Trilostane

Structural formula
General
Non-proprietary name	Trilostane
other names	(2 α , 4 α , 5 α , 17 β ) -4,5-epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile
Molecular formula	C 20 H 27 NO 3
External identifiers / databases
EC number	237-133-0
ECHA InfoCard	100.033.743
PubChem	656583
DrugBank	DB01108
Wikidata	Q907313
Drug information
ATC code	H02 CA01 ; Q H02CA01 ;
Drug class	Anticorticosteroid
Mechanism of action	Inhibition of steroid hormone synthesis
properties
Molar mass	329.43 g · mol -1
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
H and P phrases	H: 315-319-361
	P: ?
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Trilostane is the generic name of a chemical compound belonging to the steroid class that is used in veterinary medicine to treat hypophyseal hypophysis . Trilostane inhibits the 3 β -hydroxysteroid dehydrogenase enzyme system and thus competitively the synthesis of various steroid hormones (e.g. cortisol and aldosterone ) in the adrenal cortex , but is itself hormonally inactive. The drug is well tolerated and works very safely, quickly and reversibly. The side effects are significantly fewer than with mitotane .

The biotransformation takes place in the liver . The plasma half-life is eight hours.

It is used to treat Cushing's Syndrome in dogs and horses ( Equines Cushing's Syndrome , ECS) and Alopecia X in some breeds of dogs.

Trade names

Modrenal, Vetoryl

↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of trilostane in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), which was accessed on September 24, 2018, is reproduced from a self-classification by the distributor .