Zinc protoporphyrin
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| General | |||||||||||||||||||
| Surname | Zinc protoporphyrin | ||||||||||||||||||
| other names |
Zinc 3- [7,12-bis (ethenyl) -3,8,13,17-tetramethyl-18- (3-oxido-3-oxopropyl) porphyrin-21,24-diid-2-yl] propanoate |
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| Molecular formula | C 34 H 32 N 4 O 4 Zn | ||||||||||||||||||
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| properties | |||||||||||||||||||
| Molar mass | 624.03 g mol −1 | ||||||||||||||||||
| Physical state |
firmly |
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | |||||||||||||||||||
Zinc protoporphyrin (ZPP) is a chemical from the group of porphyrins . If it is formed instead of a divalent iron - ion (Fe 2+ ) a divalent zinc ion (Zn 2+ ) is incorporated in protoporphyrin IX. This is particularly the case with iron deficiency anemia and lead poisoning . Lead inhibits the enzyme ferrochelatase , which catalyzes the incorporation of iron into the heme framework. As a result, there is an increased incorporation of zinc instead of iron. An increase is also found in the genetic disease erythropoietic protoporphyria (EPP), especially in its X-linked form, in which massive accumulations can occur.
Zinc protoporphyrin is highly fluorescent and can therefore be quantified using fluorescence optics.
literature
- Lothar Thomas: Laboratory and Diagnosis. TH Books Frankfurt / Main (6th edition), ISBN 3-9805215-5-9
Web links
- Zinc protoporphyrin (in EDTA blood) , labor-lademannbogen.de, accessed on January 31, 2017
Individual evidence
- ↑ Data sheet Protoporphyrin IX zinc (II) from Sigma-Aldrich , accessed on January 28, 2013 ( PDF ).
- ↑ Sharon D. Whatley, Sarah Ducamp, et al .: C-Terminal Deletions in the ALAS2 Gene Lead to Gain of Function and Cause X-linked Dominant Protoporphyria without Anemia or Iron Overload. In: The American Journal of Human Genetics . Volume 83, number 3, 2008, pp. 408-414, doi : 10.1016 / j.ajhg.2008.08.003 . ( free full text )