Anion exchange protein 2

SLC4A2
Identifiers
Aliases	SLC4A2, AE2, BND3L, EPB3L1, HKB3, NBND3, solute carrier family 4 member 2
External IDs	OMIM: 109280; MGI: 109351; HomoloGene: 128699; GeneCards: SLC4A2; OMA:SLC4A2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	151,076,526 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,645,948 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; canal of the cervix; ; right lobe of liver; ; body of pancreas; ; stromal cell of endometrium; ; left uterine tube; ; retinal pigment epithelium; ; upper lobe of left lung; ; right uterine tube; ; ascending aorta;
	Top expressed in
	epithelium of stomach; ; yolk sac; ; mucous cell of stomach; ; retinal pigment epithelium; ; pyloric antrum; ; molar; ; crypt of lieberkuhn of small intestine; ; lip; ; ileum; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme binding; anion transmembrane transporter activity; antiporter activity; transporter activity; inorganic anion exchanger activity; sodium:bicarbonate symporter activity;
Cellular component	integral component of membrane; plasma membrane; basolateral plasma membrane; apical plasma membrane; membrane; focal adhesion; integral component of plasma membrane;
Biological process	digestive tract development; anion transport; spermatogenesis; ion transport; regulation of intracellular pH; inorganic anion transport; transmembrane transport; anion transmembrane transport; bicarbonate transport; sodium ion transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	6522
	20535
	ENSG00000164889
	ENSMUSG00000028962
	P04920
	P13808
	NM_001199692; NM_001199693; NM_001199694; NM_003040
	NM_001253892; NM_009207
	NP_001186621; NP_001186622; NP_001186623; NP_003031
	NP_001240821; NP_033233
	Wikidata
View/Edit Human	View/Edit Mouse

Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene.^[5]^[6] AE2 is functionally similar to the Band 3 Cl⁻/HCO3⁻ exchange protein.

Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO₃⁻ transport in the gastrointestinal tract.^[7] AE2 is required for spermiogenesis in mice.^[8] AE2 is required for normal osteoclast function.^[9]^[10] The activity of AE2 is sensitive to pH.^[11]

AE3 has been suggested as a target for prevention of diabetic vasculopathy.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164889 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028962 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanner MJ (Mar 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol. 30 (1): 34–57. PMID 8434259.
^ "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)".
^ Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (April 2010). "AE2 Cl⁻/HCO₃⁻ exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. doi:10.1152/ajpgi.00178.2009. PMC 2853300. PMID 20110461.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP (December 2003). "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. doi:10.1073/pnas.2536127100. PMC 307656. PMID 14673081.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Wu J, Glimcher LH, Aliprantis AO (November 2008). "HCO₃⁻/Cl⁻ anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. doi:10.1073/pnas.0808763105. PMC 2579356. PMID 18971331.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O (February 2009). "Targeted disruption of the Cl⁻/HCO₃⁻ exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. doi:10.1073/pnas.0811682106. PMC 2635809. PMID 19164575.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (March 2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
^ Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis. 15 (6): 693–704. doi:10.1007/s10495-010-0477-9. PMID 20180022.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Gehrig H, Müller W, Appelhans H (1992). "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human kidney". Biochim. Biophys. Acta. 1130 (3): 326–8. doi:10.1016/0167-4781(92)90446-7. PMID 1562608.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Korsgren C, Cohen CM (1988). "Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3". J. Biol. Chem. 263 (21): 10212–8. PMID 2968981.
Demuth DR, Showe LC, Ballantine M, et al. (1986). "Cloning and structural characterization of a human non-erythroid band 3-like protein". EMBO J. 5 (6): 1205–14. PMC 1166929. PMID 3015590.
Palumbo AP, Isobe M, Huebner K, et al. (1986). "Chromosomal localization of a human band 3-like gene to region 7q35----7q36". Am. J. Hum. Genet. 39 (3): 307–16. PMC 1683956. PMID 3020980.
Rybicki AC, Musto S, Schwartz RS (1995). "Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2". Biochem. J. 309. ( Pt 2): 677–81. PMC 1135783. PMID 7626035.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Havenga MJ, Bosman GJ, Appelhans H, De Grip WJ (1995). "Expression of the anion exchanger (AE) gene family in human brain. Identification of a new AE protein: AE0". Brain Res. Mol. Brain Res. 25 (1–2): 97–104. doi:10.1016/0169-328X(94)90283-6. PMID 7984058.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Medina JF, Acín A, Prieto J (1997). "Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene". Genomics. 39 (1): 74–85. doi:10.1006/geno.1996.4467. PMID 9027488.{{cite journal}}: CS1 maint: multiple names: authors list (link)
García C, Montuenga LM, Medina JF, Prieto J (1998). "In situ detection of AE2 anion-exchanger mRNA in the human liver". Cell Tissue Res. 291 (3): 481–8. doi:10.1007/s004410051017. PMID 9477304.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Jöns T, Drenckhahn D (1998). "Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells". Eur. J. Cell Biol. 75 (3): 232–6. doi:10.1016/s0171-9335(98)80117-9. PMID 9587054.
Mobasheri A, Golding S, Pagakis SN, et al. (1999). "Expression of cation exchanger NHE and anion exchanger AE isoforms in primary human bone-derived osteoblasts". Cell Biol. Int. 22 (7–8): 551–62. doi:10.1006/cbir.1998.0299. PMID 10452823.
Hyde K, Harrison D, Hollingsworth MA, Harris A (1999). "Chloride-bicarbonate exchangers in the human fetal pancreas". Biochem. Biophys. Res. Commun. 263 (2): 315–21. doi:10.1006/bbrc.1999.1367. PMID 10491290.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Holappa K, Mustonen M, Parvinen M, et al. (1999). "Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis". Biol. Reprod. 61 (4): 981–6. doi:10.1095/biolreprod61.4.981. PMID 10491633.
Karet FE, Finberg KE, Nayir A, et al. (2000). "Localization of a gene for autosomal recessive distal renal tubular acidosis with normal hearing (rdRTA2) to 7q33-34". Am. J. Hum. Genet. 65 (6): 1656–65. doi:10.1086/302679. PMC 1288376. PMID 10577919.
Medina JF, Lecanda J, Acín A, et al. (2000). "Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene". Biochem. Biophys. Res. Commun. 267 (1): 228–35. doi:10.1006/bbrc.1999.1951. PMID 10623603.
Vince JW, Reithmeier RA (2000). "Identification of the Carbonic Anhydrase II Binding Site in the Cl⁻/HCO₃⁻ Anion Exchanger AE1". Biochemistry. 39 (18): 5527–33. doi:10.1021/bi992564p. PMID 10820026.
Holappa K, Suokas M, Soininen P, Kellokumpu S (2001). "Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts". J. Histochem. Cytochem. 49 (2): 259–69. doi:10.1177/002215540104900213. PMID 11156694.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Soleimani M, Greeley T, Petrovic S, et al. (2001). "Pendrin: an apical Cl⁻/OH⁻/HCO³⁻ exchanger in the kidney cortex". Am. J. Physiol. Renal Physiol. 280 (2): F356–64. PMID 11208611.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164889 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028962 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8434259-5] Tanner MJ (Mar 1993). "Molecular and cellular biology of the erythrocyte anion exchanger (AE1)". Semin Hematol. 30 (1): 34–57. PMID 8434259.

[entrez-6] "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)".

[pmid20110461-7] Gawenis LR, Bradford EM, Alper SL, Prasad V, Shull GE (April 2010). "AE2 Cl⁻/HCO₃⁻ exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon". Am. J. Physiol. Gastrointest. Liver Physiol. 298 (4): G493–503. doi:10.1152/ajpgi.00178.2009. PMC 2853300. PMID 20110461.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid14673081-8] Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP (December 2003). "Anion exchanger 2 is essential for spermiogenesis in mice". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15847–52. doi:10.1073/pnas.2536127100. PMC 307656. PMID 14673081.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid18971331-9] Wu J, Glimcher LH, Aliprantis AO (November 2008). "HCO₃⁻/Cl⁻ anion exchanger SLC4A2 is required for proper osteoclast differentiation and function". Proc. Natl. Acad. Sci. U.S.A. 105 (44): 16934–9. doi:10.1073/pnas.0808763105. PMC 2579356. PMID 18971331.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid19164575-10] Josephsen K, Praetorius J, Frische S, Gawenis LR, Kwon TH, Agre P, Nielsen S, Fejerskov O (February 2009). "Targeted disruption of the Cl⁻/HCO₃⁻ exchanger Ae2 results in osteopetrosis in mice". Proc. Natl. Acad. Sci. U.S.A. 106 (5): 1638–41. doi:10.1073/pnas.0811682106. PMC 2635809. PMID 19164575.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid19103596-11] Stewart AK, Kurschat CE, Vaughan-Jones RD, Alper SL (March 2009). "Putative re-entrant loop 1 of AE2 transmembrane domain has a major role in acute regulation of anion exchange by pH". J. Biol. Chem. 284 (10): 6126–39. doi:10.1074/jbc.M802051200. PMC 2649077. PMID 19103596.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

[pmid20180022-12] Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in apoptosis of endothelial cells induced by high glucose through an mPTP-ROS-Caspase-3 dependent pathway". Apoptosis. 15 (6): 693–704. doi:10.1007/s10495-010-0477-9. PMID 20180022.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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Anion exchange protein 2

See also

References

Further reading