Trifluoroacetic anhydride
Structural formula | ||||||||||||||||
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General | ||||||||||||||||
Surname | Trifluoroacetic anhydride | |||||||||||||||
other names |
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Molecular formula | C 4 F 6 O 3 | |||||||||||||||
Brief description |
colorless pungent smelling liquid |
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properties | ||||||||||||||||
Molar mass | 210.03 g mol −1 | |||||||||||||||
Physical state |
liquid |
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density |
1.51 g cm −3 |
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Melting point |
−65 ° C |
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boiling point |
40 ° C |
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Refractive index |
1.269 (25 ° C) |
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safety instructions | ||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C |
Trifluoroacetic anhydride is a low-boiling, pungent odor and colorless liquid. Trifluoroacetic anhydride is the anhydride of trifluoroacetic acid and is used as a reagent for synthesis and for derivatization in analysis .
presentation
TFAA can be made by dehydrating trifluoroacetic acid with phosphorus pentoxide . However, this method is too inefficient for a large-scale representation.
use
TFAA can be used as an anhydride for the preparation of esters and amides of trifluoroacetic acid. It is therefore a reagent for introducing the trifluoroacetyl group, which is important in pharmaceutical chemistry .
In analysis, TFAA is used as a derivatization reagent to stabilize analytes under gas chromatographic conditions or to increase their volatility.
safety instructions
TFAA is a strongly hygroscopic liquid, from which the strongly corrosive and caustic trifluoroacetic acid is formed by hydrolysis. The metal barrels for storage are therefore lined with a layer of polyethylene .
Individual evidence
- ↑ Data sheet trifluoroacetic anhydride (PDF) from Carl Roth , accessed on January 28, 2018.
- ↑ a b c d e Entry on trifluoroacetic anhydride in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .
- ↑ David R. Lide (Ed.): CRC Handbook of Chemistry and Physics . 90th edition. (Internet version: 2010), CRC Press / Taylor and Francis, Boca Raton, FL, Physical Constants of Organic Compounds, pp. 3-500.
- ↑ a b Entry stimulants from the German Sport University Cologne.
- ↑ Swarts: In Bull Sci. Acad. Roy. Belg. , 1922 , 8 , pp. 343-370.
- ↑ Patent DE60012337T2 , December 2, 2004.