UCP2: Difference between revisions

UCP2
Identifiers
Aliases	UCP2, BMIQ4, SLC25A8, UCPH, uncoupling protein 2
External IDs	OMIM: 601693; MGI: 109354; HomoloGene: 2516; GeneCards: UCP2; OMA:UCP2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	73,983,246 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	100,151,227 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; bronchial epithelial cell; ; right uterine tube; ; spleen; ; epithelium of nasopharynx; ; appendix; ; blood; ; trabecular bone; ; nasal epithelium; ; palpebral conjunctiva;
	Top expressed in
	blood; ; epithelium of stomach; ; granulocyte; ; lip; ; pyloric antrum; ; fetal liver hematopoietic progenitor cell; ; mucous cell of stomach; ; tibiofemoral joint; ; molar; ; mesenteric lymph nodes;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; oxidative phosphorylation uncoupler activity; transmembrane transporter activity;
Cellular component	cytoplasm; membrane; mitochondrial membranes; mitochondrial inner membrane; integral component of membrane; mitochondrion;
Biological process	positive regulation of cell death; response to hypoxia; response to superoxide; response to fatty acid; female pregnancy; cellular response to amino acid starvation; negative regulation of insulin secretion involved in cellular response to glucose stimulus; human ageing; negative regulation of apoptotic process; response to glucose; regulation of mitochondrial membrane potential; liver regeneration; cellular response to hormone stimulus; cellular response to insulin stimulus; cellular response to glucose stimulus; response to cold; mitochondrial transmembrane transport; adaptive thermogenesis; mitochondrial transport; proton transmembrane transport; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7351
	22228
	ENSG00000175567
	ENSMUSG00000033685
	P55851
	P70406
	NM_003355
	NM_011671
NP_003346; NP_001368872; NP_001368873; NP_001368874; NP_001368876;
	NP_001368877; NP_001368878; NP_001368879
	NP_035801
	Wikidata
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Revision as of 11:52, 11 October 2018

Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene.^[5]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (Jul 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.

Rupprecht, Anne (2014). "Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function". PLoS One. 9 (2). doi:https://doi.org/10.1371/journal.pone.0088474. {{cite journal}}: Check |doi= value (help); External link in |doi= (help); More than one of author-name-list parameters specified (help)
Bai Y, Onuma H, Bai X, et al. (2005). "Persistent nuclear factor-KB activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production". J Biol Chem. 280 (May 13): 19062–9. doi:10.1074/jbc.M500566200. PMC 1382174. PMID 15757894.{{cite journal}}: CS1 maint: unflagged free DOI (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9196039-5] Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (Jul 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.

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 ==Further reading==
-{{refbegin | 2}}
+{{refbegin|2}}
 {{PBB_Further_reading
 | citations =
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 *{{cite journal   |vauthors=Echtay KS, Roussel D, St-Pierre J, etal |title=Superoxide activates mitochondrial uncoupling proteins. |journal=Nature |volume=415 |issue= 6867 |pages= 96–9 |year= 2002 |pmid= 11780125 |doi= 10.1038/415096a }}
 }}
-*{{cite journal   |vauthors=Arsenijevic D, Onuma H, etal |title=Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. |journal=Nature Genetics |volume=26 |issue= Dec |pages= 435–9 |year= 2000 |doi=10.1038/82565  | pmid=11101840 }}
+*{{cite journal|last=Rupprecht|first=Anne|vauthors=Rupprecht A, Sittner D, Smorodchenko A, Hilse KE, Goyn J, Moldzio R, Seiler AE, Bräuer AU, Pohl EE|title=Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function|url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088474|journal=PLoS One|volume=9|issue=2|pages=|date=|year=2014|doi=https://doi.org/10.1371/journal.pone.0088474|pmid=|via=}}
-*{{cite journal   |vauthors=Bai Y, Onuma H, Bai X, etal |title=Persistent nuclear factor-KB activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. |journal=J Biol Chem |volume=280 |issue= May 13 |pages= 19062–9 |year= 2005 |doi=10.1074/jbc.M500566200  | pmid=15757894  | pmc=1382174 }}
+*{{cite journal|last=|first=|vauthors=Bai Y, Onuma H, Bai X, etal|title=Persistent nuclear factor-KB activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production.|url=|journal=J Biol Chem|volume=280|issue=May 13|pages=19062–9|date=|year=2005|doi=10.1074/jbc.M500566200|pmid=15757894|via=|pmc=1382174}}
 {{refend}}

Revision as of 11:52, 11 October 2018

See also

References

Further reading