Wolfgang Steglich (chemist)

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Wolfgang Steglich (1998)

Wolfgang Steglich (born August 12, 1933 in Kamenz ) is a German chemist .

Career

Steglich began studying chemistry at the TU Berlin in 1951 , which he completed in 1958 with the main diploma examination. In the same year he moved to the Technical University of Munich , where he in 1960 on the subject peptide synthesis with activated esters of Carbobenzoxyaminosäuren in glacial acetic acid and Entcarbobenzoxylierung with trifluoroacetic acid at Friedrich Weygand doctorate was. This was followed by a one-year research stay at Imperial College London with Sir Derek HR Barton , where Steglich worked on the biosynthesis of opium alkaloids . In 1965 he completed his habilitation at the Technical University of Munich on the subject of studies on pseudooxazolone- (5) and oxazolone- (5) . From 1969 to 1971 Steglich was acting head of Friedrich Weygand's chair before he was appointed full professor of organic chemistry at the TU Berlin. He stayed there until 1975 and then accepted an appointment at the University of Bonn , where he succeeded Rudolf Tschesche as full professor and director at the Institute for Organic Chemistry and Biochemistry. In April 1991, Steglich moved to the Ludwig Maximilians University in Munich , where he succeeded Rolf Huisgen as full professor and head of the Institute for Organic Chemistry. Since October 2001 he has been emeritus at the Institute for Organic Chemistry at the University of Munich.

Steglich has been co-editor of the Zeitschrift für Naturforschung since 1973 and was co-editor of the Chemical Reports from 1975 to 1980 and Honorary Regional Editor of Tetrahedron and Tetrahedron Letters from 1980 to 2001 . From 1979 to 1984 he was a member of the Senate Committee for Collaborative Research Centers of the German Research Foundation .

plant

The bitter pine cone ( Strobilurus tenacellus ) contains strobilurin A and B.

Wolfgang Steglich is the author of more than 500 scientific publications in international journals. The focus of Steglich's work is in the field of natural substances. He deals with the isolation, structure elucidation, synthesis and biosynthesis of biologically active substances and dyes from fungi and slime molds. In collaboration with the biochemist Timm Anke, he succeeded in determining the structure and synthesis of the antifungal strobilurins , which served as lead structures for the development of a new class of environmentally friendly fungicides. In addition, biomimetic syntheses of marine alkaloids and the development of new methods for the modification of amino acids and peptides belong to Steglich's field of work.

In 1978 Steglich described a variant of esterification in which he used the coupling reagent dicyclohexylcarbodiimide (DCC) together with the catalyst 4- (dimethylamino) pyridine (DMAP). This reaction procedure is known today as Steglich esterification .

Important publications (selection)

  • Bernhard Neises, Wolfgang Steglich: Simple method for the esterification of carboxylic acids. In: Angew. Chem. 1978 , 90 , 556-557, doi: 10.1002 / anie.19780900718 ; Angew. Chem. Int. Ed. Engl. 1978 , 17 , 522, doi: 10.1002 / anie.197805221 .
  • Gerhard Höfle, Wolfgang Steglich, Helmut Vorbrüggen: 4-Dialkylaminopyridines as highly active acylation catalysts . In: Angew. Chem. 1978 , 90 , 602-615, doi: 10.1002 / anie.19780900806 ; Angew. Chem. Int. Ed. Engl. 1978 , 17 , 569-583, doi: 10.1002 / anie.197805691 .
  • Markus R. Heinrich, Heike S. Klisa, Herbert Mayr, Wolfgang Steglich, Hendrik Zipse: Enhancing the catalytic activity of 4- (dialkylamino) pyridines by conformational fixation . In: Angew. Chem. 2003 , 115 , 4975-4977, doi: 10.1002 / anie.200352289 ; Angew. Chem. Int. Ed. Engl. 2003 , 42 , 4826-4828, doi: 10.1002 / anie.200352289 .
  • Melvyn Gill, Wolfgang Steglich: Pigments of fungi ( Macromycetes ) . In: Progr. Chem. Org. Nat. Prod. 1987 , 51 , 1─317, doi: 10.1007 / 978-3-7091-6971-1 , ISBN 978-3-7091-6971-1 .
  • Olov Sterner, Bert Steffan, Wolfgang Steglich: Novel azepine derivatives from the pungent mushroom Chalciporus piperatus. In: Tetrahedron 1987 , 43 , 1075-1082, doi: 10.1016 / S0040-4020 (01) 90044-4 .
  • Wolfgang Steglich: Slime molds ( Myxomycetes ) as a source of new biologically active metabolites. In: Pure Appl. Chem. 1989 , 61 , 281-288, doi: 10.1351 / pac198961030281 .
  • Dieter C. Aumann, Gabriele Clooth, Bert Steffan, Wolfgang Steglich: Complexation of cesium 137 by the cap pigments of the bay boletus ( Xerocomus badius ) . In: Angew. Chem. 1989 , 101 , 495─496, doi: 10.1002 / anie.19891010429 ; Angew. Chem. Int. Ed. Engl. 1989 , 28 , 453─454, doi: 10.1002 / anie.198904531 .
  • Wolfgang Steglich, Martin Jäger, Stefan Jaroch, Peter Zistler: Application of α-chloroglycine residues for the modification of oligopeptides . In: Pure Appl. Chem. 1994 , 66 , 2167-2170, doi: 10.1351 / pac199466102167 .
  • Alexander Heim, Andreas Terpin, Wolfgang Steglich: Alkaloids from marine organisms. 2. Biomimetic synthesis of lamellarin G trimethyl ether . In: Angew. Chem. 1997 , 109 , 158-159, doi: 10.1002 / anie.19971090152 ; Angew. Chem. Int. Ed. Engl. 1997 , 36 , 155─156, doi: 10.1002 / anie.199701551 .
  • Hubert Sauter, Wolfgang Steglich, Timm Anke: Strobilurins: Evolution of a new class of active substances . In: Angew. Chem. 1999 , 111 , 1416-1438 ( doi ); Angew. Chem. Int. Ed. Engl. 1999 , 38 , 1328-1349 ( doi ).

Honors (selection)

Honor taxa

  • Galerina steglichii Besl
  • Daldinia steglichii M. Stadler, Baumgartner & Wollw.

literature

  • Klaus Roth: Chemist-style mushroom ragout - Maître Steglich and his kitchen brigade cook . In: Chem. UZ 2015 , 49 , 196, doi: 10.1002 / ciuz.201500712 .
  • Jeffrey I. Seeman: Chapter Another Chemistry Letter to a Young Student . In: RB Woodward's Letters: Revealing, Elegant and Commanding , Helv. Chim. Acta 2017 , 100 , e1700183, doi: 10.1002 / hlca.201700183 .

Web links

Individual evidence

  1. ↑ CV of Prof. Dr. Wolfgang Steglich, University of Munich website ( Memento from November 22, 2010 in the Internet Archive )
  2. ↑ (a) Prof. Dr. Wolfgang Steglich, em., Website University of Munich ( Memento from September 8, 2019 in the Internet Archive ); (b) Working group Prof. Dr. em. Wolfgang Steglich, University of Munich website ( Memento from September 8, 2019 in the Internet Archive ); (c) Overview of research topics Prof. Dr. Wolfgang Steglich, University of Munich website ( Memento from September 8, 2019 in the Internet Archive ); (d) Research topic structure elucidation, website University of Munich ( Memento from September 8, 2019 in the Internet Archive ); (e) Research topic Natural Product Synthesis, University of Munich website ( Memento from September 8, 2019 in the Internet Archive ); (f) Research topic Biosynthesis, University of Munich website ( Memento from September 8, 2019 in the Internet Archive ); (g) Former employees, University of Munich website ( Memento from September 8, 2019 in the Internet Archive ).
  3. ↑ Bernd Schäfer: Natural substances in the chemical industry , spectrum Akademischer Verlag, 2007, pp. 479-480, ISBN 978-3-8274-1614-8 .
  4. ↑ Bavarian Academy of Sciences, member page Prof. Dr. W. Steglich ; Archived page ( Memento from September 8, 2019 in the Internet Archive )
  5. ↑ Gerhard Höfle, Wolfgang Steglich, Helmut Vorbrüggen: 4-Dialkylaminopyridines as Highly Active Acylation Catalysts. In: Angew. Chem. 1978 , 90 , 602-615, doi: 10.1002 / anie.19780900806 ; Angew. Chem. Int. Ed. 1978 , 17 , 569-583, doi: 10.1002 / anie.197805691 .
  6. ↑ Member entry by Prof. Dr. Wolfgang Steglich (with picture) at the German Academy of Sciences Leopoldina , accessed on July 22, 2016. Archived page ( memento from September 8, 2019 in the Internet Archive ).
  7. ↑ Helmut Besl: Galerina steglichii spec. nov., a hallucinogenic Häubling , Z. Mykol. 1993 , 59 (2) , 215-218.
  8. ↑ Marc Stadler, Manuela Baumgartner, Hartmund Wollweber: Three new Daldinia species with yellowish stromatal pigments , Mycotaxon 2001 , 80 , 179–196.
personal data
SURNAME Steglich, Wolfgang
BRIEF DESCRIPTION German chemist and university professor
DATE OF BIRTH August 12, 1933
PLACE OF BIRTH Kamenz