UCP2: Difference between revisions

UCP2
Identifiers
Aliases	UCP2, BMIQ4, SLC25A8, UCPH, uncoupling protein 2
External IDs	OMIM: 601693; MGI: 109354; HomoloGene: 2516; GeneCards: UCP2; OMA:UCP2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	73,983,246 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	100,151,227 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; spleen; ; appendix; ; blood; ; trabecular bone; ; palpebral conjunctiva; ; monocyte; ; lymph node; ; bone marrow cells;
	Top expressed in
	blood; ; epithelium of stomach; ; lip; ; pyloric antrum; ; mucous cell of stomach; ; molar; ; duodenum; ; spleen; ; bone marrow; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; oxidative phosphorylation uncoupler activity; transmembrane transporter activity;
Cellular component	cytoplasm; membrane; mitochondrial membranes; mitochondrial inner membrane; integral component of membrane; mitochondrion;
Biological process	positive regulation of cell death; response to hypoxia; response to superoxide; response to fatty acid; female pregnancy; cellular response to amino acid starvation; negative regulation of insulin secretion involved in cellular response to glucose stimulus; human ageing; negative regulation of apoptotic process; response to glucose; regulation of mitochondrial membrane potential; liver regeneration; cellular response to hormone stimulus; cellular response to insulin stimulus; cellular response to glucose stimulus; response to cold; mitochondrial transmembrane transport; adaptive thermogenesis; mitochondrial transport; proton transmembrane transport; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7351
	22228
	ENSG00000175567
	ENSMUSG00000033685
	P55851
	P70406
	NM_003355
	NM_011671
NP_003346; NP_001368872; NP_001368873; NP_001368874; NP_001368876;
	NP_001368877; NP_001368878; NP_001368879
	NP_035801
	Wikidata
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Revision as of 12:09, 11 October 2018

Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene.^[5]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (Jul 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.

Rupprecht A, Bräuer AU, Smorodchenko A, Goyn J, Hilse KE, Shabalina IG, Infante-Duarte C, Pohl EE (2012). "Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation". PLoS One. 7 (8). doi:10.1371/journal.pone.0041406.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Bai Y, Onuma H, Bai X, et al. (2005). "Persistent nuclear factor-KB activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production". J Biol Chem. 280 (May 13): 19062–9. doi:10.1074/jbc.M500566200. PMC 1382174. PMID 15757894.{{cite journal}}: CS1 maint: unflagged free DOI (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175567 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033685 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9196039-5] Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (Jul 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.

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@@ Line 39: / Line 39: @@
 *{{cite journal   |vauthors=Echtay KS, Roussel D, St-Pierre J, etal |title=Superoxide activates mitochondrial uncoupling proteins. |journal=Nature |volume=415 |issue= 6867 |pages= 96–9 |year= 2002 |pmid= 11780125 |doi= 10.1038/415096a }}
 }}
-*{{cite journal|last=|first=|vauthors=Rupprecht, A; Bräuer, AU; Smorodchenko, A; Goyn, J; Hilse, KE; Shabalina, IG; Infante-Duarte, C; Pohl, EE|title=Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation|url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041406|journal=PLoS One|volume=7|issue=8|pages=|date=|year=2012|doi=10.1371/journal.pone.0041406|pmid=|via=}}
+*{{cite journal|last=|first=|vauthors=Rupprecht A, Bräuer AU, Smorodchenko A, Goyn J, Hilse KE, Shabalina IG, Infante-Duarte C, Pohl EE|title=Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation|url=https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041406|journal=PLoS One|volume=7|issue=8|pages=|date=|year=2012|doi=10.1371/journal.pone.0041406|pmid=|via=}}
 *{{cite journal|last=|first=|vauthors=Bai Y, Onuma H, Bai X, etal|title=Persistent nuclear factor-KB activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production.|url=|journal=J Biol Chem|volume=280|issue=May 13|pages=19062–9|date=|year=2005|doi=10.1074/jbc.M500566200|pmid=15757894|via=|pmc=1382174}}

UCP2: Difference between revisions

Revision as of 12:09, 11 October 2018

See also

References

Further reading