William C. Stadium

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William Christopher Stadie ( June 15, 1886 - September 12, 1959 ) was an American medic.

Stadie was withdrawn from school for a year on suspicion of tuberculosis (probably unfounded). He graduated from New York University with a bachelor's degree in 1907 and received his doctorate in medicine (MD) from Columbia University in 1916 . He financed his studies by typing the pathology textbook by William George McCallum . During World War I he was in the Army Medical Corps and then completed his internship at the Presbyterian Hospital in New York City before moving to the Rockefeller Institution, where he was originally supposed to study newer methods of syphilis treatment. During the great flu pandemic of 1918 , he developed oxygen therapy to treat the cyanosis that accompanied pneumonia . He also introduced arterial puncture (which at that time was still considered life-threatening) into clinical practice (but he himself assigned the priority to the German physician J. Hurter [1912/14]). From 1921 to 1924 he was on the faculty at Yale University . From 1924 he was Associate Professor at the University of Pennsylvania and from 1941 John Herr Musser Professor of Medical Research.

He researched the toxicity of oxygen and diabetes . Stadie discovered in 1932 with Helen O'Brien in the investigation of the enzymes responsible for binding oxygen and carbon dioxide in the blood, carbonic anhydrase , independently of the British Norman Urquhart Meldrum (1907-1933) and Francis John Worsley Roughton (1899-1972), Er studied the function of this enzyme (mastering modern techniques of enzyme chemistry and use of radioactive isotopes) and improved various methods of blood analysis and the analysis of blood gases. He was the first to be able to attach radioactive tracers to insulin and showed that its high affinity for specific tissues was crucial for its function. He showed that the liver breaks down fats into acetoacetic acid and hydroxybutanoic acid and passes them on to the body for combustion, that the two substances are excreted in diabetics because they are produced by the body faster than they can be burned in the body and that the muscles of diabetics have acetoacetic acid burn at normal rate.

Stadie received the Phillips Medal from the American College of Physicians in 1941 , the Banting Medal from the American Diabetes Association in 1956, and the Kober Medal from the Association of American Physicians in 1955 . Stadie was a member of the National Academy of Sciences (1945). In 1959 he received an honorary doctorate from the University of Pennsylvania.

literature

  • Isaac Starr: William Christopher Stadie, Biographical Memoirs National Academy, Volume 58, 1989, online

Web links

Individual evidence

  1. ↑ Stadie, O'Brien, The catalysis of the hydration of carbon dioxide and dehydration of carbonic acid by an enzyme isolated from the red blood cells, J. Biolog. Chem., Vol. 103, 1933, p. 521
  2. ↑ Lowe, Das Chemiebuch, Librero 2017, p. 288
personal data
SURNAME Stadie, William C.
ALTERNATIVE NAMES Stadie, William Christopher (full name)
BRIEF DESCRIPTION American medic
DATE OF BIRTH June 15, 1886
DATE OF DEATH September 12, 1959