Volker Haucke

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Volker Haucke (2013)

Volker Haucke (born June 29, 1968 in Bad Berleburg ) is a German biochemist and cell biologist . He is Director at the Leibniz Research Institute for Molecular Pharmacology Berlin (FMP) and Professor for Molecular Pharmacology at the Institute for Pharmacy at the Free University of Berlin .

Live and act

From 1989 to 1994 Volker Haucke studied biochemistry at the Free University of Berlin and at the Biozentrum of the University of Basel as a scholarship holder of the German National Academic Foundation . In 1997 he received his PhD in biochemistry from the University of Basel (Biozentrum) with the grade Summa cum laude for his work in the laboratory of Gottfried Schatz on the mitochondrial protein import machinery. After a research stay funded by the Human Frontier Science Program Organization (HFSP) and the European Molecular Biology Organization ( EMBO) from 1997 to 2000 at the Yale University School of Medicine as a Postdoctoral Research Associate at the Howard Hughes Medical Institute (HHMI) in Pietro De's group Camilli , he headed an independent working group funded by the German Research Foundation at the Center for Biochemistry and Molecular Cell Biology at the University of Göttingen from 2000 . In 2003 he followed a call to the Free University of Berlin as professor of membrane biochemistry. Since 2007 he has also been a member of the NeuroCure Cluster of Excellence at Charité University Medicine Berlin. Haucke was spokesman for the Collaborative Research Centers (SFB) 449 (structure and function of membrane-based receptors, from 2008 to 2010) and 958 (scaffolding of membranes) (2011–2012, deputy spokesman since 2012). Since 2012 Haucke has been Director at the Leibniz Research Institute for Molecular Pharmacology (FMP) in Berlin and Professor (W3-S) for Molecular Pharmacology at the Free University of Berlin. At the FMP he heads the Department of Molecular Pharmacology and Cell Biology. From 2008 to 2016 he was an elected member of the Biochemistry Review Board of the German Research Foundation and from 2007 to 2012 a member of the Editorial Board of the Journal of Biological Chemistry. He is currently a member of the editorial boards of EMBO Reports and Biology of the Cell, the Scientific Advisory Board of the Open Access Platform Matters, and a member of the Faculty of 1000. Haucke has been an elected member of the European Molecular Biology Organization (EMBO) since 2014 and a member of the National Academy of Sciences Leopoldina. Also in 2017 he received the Avanti Award from the American Society for Biochemistry and Molecular Biology (ASBMB) and a grant from the Reinhart Koselleck Program of the German Research Foundation.

Volker Haucke is married and has two daughters.

Research priorities

Volker Haucke and his working group are researching endocytosis and exocytosis , the absorption of substances into and release from cells via membrane-covered vesicles , especially in nerve cells . Another focus of his research is the decoding of the mechanisms of intracellular membrane flow and membrane identity in the endosomal and lysosomal system and their control by special membrane lipids , so-called phosphoinositides . Special attention is paid to the development of tools that influence these processes in a targeted manner, and the development of high-resolution light microscopy methods with which these processes in the cell can be observed directly. His discoveries include discoveries in the field of deciphering mechanisms that control the recycling of synaptic vesicles containing messenger substances in nerve cells and in the brain, and the development of the first selective inhibitors of cellular uptake processes. Volker Haucke and his group were also able to identify signal lipids and the enzymes that convert them, which are of central importance for cellular transport processes and the question of membrane identity and thus the function of intracellular compartments. If these enzymes are missing or their activity or function is impaired, serious diseases can result, ranging from hereditary muscle disorders to cancer to neurological and neurodegenerative diseases.

Scientific memberships

  • Member (Principal Investigator), Cluster of Excellence EXC 257 NeuroCure
  • Founding spokesman and member, SFB 958 Scaffolding of Membranes
  • Member of SFB 740 Functional Protein Modules
  • Member, Helmholtz International Research School Molecular Neurobiology at the Max Delbrück Center Berlin (MDC)
  • Member, TransCard Research School at the MDC
  • Member, American Society for Cell Biology, Bethesda, USA (ASCB)
  • Member, American Society for Biochemistry & Molecular Biology (ASBMB)
  • Member, Society for Neuroscience, Washington DC (SFN)
  • Member, Federation of European Biochemical Societies (FEBS)
  • Member, German Society for Biochemistry & Molecular Biology, Frankfurt, (GBM)
  • Member, German Society for Cell Biology (DGZ), Heidelberg

Honourings and prices

Web links

Video

Individual evidence

  1. ↑ Oliver Daumke, Aurélien Roux, Volker Haucke: BAR Domain Scaffolds in Dynamin-Mediated Membrane Fission . In: Cell . tape 156 , no. 5 , February 27, 2014, p. 882-892 , doi : 10.1016 / j.cell.2014.02.017 .
  2. ↑ Katja Faelber, York Posor, Song Gao, Martin Held, Yvette Roske, Dennis Schulze, Volker Haucke, Frank Noé, Oliver Daumke: Crystal structure of nucleotide-free dynamin . In: Nature . tape 477 , no. 7366 , September 29, 2011, p. 556-560 , doi : 10.1038 / nature10369 .
  3. ↑ Volker Haucke, Erwin Neher, Stephan J. Sigrist: Protein scaffolds in the coupling of synaptic exocytosis and endocytosis . In: Nature Reviews Neuroscience . tape 12 , no. 3 , March 2011, p. 127-138 , doi : 10.1038 / nrn2948 .
  4. ↑ Volker Haucke, Pietro De Camilli: AP-2 Recruitment to Synaptotagmin Stimulated by Tyrosine-Based Endocytic Motifs . In: Science . tape 285 , no. 5431 , August 20, 1999, p. 1268-1271 , doi : 10.1126 / science.285.5431.1268 , PMID 10455054 .
  5. ↑ Natalia L. Kononenko et al .: Clathrin / AP-2 mediate synaptic vesicle reformation from endosome-like vacuoles but are not essential for membrane retrieval at central synapses . In: Neuron . tape 82 , no. 5 , June 4, 2014, p. 981–988 , doi : 10.1016 / j.neuron.2014.05.007 , PMID 24908483 .
  6. ↑ Soykan, T., Kaempf, N., Sakaba, T., Vollweiter, D., Goerdeler, F., Puchkov, D., Kononenko, NL, Haucke, V .: Synaptic vesicle endocytosis occurs on multiple timescales and is mediated by formin-dependent actin assembly . In: Neuron . tape 93 , no. 4 , February 22, 2017, p. 854–866 , doi : 10.1016 / j.neuron.2017.02.011 .
  7. ↑ Lisa von Kleist et al: Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition . In: Cell . tape 146 , no. 3 , August 5, 2011, p. 471-484 , doi : 10.1016 / j.cell.2011.06.025 .
  8. ↑ Posor, York et al.: Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. In: Nature . tape 499 , no. 7457 , July 11, 2013, p. 233-237 , doi : 10.1038 / nature12360 .
  9. ↑ Ketel, K., Krauss, M., Nicot, AS, Puchkov, D., Wieffer, M., Müller, R., Subramanian, D., Schultz, C., Laporte, J., Haucke, V .: A phosphoinositide conversion mechanism for exit from endosomes. In: Nature . tape 529 , no. 7586 , January 21, 2016, p. 408-412 , doi : 10.1038 / nature16516 .
  10. ↑ Andrea L. Marat, Alexander Wallroth, Wen-Ting Lo, Rainer Müller, G. Danilo Norata, Marco Falsaca, Carsten Schultz, Volker Haucke: mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate. In: Science . tape 356 , no. 6341 , June 2, 2017, p. 968-972 , doi : 10.1126 / science.aaf8310 .
  11. ^ Gisela Lerch: Three new members elected to the Berlin-Brandenburg Academy of Sciences. Berlin-Brandenburg Academy of Sciences and Humanities, press release from December 1, 2017 from Informationsdienst Wissenschaft (idw-online.de), accessed on December 1, 2017.
  12. ↑ Member entry by Prof. Dr. Volker Haucke at the German Academy of Sciences Leopoldina , accessed on June 9, 2017.
personal data
SURNAME Haucke, Volker
BRIEF DESCRIPTION German biochemist and cell biologist
DATE OF BIRTH June 29, 1968
PLACE OF BIRTH Bad Berleburg