PFKP
Phosphofructokinase, platelet type | ||
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other names |
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Properties of human protein | ||
Mass / length primary structure | 784 amino acids, 85596 Da (isoform 1) |
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Identifier | ||
Gene name | PFKP | |
External IDs | ||
Enzyme classification | ||
EC, category | 2.7.1.11 | |
Orthologue | ||
human | House mouse | |
Entrez | 5214 | 56421 |
Ensemble | ENSG00000067057 | ENSMUSG00000021196 |
UniProt | Q01813 | Q9WUA3 |
Refseq (mRNA) | NM_001242339 | NM_001291071 |
Refseq (protein) | NP_001229268 | NP_001278000 |
Gene locus | Chr 10: 3.07 - 3.14 Mb | Chr 13: 6.58 - 6.65 Mb |
PubMed search | 5214 |
56421
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The phosphofructokinase, platelet type (in German phosphofructokinase type blood platelets , PFKP ) is an enzyme that forms the platelet (P) subunit of the tetrameric enzyme phosphofructokinase 1 and catalyzes the rate-limiting step of glycolysis , namely the conversion of D- fructose-6- phosphate to D- fructose-1,6-bisphosphate . PFKP is the same PFKP - gene that in humans to chromosome 10 is, encoded .
function
The PFKP gene codes for the platelet isoform of phosphofructokinase 1 ( PFK1 ). Phosphofructokinases catalyze the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and are key enzymes for glycolysis. The PFKP gene mapped on chromosome 10p is also expressed in fibroblasts . In platelets expressed tetrameric phosphofructokinase enzymes can consist of the subunits P4 P3L and P2L2.
Individual evidence
- ↑ a b phosphofructokinase, platelet (human)
- ↑ S. Vora: Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system. In: Blood. Volume 57, Number 4, April 1981, pp. 724-732, PMID 6451249 .