Wolfgang Lindner (chemist)

Wolfgang Lindner (2013)

Wolfgang Lindner (born October 3, 1943 in Mittenwald , Bavaria ) is an Austrian chemist . Since 2012 he has been professor emeritus for analytical chemistry at the University of Vienna .

Life

Wolfgang Lindner studied chemistry between 1962 and 1972 at the University of Vienna and the Karl-Franzens University in Graz . In 1972 he received his doctorate from the University of Graz , where his field of work was organic chemistry . The topic of his dissertation was the gas chromatographic analysis of components of tobacco smoke. Since 1972 Lindner has worked as an assistant professor in the field of pharmaceutical chemistry at the University of Graz and was appointed professor there in 1982. During this time there were various visits to industrial and academic laboratories. From 1973 to 1975, Lindner worked in the group of RW Frei ( Sandoz AG , Basel) and carried out research as a postdoc at Northeastern University with Barry Karger in Boston (USA) in 1978/1979 , before studying pharmaceutical chemistry in January 1982 qualified as a professor at the University of Graz . 1986/1987 Lindner was a visiting scientist at the Food and Drug Administration (FDA) in Bethesda , Maryland (USA).

From 1996 to 2012 Lindner worked as professor and successor to JFK Huber at the University of Vienna.

Research areas

His research focuses on (enantioselective) separation techniques and the materials required for them, such as B.

• new stationary phases for efficient and highly selective chromatography ,
• Molecular recognition (design and synthesis of chiral compounds that are suitable as enantioselective selectors, ligands, synthetic building blocks or for the production of chiral drugs and chiral polymers),
• Investigations for a better understanding of molecular recognition ( QSAR , spectroscopy),
• Studies on stereoselectivity in pharmacokinetics ,
• Affinity chromatography and its application, e.g. B. for protein separation,
• Mycotoxin analysis,
• Environmental analysis as well as food and pesticide analysis ,
• Pharma analysis (drugs, pharmaceuticals, etc.).

Lindner has particular expertise in enantiomer analysis in the broadest sense.

Publications and patents

Wolfgang Lindner's research has resulted in around 450 publications in specialist journals, 12 book chapters and 15 patents. The Hirsch Index of 49 is an indicator of its significant scientific influence.

Publications (selection)

• M. Lämmerhofer, W. Lindner: Quinine and Quinidine Derivatives as Chiral Selectors Ι. Brush Type Chiral Statinary Phases for HPLC Based on Cinchonan Carbamates and Their Application as Chiral Anion Exchangers , J. Chromatogr. A 741, 33-48 (1996).
• A. Leitner, P. Zöllner, W. Lindner: Determination of the Metabolites of Nitrofuran Antibiotics in Animal Tissue by High-Performance Liquid Chromatography-Tandem Mass Spectrometry , J. Chromatogr. A, 939, 49-58 (2001).
• C. Czerwenka, Mei Mei Zhan, HP Kählig, NM Maier, KB Lipkowitz, W. Lindner: Chiral Recognition of Peptide Enantiomers by Cinchona Alkaloid Derived Chiral Selectors: Mechanistic Investigations by Liquid Chromatography, NMR Spectroscopy and Molecular Modeling , J. Org. Chem . 68, 8315-8327 (2003).
• R. Wirz, T. Bürgi, W. Lindner, A. Baiker : Absolute Configuration Modulation ATR-IR Spectroscopy: A new in-situ Method for Probing Chiral Recognition in Liquid Chromatography , Anal. Chem. , 76 (18): 5319-5330 (2004).
• Kevin A. Schug, W. Lindner: Noncovalent Binding between Guanidinium and Anionic Groups: Focus on Biological- and Synthetic-Based Arginine / Guanidinium Interactions with Phosph [on] ate and Sulf [on] ate Residues , Chem. Rev. 105, 67 -113 (2005).
• Kevin Schug, Petr Fryčák, Norbert M. Maier, Wolfgang Lindner: Measurement of Solution Phase Chiral Molecular Recognition in the Gas Phase Using Electrospray Ionization-Mass Spectrometry , Anal. Chem. 77: 3660-3670 (2005).
• Alexander Leitner, Wolfgang Lindner: Functional Probing of Arginine Residues in Proteins using Mass Spectrometry and an Arginine-specific Covalen Tagging Concept , Anal. Chem. 77: 4481-4488 (2005).
• Norbert M. Maier, Wolfgang Lindner: Chiral Recognition Applications of Molecularly Imprinted Polymers: A Critical Review , Anal. Bioanal. Chem. 389 (2), 377-397 (2007).
• Christian Hoffmann, Reinhard Pell, Michael Lämmerhofer, Wolfgang Lindner: Synergistic Effects on Enantioselectivity of Novel Zwitterionic Chiral Stationary Phases for Separations of Chiral Acids, Bases, and Amino Acids by HPLC , Anal. Chem. 80, 8780-8789 (2008).
• Alexander Leitner, Martin Sturm, Otto Hudecz, Michael Mazanek, Jan-Henrik Smátt, Mika Lindén, Wolfgang Lindner, Karl Mechtler: Probing the Phosphoproteome of HeLa Cells Using Nanocast Metal Oxide Microspheres for Phosphopeptide Enrichment , Anal. Chem. 82: 2726-2733 (2010).
• Pavel A. Levkin, Norbert M. Maier, Volker Schurig, Wolfgang Lindner: Strong Detrimental Effect of a Minute Enantiomeric Impurity of a Chiral Selector on the Enantioselectivity Factor , Angewandte Chemie Int. Ed. 49, 7742-7744 (2010), doi : 10.1002 / anie.201002215 .
• Marek Mahut, Andrea Gargano, H. Schuchnigg Wolfgang Lindner, Michael Lämmerhofer: Chemoaffinity Material for Plasmid DNA Analysis by HPLC with Condition-dependent Switching Between Isoform and Topoisomer Selectivity , Anal.Chem. 85, 2913-2020 (2013).
• Stefanie Wernisch, Oliver Trapp, Wolfgang Lindner: Application of Cinchona-sulfonate-based Chiral Zwitterionic Ion Exchangers for the Separation of Proline-containing Dipeptide Rotamers and Determination of On-column Isomerization Parameters from Dynamic Elution Profiles , Anal.Chim Acta 795, 88– 98 (2013).

Activities as editor and member of editorial boards

Lindner is or was editor of several internationally renowned journals ( Chirality , Chromatographia , Journal of Pharmaceutical and Biomedical Analysis , LC GC International , Journal of Chromatography B , J. Biochromatogr. , J. Analytical and Bioanalytical Chemistry and Current Analytical Chemistry ).

Awards

• Jubilee Medal of the British Chromatographic Society (1991)
• Austrian Award for Cardiology (together with K. Stoschitzky and W. Klein) (1992)
• Tswett Memorial Medal (1995)
• 1st Winner of the Belgian Pharmaceutical Society Award (1995)
• Hoechst Prize for Original Science in Medicinal Chemistry (together with K. Stoschitzky and W. Klein) (1996)
• Japan Society for the Promotion of Science (JSPS) (2001)
• Honorary Membership of the Hungarian Society for Separation Sciences (2003)
• Halász Medal Award of the Hungarian Society for Separation Sciences (2007)
• Chirality Medal Award (2008)
• AJP Martin Gold Medal (2009)
• Molecular Chirality Award of Japan (2010)
• ACS Award in Chromatography (2012)
• CASSS Award 2013 for Outstanding Achievements in Separation Sciences (2013)
• Rudolf Zahradník Series Lecture, Palacký University Olomouc (2014)
• Austrian Congress Award (2014)
• Nernst-Tswett Award of EuSSS (2014)

literature

Kevin A. Schug / Interview with Wolfgang Lindner.

Individual evidence

1. ^ Norbert M. Maier: 65th birthday of Professor Wolfgang Lindner, Chromatographia 2008, doi : 10.1365 / s10337-008-0855-4 .
2. ↑ Michael Lämmerhofer: Chiral separations and enantioselectivity, Journal of Chromatography A 1269, 1–3 (2012), doi : 10.1016 / j.chroma.2012.10.009 .
3. ↑ LC GC Europe September 2014, pp. 1–5.