Vesicular glutamate transporter 1: Difference between revisions

SLC17A7
Identifiers
Aliases	SLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDs	OMIM: 605208 MGI: 1920211 HomoloGene: 113454 GeneCards: SLC17A7
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,442,360 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,825,566 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; Brodmann area 10; ; frontal pole; ; Region I of hippocampus proper; ; middle temporal gyrus; ; Brodmann area 46; ; dorsolateral prefrontal cortex; ; orbitofrontal cortex; ; cingulate gyrus; ; postcentral gyrus;
	Top expressed in
	superior frontal gyrus; ; prefrontal cortex; ; piriform cortex; ; cerebellar cortex; ; hippocampus proper; ; primary motor cortex; ; subiculum; ; habenula; ; cerebellar vermis; ; amygdala;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	inorganic phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity; extracellularly glutamate-gated chloride channel activity; symporter activity; L-glutamate transmembrane transporter activity; neurotransmitter transmembrane transporter activity;
Cellular component	postsynapse; integral component of membrane; membrane; synaptic vesicle; plasma membrane; synapse; excitatory synapse; synaptic vesicle membrane; cerebellar mossy fiber; presynaptic active zone; cell junction; intracellular organelle; neuron projection; clathrin-sculpted glutamate transport vesicle membrane; cytoplasmic vesicle; integral component of synaptic vesicle membrane;
Biological process	phosphate ion transport; synaptic transmission, glutamatergic; sodium-dependent phosphate transport; sodium ion transport; chloride transmembrane transport; ion transport; glutamate secretion; synaptic vesicle lumen acidification; brain development; long-term memory; excitatory postsynaptic potential; neurotransmitter transport; neural retina development; L-glutamate import; sequestering of neurotransmitter; sodium ion transmembrane transport; transmembrane transport; chemical synaptic transmission; neurotransmitter loading into synaptic vesicle; L-glutamate transmembrane transport; regulation of synaptic vesicle endocytosis; regulation of synapse structure or activity;
	Sources:Amigo / QuickGO
Orthologs
	57030
	72961
	ENSG00000104888
	ENSMUSG00000070570
	Q9P2U7
	Q3TXX4
	NM_020309
	NM_182993
	NP_064705
	NP_892038
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 03:18, 30 January 2023

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.^[5]^[6]^[7]

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104888 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070570 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143. S2CID 23177236.
^ Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226. S2CID 37857748.
^ ^a ^b "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

Further reading[edit]

Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH (2000). "Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter". Science. 289 (5481): 957–60. Bibcode:2000Sci...289..957B. doi:10.1126/science.289.5481.957. PMID 10938000.
Takamori S, Rhee JS, Rosenmund C, Jahn R (2000). "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons". Nature. 407 (6801): 189–94. Bibcode:2000Natur.407..189T. doi:10.1038/35025070. hdl:11858/00-001M-0000-0012-F987-C. PMID 11001057. S2CID 4412622.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons". Schizophrenia Research. 73 (2–3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259. S2CID 2335413.
Alonso-Nanclares L, De Felipe J (2005). "Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex". Neuroscience. 134 (1): 59–68. doi:10.1016/j.neuroscience.2005.03.038. PMID 15961236. S2CID 25943855.
Vinatier J, Herzog E, Plamont MA, et al. (2006). "Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis". J. Neurochem. 97 (4): 1111–25. doi:10.1111/j.1471-4159.2006.03821.x. PMID 16606361. S2CID 3133505.
Almqvist J, Huang Y, Laaksonen A, et al. (2007). "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters". Protein Sci. 16 (9): 1819–29. doi:10.1110/ps.072944707. PMC 2206968. PMID 17660252.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104888 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070570 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8632143-5] Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143. S2CID 23177236.

[pmid10820226-6] Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226. S2CID 37857748.

[entrez-7] "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
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-| update_page = yes
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+'''Vesicular glutamate transporter 1''' ('''VGLUT1''') is a [[protein]] that in humans is encoded by the ''SLC17A7'' [[gene]].<ref name="pmid8632143">{{cite journal | vauthors = Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM | title = Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter | journal = J Neurochem | volume = 66 | issue = 6 | pages = 2227–38 |date=Jul 1996 | pmid = 8632143 | doi =  10.1046/j.1471-4159.1996.66062227.x| s2cid = 23177236 }}</ref><ref name="pmid10820226">{{cite journal | vauthors = Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J | title = Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter | journal = J Neurochem | volume = 74 | issue = 6 | pages = 2622–5 |date=Jun 2000 | pmid = 10820226 | doi = 10.1046/j.1471-4159.2000.0742622.x | s2cid = 37857748 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57030}}</ref>
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
- | HGNCid = 16704
- | Symbol = SLC17A7
- | AltSymbols =; BNPI; VGLUT1
- | OMIM = 605208
- | ECnumber =
- | Homologene = 69302
- | MGIid =
- | GeneAtlas_image1 = PBB_GE_SLC17A7_204230_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_SLC17A7_204229_at_tn.png
- | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015319 |text = sodium:inorganic phosphate symporter activity}} {{GNF_GO|id=GO:0015321 |text = sodium-dependent phosphate transmembrane transporter activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006817 |text = phosphate transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 57030
-    | Hs_Ensembl = ENSG00000104888
-    | Hs_RefseqProtein = NP_064705
-    | Hs_RefseqmRNA = NM_020309
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 54624470
-    | Hs_GenLoc_end = 54636596
-    | Hs_Uniprot =
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7''', also known as '''SLC17A7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57030| accessdate = }}</ref>
+The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate [[cotransporter]] and they appear to form a distinct class within the Na+/Pi [[cotransporter]] family.<ref name="entrez"/>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.<ref name="entrez">{{cite web | title = Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57030| accessdate = }}</ref>
-}}
 ==See also==
@@ Line 63: / Line 14: @@
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  | vauthors=Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH |title=Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. |journal=Science |volume=289 |issue= 5481 |pages= 957–60 |year= 2000 |pmid= 10938000 |doi=10.1126/science.289.5481.957  |bibcode=2000Sci...289..957B }}
-{{PBB_Further_reading
+*{{cite journal  | vauthors=Takamori S, Rhee JS, Rosenmund C, Jahn R |title=Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. |journal=Nature |volume=407 |issue= 6801 |pages= 189–94 |year= 2000 |pmid= 11001057 |doi= 10.1038/35025070 |bibcode=2000Natur.407..189T |hdl= 11858/00-001M-0000-0012-F987-C |s2cid=4412622 |hdl-access= free }}
-| citations =
-*{{cite journal  | author=Ni B, Du Y, Wu X, ''et al.'' |title=Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter. |journal=J. Neurochem. |volume=66 |issue= 6 |pages= 2227–38 |year= 1996 |pmid= 8632143 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Aihara Y, Mashima H, Onda H, ''et al.'' |title=Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter. |journal=J. Neurochem. |volume=74 |issue= 6 |pages= 2622–5 |year= 2000 |pmid= 10820226 |doi=  }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
-*{{cite journal  | author=Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH |title=Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. |journal=Science |volume=289 |issue= 5481 |pages= 957–60 |year= 2000 |pmid= 10938000 |doi=  }}
+*{{cite journal  | vauthors=Eastwood SL, Harrison PJ |title=Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons. |journal=[[Schizophrenia Research]] |volume=73 |issue= 2–3 |pages= 159–72 |year= 2005 |pmid= 15653259 |doi= 10.1016/j.schres.2004.05.010 |s2cid=2335413 }}
-*{{cite journal  | author=Takamori S, Rhee JS, Rosenmund C, Jahn R |title=Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. |journal=Nature |volume=407 |issue= 6801 |pages= 189–94 |year= 2000 |pmid= 11001057 |doi= 10.1038/35025070 }}
+*{{cite journal  | vauthors=Alonso-Nanclares L, De Felipe J |title=Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex. |journal=Neuroscience |volume=134 |issue= 1 |pages= 59–68 |year= 2005 |pmid= 15961236 |doi= 10.1016/j.neuroscience.2005.03.038 |s2cid=25943855 |url=https://zenodo.org/record/896283 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Vinatier J, Herzog E, Plamont MA, etal |title=Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis. |journal=J. Neurochem. |volume=97 |issue= 4 |pages= 1111–25 |year= 2006 |pmid= 16606361 |doi= 10.1111/j.1471-4159.2006.03821.x |s2cid=3133505 |doi-access=free }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Almqvist J, Huang Y, Laaksonen A, etal |title=Docking and homology modeling explain inhibition of the human vesicular glutamate transporters. |journal=Protein Sci. |volume=16 |issue= 9 |pages= 1819–29 |year= 2007 |pmid= 17660252 |doi= 10.1110/ps.072944707 |pmc=2206968}}
-*{{cite journal  | author=Eastwood SL, Harrison PJ |title=Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons. |journal=[[Schizophrenia Research]] |volume=73 |issue= 2-3 |pages= 159–72 |year= 2005 |pmid= 15653259 |doi= 10.1016/j.schres.2004.05.010 }}
-*{{cite journal  | author=Alonso-Nanclares L, De Felipe J |title=Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex. |journal=Neuroscience |volume=134 |issue= 1 |pages= 59–68 |year= 2005 |pmid= 15961236 |doi= 10.1016/j.neuroscience.2005.03.038 }}
-*{{cite journal  | author=Vinatier J, Herzog E, Plamont MA, ''et al.'' |title=Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis. |journal=J. Neurochem. |volume=97 |issue= 4 |pages= 1111–25 |year= 2006 |pmid= 16606361 |doi= 10.1111/j.1471-4159.2006.03821.x }}
-*{{cite journal  | author=Almqvist J, Huang Y, Laaksonen A, ''et al.'' |title=Docking and homology modeling explain inhibition of the human vesicular glutamate transporters. |journal=Protein Sci. |volume=16 |issue= 9 |pages= 1819–29 |year= 2007 |pmid= 17660252 |doi= 10.1110/ps.072944707 }}
-}}
 {{refend}}
-{{membrane-protein-stub}}
 {{NLM content}}
 {{Membrane transport proteins}}
+{{Glutamate metabolism and transport modulators}}
 [[Category:Solute carrier family]]
+[[Category:Neurotransmitter transporters]]
+[[Category:Glutamate (neurotransmitter)]]
+{{membrane-protein-stub}}

Latest revision as of 03:18, 30 January 2023

See also[edit]

References[edit]

Further reading[edit]