Voxilaprevir: Difference between revisions
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{{Use dmy dates|date=January 2020}} |
{{Use dmy dates|date=January 2020}} |
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{{Infobox drug |
{{Infobox drug |
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| drug_name = |
| drug_name = |
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| type = |
| type = |
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| IUPAC_name = (1''R'',18''R'',20''R'',24''S'',27''S'',28''S'')-''N''-[(1''R'',2''R'')-2-(Difluoromethyl)-1-<nowiki>{[(</nowiki>1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-28-ethyl-13,13-difluoro-7-methoxy-24-(2-methyl-2-propanyl)-22,25-dioxo-2,21-dioxa-4,11,23,26-tetraazapentacyclo[24.2.1.0<sup>3,12</sup>.0<sup>5,10</sup>.0<sup>18,20</sup>]nonacosa-3(12),4,6,8,10-pentaene-27-carboxamide |
| IUPAC_name = (1''R'',18''R'',20''R'',24''S'',27''S'',28''S'')-''N''-[(1''R'',2''R'')-2-(Difluoromethyl)-1-<nowiki>{[(</nowiki>1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-28-ethyl-13,13-difluoro-7-methoxy-24-(2-methyl-2-propanyl)-22,25-dioxo-2,21-dioxa-4,11,23,26-tetraazapentacyclo[24.2.1.0<sup>3,12</sup>.0<sup>5,10</sup>.0<sup>18,20</sup>]nonacosa-3(12),4,6,8,10-pentaene-27-carboxamide |
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| image = Voxilaprevir.svg |
| image = Voxilaprevir.svg |
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| alt = |
| alt = |
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| caption = |
| caption = |
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<!-- Clinical data --> |
<!-- Clinical data --> |
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| pronounce = |
| pronounce = |
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| tradename = Vosevi (combination with [[sofosbuvir]] and [[velpatasvir]]) |
| tradename = Vosevi (combination with [[sofosbuvir]] and [[velpatasvir]]) |
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| Drugs.com = |
| Drugs.com = |
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| MedlinePlus = |
| MedlinePlus = |
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| licence_EU = |
| licence_EU = |
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| licence_US = |
| licence_US = |
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| pregnancy_AU = <!-- A/B1/B2/B3/C/D/X --> |
| pregnancy_AU = <!-- A/B1/B2/B3/C/D/X --> |
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| pregnancy_AU_comment = |
| pregnancy_AU_comment = |
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| pregnancy_US = <!-- A/B/C/D/X/N --> |
| pregnancy_US = <!-- A/B/C/D/X/N --> |
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| pregnancy_category = |
| pregnancy_category = |
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| routes_of_administration = |
| routes_of_administration = |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_AU_comment = |
| legal_AU_comment = |
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| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> |
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_DE = <!-- Anlage I, II, III --> |
| legal_DE = <!-- Anlage I, II, III --> |
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| legal_status = <!-- Free text --> |
| legal_status = <!-- Free text --> |
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<!-- Pharmacokinetic data --> |
<!-- Pharmacokinetic data --> |
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| bioavailability = |
| bioavailability = |
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| protein_bound = |
| protein_bound = |
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| metabolism = |
| metabolism = |
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| metabolites = |
| metabolites = |
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| onset = |
| onset = |
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| elimination_half-life = |
| elimination_half-life = |
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| duration_of_action = |
| duration_of_action = |
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| excretion = |
| excretion = |
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<!-- Identifiers --> |
<!-- Identifiers --> |
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| CAS_number = 1535212-07-7 |
| CAS_number = 1535212-07-7 |
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| PDB_ligand = L9P |
| PDB_ligand = L9P |
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| class = |
| class = |
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| ATCvet = |
| ATCvet = |
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| ATC_prefix = <!-- 'none' if uncategorised --> |
| ATC_prefix = <!-- 'none' if uncategorised --> |
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| ATC_suffix = |
| ATC_suffix = |
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| PubChem = 89921642 |
| PubChem = 89921642 |
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| DrugBank = |
| DrugBank = |
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| ChemSpiderID = 44209500 |
| ChemSpiderID = 44209500 |
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| UNII = 0570F37359 |
| UNII = 0570F37359 |
Latest revision as of 16:37, 28 January 2023
Clinical data | |
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Trade names | Vosevi (combination with sofosbuvir and velpatasvir) |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
PDB ligand | |
Chemical and physical data | |
Formula | C40H52F4N6O9S |
Molar mass | 868.94 g·mol−1 |
3D model (JSmol) | |
Density | 1.4±0.1[1] g/cm3 |
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Voxilaprevir is a hepatitis C virus (HCV) nonstructural (NS) protein 3/4A protease inhibitor (by Gilead) that is used in combination with sofosbuvir and velpatasvir.[2] The combination has the trade name Vosevi and received a positive opinion from the European Committee for Medicinal Products for Human Use in June 2017.[3]
On 18 July 2017, Vosevi was approved by the US Food and Drug Administration.[4]
References[edit]
- ^ "voxilaprevir_msds".
- ^ Heo YA, Deeks ED (April 2018). "Sofosbuvir/Velpatasvir/Voxilaprevir: A Review in Chronic Hepatitis C". Drugs. 78 (5): 577–587. doi:10.1007/s40265-018-0895-5. PMID 29546556. S2CID 4395880.
- ^ "Summary of opinion: Vosevi" (PDF). European Medicines Agency. 22 June 2017.
- ^ FDA approves Vosevi for Hepatitis C