UCP2: Difference between revisions

UCP2
Identifiers
Aliases	UCP2, BMIQ4, SLC25A8, UCPH, uncoupling protein 2
External IDs	OMIM: 601693; MGI: 109354; HomoloGene: 2516; GeneCards: UCP2; OMA:UCP2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	73,983,246 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	100,151,227 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; spleen; ; appendix; ; blood; ; trabecular bone; ; palpebral conjunctiva; ; monocyte; ; lymph node; ; bone marrow cells;
	Top expressed in
	blood; ; epithelium of stomach; ; lip; ; pyloric antrum; ; mucous cell of stomach; ; molar; ; duodenum; ; spleen; ; bone marrow; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; oxidative phosphorylation uncoupler activity; transmembrane transporter activity;
Cellular component	cytoplasm; membrane; mitochondrial membranes; mitochondrial inner membrane; integral component of membrane; mitochondrion;
Biological process	positive regulation of cell death; response to hypoxia; response to superoxide; response to fatty acid; female pregnancy; cellular response to amino acid starvation; negative regulation of insulin secretion involved in cellular response to glucose stimulus; human ageing; negative regulation of apoptotic process; response to glucose; regulation of mitochondrial membrane potential; liver regeneration; cellular response to hormone stimulus; cellular response to insulin stimulus; cellular response to glucose stimulus; response to cold; mitochondrial transmembrane transport; adaptive thermogenesis; mitochondrial transport; proton transmembrane transport; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7351
	22228
	ENSG00000175567
	ENSMUSG00000033685
	P55851
	P70406
	NM_003355
	NM_011671
NP_003346; NP_001368872; NP_001368873; NP_001368874; NP_001368876;
	NP_001368877; NP_001368878; NP_001368879
	NP_035801
	Wikidata
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Revision as of 00:34, 4 June 2016

Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene.^[5]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (Jul 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.

Arsenijevic D, Onuma H, et al. (2000). "Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production". Nature Genetics. 26 (Dec): 435–9. doi:10.1038/82565. PMID 11101840.
Bai Y, Onuma H, Bai X, et al. (2005). "Persistent nuclear factor-KB activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production". J Biol Chem. 280 (May 13): 19062–9. doi:10.1074/jbc.M500566200. PMC 1382174. PMID 15757894.{{cite journal}}: CS1 maint: unflagged free DOI (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9196039-5] Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (Jul 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.

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 {{Infobox_gene}}
-'''Mitochondrial uncoupling protein 2''' is a [[protein]] that in humans is encoded by the ''UCP2'' [[gene]].<ref name="pmid9196039">{{cite journal | author = Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB | title = UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue | journal = Biochem Biophys Res Commun | volume = 235 | issue = 1 | pages = 79–82 |date=Jul 1997 | pmid = 9196039 | pmc =  | doi = 10.1006/bbrc.1997.6740 }}</ref>
+'''Mitochondrial uncoupling protein 2''' is a [[protein]] that in humans is encoded by the ''UCP2'' [[gene]].<ref name="pmid9196039">{{cite journal | vauthors = Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB | title = UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue | journal = Biochem Biophys Res Commun | volume = 235 | issue = 1 | pages = 79–82 |date=Jul 1997 | pmid = 9196039 | pmc =  | doi = 10.1006/bbrc.1997.6740 }}</ref>
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 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Ricquier D, Bouillaud F |title=The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. |journal=Biochem. J. |volume=345 |issue=  2|pages= 161–79 |year= 2000 |pmid= 10620491 |doi=10.1042/0264-6021:3450161  | pmc=1220743  }}
+*{{cite journal  | vauthors=Ricquier D, Bouillaud F |title=The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. |journal=Biochem. J. |volume=345 |issue=  2|pages= 161–79 |year= 2000 |pmid= 10620491 |doi=10.1042/0264-6021:3450161  | pmc=1220743  }}
-*{{cite journal  | author=Saleh MC, Wheeler MB, Chan CB |title=Uncoupling protein-2: evidence for its function as a metabolic regulator. |journal=Diabetologia |volume=45 |issue= 2 |pages= 174–87 |year= 2002 |pmid= 11935148 |doi= 10.1007/s00125-001-0737-x }}
+*{{cite journal  | vauthors=Saleh MC, Wheeler MB, Chan CB |title=Uncoupling protein-2: evidence for its function as a metabolic regulator. |journal=Diabetologia |volume=45 |issue= 2 |pages= 174–87 |year= 2002 |pmid= 11935148 |doi= 10.1007/s00125-001-0737-x }}
 *{{cite journal  | author=Muzzin P |title=The uncoupling proteins. |journal=Ann. Endocrinol. (Paris) |volume=63 |issue= 2 Pt 1 |pages= 106–10 |year= 2002 |pmid= 11994670 |doi=  }}
-*{{cite journal  | author=Horvath TL, Diano S, Barnstable C |title=Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. |journal=Biochem. Pharmacol. |volume=65 |issue= 12 |pages= 1917–21 |year= 2003 |pmid= 12787871 |doi=10.1016/S0006-2952(03)00143-6  }}
+*{{cite journal  | vauthors=Horvath TL, Diano S, Barnstable C |title=Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. |journal=Biochem. Pharmacol. |volume=65 |issue= 12 |pages= 1917–21 |year= 2003 |pmid= 12787871 |doi=10.1016/S0006-2952(03)00143-6  }}
 *{{cite journal   |vauthors=Paradis E, Clavel S, Bouillaud F, etal |title=Uncoupling protein 2: a novel player in neuroprotection. |journal=Trends in molecular medicine |volume=9 |issue= 12 |pages= 522–5 |year= 2004 |pmid= 14659466 |doi=10.1016/j.molmed.2003.10.009  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
+*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
 *{{cite journal   |vauthors=Fleury C, Neverova M, Collins S, etal |title=Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. |journal=Nat. Genet. |volume=15 |issue= 3 |pages= 269–72 |year= 1997 |pmid= 9054939 |doi= 10.1038/ng0397-269 }}
 *{{cite journal   |vauthors=Gimeno RE, Dembski M, Weng X, etal |title=Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. |journal=Diabetes |volume=46 |issue= 5 |pages= 900–6 |year= 1997 |pmid= 9133562 |doi=10.2337/diabetes.46.5.900  }}
@@ Line 33: / Line 34: @@
 *{{cite journal   |vauthors=Tu N, Chen H, Winnikes U, etal |title=Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene. |journal=Life Sci. |volume=64 |issue= 3 |pages= PL41–50 |year= 1999 |pmid= 10027754 |doi=10.1016/S0024-3205(98)00555-4  }}
 *{{cite journal   |vauthors=Pecqueur C, Cassard-Doulcier AM, Raimbault S, etal |title=Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 1 |pages= 40–6 |year= 1999 |pmid= 10082652 |doi= 10.1006/bbrc.1998.0146 }}
-*{{cite journal  | author=Jezek P, Urbánková E |title=Specific sequence of motifs of mitochondrial uncoupling proteins. |journal=IUBMB Life |volume=49 |issue= 1 |pages= 63–70 |year= 2000 |pmid= 10772343 |doi=10.1080/713803586  }}
+*{{cite journal  | vauthors=Jezek P, Urbánková E |title=Specific sequence of motifs of mitochondrial uncoupling proteins. |journal=IUBMB Life |volume=49 |issue= 1 |pages= 63–70 |year= 2000 |pmid= 10772343 |doi=10.1080/713803586  }}
 *{{cite journal   |vauthors=Pierrat B, Ito M, Hinz W, etal |title=Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family. |journal=Eur. J. Biochem. |volume=267 |issue= 9 |pages= 2680–7 |year= 2000 |pmid= 10785390 |doi=10.1046/j.1432-1327.2000.01285.x  }}
 *{{cite journal   |vauthors=Esterbauer H, Schneitler C, Oberkofler H, etal |title=A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. |journal=Nat. Genet. |volume=28 |issue= 2 |pages= 178–83 |year= 2001 |pmid= 11381268 |doi= 10.1038/88911 }}

Revision as of 00:34, 4 June 2016

See also

References

Further reading