1-methyl-4-phenylpyridinium
Structural formula | ||||||||||
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General | ||||||||||
Surname | 1-methyl-4-phenylpyridinium | |||||||||
other names |
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Molecular formula | C 12 H 12 N + | |||||||||
Brief description |
yellow solid (iodide) |
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properties | ||||||||||
Molar mass | ||||||||||
Physical state |
solid (iodide) |
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solubility |
soluble in water (> 10 mg / ml, iodide) |
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safety instructions | ||||||||||
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Toxicological data | ||||||||||
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
1-Methyl-4-phenylpyridinium (MPP + ) is a quaternary ammonium compound from the family of bipyridine herbicides.
The neurotoxin MPTP is oxidized to MPP + in the brain by the enzyme MAO-B . It causes Parkinson's in primates by killing certain dopamine- producing neurons in the substantia nigra .
use
The chloride salt of MPP + was marketed as a herbicide under the trade name Cyperquat and is structurally related to the herbicide paraquat . In the European Union and in Switzerland, 1-methyl-4-phenylpyridinium is not approved as a crop protection agent.
Individual evidence
- ↑ a b c d data sheet MPP + iodide ≥98% (HPLC), solid from Sigma-Aldrich , accessed on May 21, 2012 ( PDF ).
- ↑ Entry on 1-methyl-4-phenylpyridinium in the ChemIDplus database of the United States National Library of Medicine (NLM) .
- ↑ Salach, JI, Singer TP, Castagnoli N. Jr, Trevor A. (1984): Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTP. In: Biochem. Biophys. Res. Commun. 125 (2): pp. 831-835; PMID 6335034 .
- ↑ Singer, TP, Salach JI, Castagnoli N. Jr, Trevor A. (1986): Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases. In: Biochem. J. 235 (3): pp. 785-789; PMID 3489461 ; PMC 1146756 (free full text).
- ^ Directorate-General for Health and Food Safety of the European Commission: EU pesticide database ; Entry in the national directory of plant protection products in Switzerland ; Retrieved June 20, 2016.