Torsten Swede

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Torsten Schwede (2011)

Torsten Schwede (born October 2, 1967 in Coburg ) is a German-Swiss bioinformatician and professor at the Biozentrum of the University of Basel , Switzerland .

Life

Torsten Schwede studied chemistry at the University of Bayreuth and the Albert-Ludwigs-University in Freiburg im Breisgau. After receiving his doctorate in 1998, he went to Geneva and did research at the global pharmaceutical company GlaxoSmithKline . In 2001 Torsten Schwede was appointed assistant professor for structural and bioinformatics at the Biozentrum of the University of Basel . A year later he also became a group leader at SIB. Torsten Schwede has been Associate Professor for Structural and Bioinformatics since 2007 and teaches and researches at the Biozentrum of the University of Basel.

Act

Torsten Schwede develops methods and algorithms with which the properties of the three-dimensional structures of proteins can be modeled and thus knowledge about their function at the atomic level can be gained . His work focuses on homology modeling methods that can be used to model the structures of proteins that have not yet been experimentally elucidated . The structure of an unknown protein is interpolated on the basis of known related proteins. Torsten Schwede is developing Swiss-Model, a web server that automates the modeling of protein structures and thus greatly simplifies it. In order to be able to recognize inaccuracies in structural predictions, his group develops the QMEAN method for estimating the model quality, and organizes the CAMEO project for the independent evaluation of prediction methods as a supplement to the CASP experiment.

In addition to predicting protein structures, his group also works on the modeling of protein-ligand interactions. In silico screening , it was possible to identify new potential inhibitors against the dengue virus . Using the X-ray structure analysis of the enzyme histidine ammonia lyase (histidase), Torsten Schwede was able to identify a new type of electrophilic cofactor in enzymes that is formed by an autocatalytic modification of the protein chain becomes.

Awards

2009 ISI Thomson Reuters selects “Swiss-Model: An automated protein homology-modeling server; Nucleic Acids Res 31: 3381–3385 (2003) ”on the most cited Swiss publication of the last 10 years (1999–2009).

Publications (selection)

Complete list of publications

  • Marco Biasini, Stefan Bienert, Andrew Waterhouse, Konstantin Arnold, Gabriel Studer, Tobias Schmidt, Florian Kiefer, Tiziano Gallo Cassarino, Martino Bertoni, Lorenza Bordoli, Torsten Schwede: Swiss-Model: modeling protein tertiary and quaternary structure using evolutionary information. 2014. PMID 24782522
  • Torsten Schwede: Protein modeling: what happened to the "protein structure gap"? In: Structure. 21 (9), 2013, pp. 1531-1540. PMID 24010712
  • P. Benkert, M. Biasini, T. Schwede: Toward the estimation of the absolute quality of individual protein structure models. In: Bioinformatics. 27 (3), 2011, pp. 343-350. PMID 21134891
  • M. Podvinec, SP Lim, TB Schmidt, M. Scarsi, D. Wen, LS Sonntag, P. Sanschagrin, PS Shenkin, T. Schwede: Novel Inhibitors of Dengue Virus Methyltransferase: Discovery by in vitro-driven virtual screening on a desktop Computer grid. In: Journal of Medicinal Chemistry. 53 (4), 2010, pp. 1483-1495. PMID 20108931
  • TF Schwede, J. Retey, GE Schulz: Crystal Structure of Histidine Ammonia-Lyase Revealing a Novel Polypeptide Modification as the Catalytic Electrophile. In: Biochemistry. 38, 1999, pp. 5355-5361. PMID 10220322

Web links

Individual evidence

  1. ↑ T. Schwede, J. Kopp, N. Guex, MC Peitsch: SWISS-MODEL: An automated protein homology-modeling server. In: Nucleic acids research. Volume 31, Number 13, July 2003, pp. 3381-3385, ISSN  1362-4962 . PMID 12824332 . PMC 168927 (free full text).
  2. ↑ Protein Modeling: What Happened to the `` Protein Structure Gap ''? els-cdn.com. Retrieved June 18, 2014.
  3. ↑ Swiss-Model swissmodel.expasy.org. Retrieved June 18, 2014.
  4. ↑ QMEAN server for protein model quality estimation oxfordjournals.org. Retrieved June 18, 2014.
  5. ↑ Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid. unboundmedicine.com. Retrieved June 18, 2014.
  6. ↑ T. Schwede et al .: Crystal Structure of Histidine Ammonia-Lyase Revealing a Novel Polypeptide Modification as the Catalytic Electrophile. In: Biochemistry. 38, 1999, pp. 5355-5361, doi: 10.1021 / bi982929q .
  7. ↑ Most-Cited Paper From the Top 20 Countries, 1999-August 31, 2009. sciencewatch.com. Retrieved June 18, 2014.
  8. ↑ Complete list of publications Biozentrum.unibas.ch. Retrieved June 18, 2014.
personal data
SURNAME Swede, Torsten
ALTERNATIVE NAMES Swede, Torsten Franz (full name)
BRIEF DESCRIPTION German bioinformatician and professor at the Biozentrum of the University of Basel, Switzerland
DATE OF BIRTH October 2nd, 1967
PLACE OF BIRTH Coburg