disabled-1 - and crk - family involved and the location of neurons controls during brain development. Curran developed an animal model for the rapidly growing medulloblastoma in children and showed that - at least in mice - orally available inhibitors of the Hedgehog signaling pathway (including HhAntag ) can eliminate even large tumors.

Curran has published more than 290 scientific publications , he has (as of October 2018) an h-index of 118.

Awards (selection)

Web links

Individual evidence

  1. ^ A b Royal Society elects Tom Curran as Fellow. In: eurekalert.org. June 3, 2005, accessed November 18, 2017 .
  2. ^ Tom Curran - Google Scholar Citations. In: scholar.google.com. Retrieved October 8, 2018 .
  3. ^ Recipients of the Passano Laureate and Physician Scientist Awards. In: passanofoundation.org. Retrieved May 15, 2019 .
  4. ^ AACR Award for Outstanding Achievement in Cancer Research. In: aacr.org. April 17, 2016, accessed November 19, 2017 .
  5. ↑ Curran, Tom. In: aaas.org. February 24, 2017, accessed November 18, 2017 .
  6. ^ Presidents of the AACR. In: aacr.org. November 18, 2017, accessed November 18, 2017 .
  7. ↑ Tom Curran. In: royalsociety.org. Retrieved November 18, 2017 .
  8. ↑ Book of Members 1780 – present, Chapter C. (PDF; 1.3 MB) In: American Academy of Arts and Sciences (amacad.org). Retrieved November 18, 2017 .
  9. ↑ Tom Curran, PhD. In: aacr.org. November 19, 2017, accessed November 19, 2017 .
personal data
SURNAME Curran, Tom
ALTERNATIVE NAMES Curran, Thomas
BRIEF DESCRIPTION British-American pathologist
DATE OF BIRTH 1956
PLACE OF BIRTH Scotland