UCP2: Difference between revisions

UCP2
Identifiers
Aliases	UCP2, BMIQ4, SLC25A8, UCPH, uncoupling protein 2
External IDs	OMIM: 601693; MGI: 109354; HomoloGene: 2516; GeneCards: UCP2; OMA:UCP2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	73,983,246 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	100,151,227 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; spleen; ; appendix; ; blood; ; trabecular bone; ; palpebral conjunctiva; ; monocyte; ; lymph node; ; bone marrow cells;
	Top expressed in
	blood; ; epithelium of stomach; ; lip; ; pyloric antrum; ; mucous cell of stomach; ; molar; ; duodenum; ; spleen; ; bone marrow; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; oxidative phosphorylation uncoupler activity; transmembrane transporter activity;
Cellular component	cytoplasm; membrane; mitochondrial membranes; mitochondrial inner membrane; integral component of membrane; mitochondrion;
Biological process	positive regulation of cell death; response to hypoxia; response to superoxide; response to fatty acid; female pregnancy; cellular response to amino acid starvation; negative regulation of insulin secretion involved in cellular response to glucose stimulus; human ageing; negative regulation of apoptotic process; response to glucose; regulation of mitochondrial membrane potential; liver regeneration; cellular response to hormone stimulus; cellular response to insulin stimulus; cellular response to glucose stimulus; response to cold; mitochondrial transmembrane transport; adaptive thermogenesis; mitochondrial transport; proton transmembrane transport; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7351
	22228
	ENSG00000175567
	ENSMUSG00000033685
	P55851
	P70406
	NM_003355
	NM_011671
NP_003346; NP_001368872; NP_001368873; NP_001368874; NP_001368876;
	NP_001368877; NP_001368878; NP_001368879
	NP_035801
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 19:58, 9 June 2008

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Uncoupling protein 2 (mitochondrial, proton carrier), also known as UCP2, is a human gene.

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

Arsenijevic D, Onuma H; et al. (2000). "Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production". Nature Genetics. 26 (Dec): 435–9. doi:10.1038/82565. {{cite journal}}: Explicit use of et al. in: |author= (help)
Bai Y, Onuma H, Bai X; et al. (2005). "Persistent nuclear factor-KB activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production". J Biol Chem. 280 (May 13): 19062–9. doi:10.1074/jbc.M500566200. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Ricquier D, Bouillaud F |title=The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. |journal=Biochem. J. |volume=345 Pt 2 |issue=  |pages= 161-79 |year= 2000 |pmid= 10620491 |doi=  }}
+*{{cite journal  | author=Ricquier D, Bouillaud F |title=The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. |journal=Biochem. J. |volume=345 Pt 2 |issue=  |pages= 161–79 |year= 2000 |pmid= 10620491 |doi=  }}
-*{{cite journal  | author=Saleh MC, Wheeler MB, Chan CB |title=Uncoupling protein-2: evidence for its function as a metabolic regulator. |journal=Diabetologia |volume=45 |issue= 2 |pages= 174-87 |year= 2002 |pmid= 11935148 |doi= 10.1007/s00125-001-0737-x }}
+*{{cite journal  | author=Saleh MC, Wheeler MB, Chan CB |title=Uncoupling protein-2: evidence for its function as a metabolic regulator. |journal=Diabetologia |volume=45 |issue= 2 |pages= 174–87 |year= 2002 |pmid= 11935148 |doi= 10.1007/s00125-001-0737-x }}
-*{{cite journal  | author=Muzzin P |title=The uncoupling proteins. |journal=Ann. Endocrinol. (Paris) |volume=63 |issue= 2 Pt 1 |pages= 106-10 |year= 2002 |pmid= 11994670 |doi=  }}
+*{{cite journal  | author=Muzzin P |title=The uncoupling proteins. |journal=Ann. Endocrinol. (Paris) |volume=63 |issue= 2 Pt 1 |pages= 106–10 |year= 2002 |pmid= 11994670 |doi=  }}
-*{{cite journal  | author=Horvath TL, Diano S, Barnstable C |title=Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. |journal=Biochem. Pharmacol. |volume=65 |issue= 12 |pages= 1917-21 |year= 2003 |pmid= 12787871 |doi=  }}
+*{{cite journal  | author=Horvath TL, Diano S, Barnstable C |title=Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. |journal=Biochem. Pharmacol. |volume=65 |issue= 12 |pages= 1917–21 |year= 2003 |pmid= 12787871 |doi=  }}
-*{{cite journal  | author=Paradis E, Clavel S, Bouillaud F, ''et al.'' |title=Uncoupling protein 2: a novel player in neuroprotection. |journal=Trends in molecular medicine |volume=9 |issue= 12 |pages= 522-5 |year= 2004 |pmid= 14659466 |doi=  }}
+*{{cite journal  | author=Paradis E, Clavel S, Bouillaud F, ''et al.'' |title=Uncoupling protein 2: a novel player in neuroprotection. |journal=Trends in molecular medicine |volume=9 |issue= 12 |pages= 522–5 |year= 2004 |pmid= 14659466 |doi=  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=  }}
-*{{cite journal  | author=Fleury C, Neverova M, Collins S, ''et al.'' |title=Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. |journal=Nat. Genet. |volume=15 |issue= 3 |pages= 269-72 |year= 1997 |pmid= 9054939 |doi= 10.1038/ng0397-269 }}
+*{{cite journal  | author=Fleury C, Neverova M, Collins S, ''et al.'' |title=Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. |journal=Nat. Genet. |volume=15 |issue= 3 |pages= 269–72 |year= 1997 |pmid= 9054939 |doi= 10.1038/ng0397-269 }}
-*{{cite journal  | author=Gimeno RE, Dembski M, Weng X, ''et al.'' |title=Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. |journal=Diabetes |volume=46 |issue= 5 |pages= 900-6 |year= 1997 |pmid= 9133562 |doi=  }}
+*{{cite journal  | author=Gimeno RE, Dembski M, Weng X, ''et al.'' |title=Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. |journal=Diabetes |volume=46 |issue= 5 |pages= 900–6 |year= 1997 |pmid= 9133562 |doi=  }}
-*{{cite journal  | author=Boss O, Samec S, Paoloni-Giacobino A, ''et al.'' |title=Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. |journal=FEBS Lett. |volume=408 |issue= 1 |pages= 39-42 |year= 1997 |pmid= 9180264 |doi=  }}
+*{{cite journal  | author=Boss O, Samec S, Paoloni-Giacobino A, ''et al.'' |title=Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. |journal=FEBS Lett. |volume=408 |issue= 1 |pages= 39–42 |year= 1997 |pmid= 9180264 |doi=  }}
-*{{cite journal  | author=Vidal-Puig A, Solanes G, Grujic D, ''et al.'' |title=UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 79-82 |year= 1997 |pmid= 9196039 |doi= 10.1006/bbrc.1997.6740 }}
+*{{cite journal  | author=Vidal-Puig A, Solanes G, Grujic D, ''et al.'' |title=UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 79–82 |year= 1997 |pmid= 9196039 |doi= 10.1006/bbrc.1997.6740 }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=  }}
-*{{cite journal  | author=Hodný Z, Kolárová P, Rossmeisl M, ''et al.'' |title=High expression of uncoupling protein 2 in foetal liver. |journal=FEBS Lett. |volume=425 |issue= 2 |pages= 185-90 |year= 1998 |pmid= 9559644 |doi=  }}
+*{{cite journal  | author=Hodný Z, Kolárová P, Rossmeisl M, ''et al.'' |title=High expression of uncoupling protein 2 in foetal liver. |journal=FEBS Lett. |volume=425 |issue= 2 |pages= 185–90 |year= 1998 |pmid= 9559644 |doi=  }}
-*{{cite journal  | author=Argyropoulos G, Brown AM, Peterson R, ''et al.'' |title=Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects. |journal=Diabetes |volume=47 |issue= 4 |pages= 685-7 |year= 1998 |pmid= 9568704 |doi=  }}
+*{{cite journal  | author=Argyropoulos G, Brown AM, Peterson R, ''et al.'' |title=Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects. |journal=Diabetes |volume=47 |issue= 4 |pages= 685–7 |year= 1998 |pmid= 9568704 |doi=  }}
-*{{cite journal  | author=Tu N, Chen H, Winnikes U, ''et al.'' |title=Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene. |journal=Life Sci. |volume=64 |issue= 3 |pages= PL41-50 |year= 1999 |pmid= 10027754 |doi=  }}
+*{{cite journal  | author=Tu N, Chen H, Winnikes U, ''et al.'' |title=Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene. |journal=Life Sci. |volume=64 |issue= 3 |pages= PL41–50 |year= 1999 |pmid= 10027754 |doi=  }}
-*{{cite journal  | author=Pecqueur C, Cassard-Doulcier AM, Raimbault S, ''et al.'' |title=Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 1 |pages= 40-6 |year= 1999 |pmid= 10082652 |doi= 10.1006/bbrc.1998.0146 }}
+*{{cite journal  | author=Pecqueur C, Cassard-Doulcier AM, Raimbault S, ''et al.'' |title=Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 1 |pages= 40–6 |year= 1999 |pmid= 10082652 |doi= 10.1006/bbrc.1998.0146 }}
-*{{cite journal  | author=Jezek P, Urbánková E |title=Specific sequence of motifs of mitochondrial uncoupling proteins. |journal=IUBMB Life |volume=49 |issue= 1 |pages= 63-70 |year= 2000 |pmid= 10772343 |doi=  }}
+*{{cite journal  | author=Jezek P, Urbánková E |title=Specific sequence of motifs of mitochondrial uncoupling proteins. |journal=IUBMB Life |volume=49 |issue= 1 |pages= 63–70 |year= 2000 |pmid= 10772343 |doi=  }}
-*{{cite journal  | author=Pierrat B, Ito M, Hinz W, ''et al.'' |title=Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family. |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2680-7 |year= 2000 |pmid= 10785390 |doi=  }}
+*{{cite journal  | author=Pierrat B, Ito M, Hinz W, ''et al.'' |title=Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family. |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2680–7 |year= 2000 |pmid= 10785390 |doi=  }}
-*{{cite journal  | author=Esterbauer H, Schneitler C, Oberkofler H, ''et al.'' |title=A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. |journal=Nat. Genet. |volume=28 |issue= 2 |pages= 178-83 |year= 2001 |pmid= 11381268 |doi= 10.1038/88911 }}
+*{{cite journal  | author=Esterbauer H, Schneitler C, Oberkofler H, ''et al.'' |title=A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. |journal=Nat. Genet. |volume=28 |issue= 2 |pages= 178–83 |year= 2001 |pmid= 11381268 |doi= 10.1038/88911 }}
-*{{cite journal  | author=Echtay KS, Roussel D, St-Pierre J, ''et al.'' |title=Superoxide activates mitochondrial uncoupling proteins. |journal=Nature |volume=415 |issue= 6867 |pages= 96-9 |year= 2002 |pmid= 11780125 |doi= 10.1038/415096a }}
+*{{cite journal  | author=Echtay KS, Roussel D, St-Pierre J, ''et al.'' |title=Superoxide activates mitochondrial uncoupling proteins. |journal=Nature |volume=415 |issue= 6867 |pages= 96–9 |year= 2002 |pmid= 11780125 |doi= 10.1038/415096a }}
 }}
-*{{cite journal  | author=Arsenijevic D, Onuma H, ''et al.'' |title=Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. |journal=Nature Genetics |volume=26 |issue= Dec |pages= 435-9 |year= 2000 }}
+*{{cite journal  | author=Arsenijevic D, Onuma H, ''et al.'' |title=Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. |journal=Nature Genetics |volume=26 |issue= Dec |pages= 435–9 |year= 2000 |doi=10.1038/82565 }}
-*{{cite journal  | author=Bai Y, Onuma H, Bai X, ''et al.'' |title=Persistent nuclear factor-KB activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. |journal=J Biol Chem |volume=280 |issue= May 13 |pages= 19062-9 |year= 2005 }}
+*{{cite journal  | author=Bai Y, Onuma H, Bai X, ''et al.'' |title=Persistent nuclear factor-KB activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. |journal=J Biol Chem |volume=280 |issue= May 13 |pages= 19062–9 |year= 2005 |doi=10.1074/jbc.M500566200 }}
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UCP2: Difference between revisions

Revision as of 19:58, 9 June 2008

See also

References

Further reading