Phosphotransferase

Phosphotransferases are a category of enzymes (EC number 2.7) which catalyze phosphorylation reactions. The general form of the reactions they catalyze is:

A—P + B ⇔ B—P + A

Where P is a phosphate group and A and B are the donating and accepting molecules, respectively.

Phosphostransferase system

The phosphotransferase system (PTS) is a complex group translocation system present in many bacteria. The PTS transports sugars (such as glucose, mannose, and mannitol) into the cell. The first step of this reaction is phosphorylation of the substrate via phosphotransferase during transport. In the case of glucose, the product of this phosphorylation is Glucose-6-Phosphate. Due to the negative charge of the Phosphate, this Glu-6P can no longer freely leave the cell. This is the first reaction of Glycolysis (which will degrade the sugar to Pyruvate).

External links

Phosphotransferases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
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