2,2-diethyl-1,3-propanediol

Structural formula
General
Surname	2,2-diethyl-1,3-propanediol
other names	Prenderol
Molecular formula	C 7 H 16 O 2
Brief description	yellowish solid
External identifiers / databases
ECHA InfoCard	100.003.731
PubChem	8284
ChemSpider	7983
Wikidata	Q27273593
properties
Molar mass	132.20 g mol −1
Physical state	firmly
Melting point	59-61 ° C
boiling point	133-136 ° C (16 mmHg); 240.5 ° C;
solubility	very soluble in water, diethyl ether and ethanol
Refractive index	1.4574 (20 ° C)
safety instructions
GHS labeling of hazardous substances Caution
H and P phrases	H: 302-319
	P: 301 + 312 + 330-305 + 351 + 338
Toxicological data	850 mg kg −1 ( LD 50 , rat , oral ) ; 4240 mg kg −1 ( LD 50 , rabbit , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

2,2-Diethyl-1,3-propanediol is a chemical compound from the group of alkanediols .

properties

2,2-Diethyl-1,3-propanediol is a yellowish solid that is very soluble in water, diethyl ether and ethanol . The compound has a monoclinic crystal structure with the space group P 2 ₁ / c (space group no. 14) . Template: room group / 14

use

2,2-Diethyl-1,3-propanediol was previously used as a muscle relaxant under the name Prenderol. Later on, esters of the compound with a longer duration of action were developed.

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h data sheet 2,2-diethyl-1,3-propanediol, 99% from Sigma-Aldrich , accessed on December 3, 2018 ( PDF ).
↑ ^a ^b fishersci: Material Safety Data Sheet 2,2-Diethyl-1,3-propanediol, 99 +% , accessed on December 3, 2018
↑ ^a ^b W.LF Armarego: Purification of Laboratory Chemicals . Butterworth-Heinemann, 2017, ISBN 978-0-12-805456-7 , pp. 1138 ( limited preview in Google Book search).
↑ ^a ^b David R. Lide: CRC Handbook of Chemistry and Physics A Ready-reference Book of Chemical and Physical Data . CRC Press, 1995, ISBN 978-0-8493-0595-5 , pp. 188 ( limited preview in Google Book search).
^ University of Southampton: 2,2-diethyl-1,3-propanediol - eCrystals - University of Southampton , accessed December 3, 2018.
^ Basics and methods of clinical psychiatry . Springer-Verlag, 2013, ISBN 978-3-662-00726-6 , pp. 603 ( limited preview in Google Book search).
↑ J. Büchi: Fundamentals of drug research and synthetic drugs . Springer-Verlag, 2013, ISBN 978-3-0348-4019-4 , pp. 190 ( limited preview in Google Book Search).
↑ 3.0.CO; 2-A "> Audrey B. Mailer: Effects of mephenesin and prenderol on intellectual functions of mental patients. In: Journal of Clinical Psychology . 10, 1954, p. 283, doi : 10.1002 / 1097-4679 ( 195407) 10: 3 <283 :: AID-JCLP2270100322> 3.0.CO; 2-A .
↑ Irwin H. Slater, John P. O'Leary, EJ Pribyl: Some Attempts to Prolong the Duration of Action of 2,2-Diethyl-1,3-Propanediol (Prenderol). In: Journal of the American Pharmaceutical Association . 43, 1954, p. 547, doi : 10.1002 / jps.3030430909 .

[Sigma-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h data sheet 2,2-diethyl-1,3-propanediol, 99% from Sigma-Aldrich , accessed on December 3, 2018 ( PDF ).

[fishersci.com-2] shersci: Material Safety Data Sheet 2,2-Diethyl-1,3-propanediol, 99 +% , accessed on December 3, 2018

[W.L.F._Armarego-3] W.LF Armarego: Purification of Laboratory Chemicals . Butterworth-Heinemann, 2017, ISBN 978-0-12-805456-7 , pp. 1138 ( limited preview in Google Book search).

[David_R._Lide-4] David R. Lide: CRC Handbook of Chemistry and Physics A Ready-reference Book of Chemical and Physical Data . CRC Press, 1995, ISBN 978-0-8493-0595-5 , pp. 188 ( limited preview in Google Book search).

[chem.soton.ac.uk-5] University of Southampton: 2,2-diethyl-1,3-propanediol - eCrystals - University of Southampton , accessed December 3, 2018.

[6] Basics and methods of clinical psychiatry . Springer-Verlag, 2013, ISBN 978-3-662-00726-6 , pp. 603 ( limited preview in Google Book search).

[J._Büchi-7] J. Büchi: Fundamentals of drug research and synthetic drugs . Springer-Verlag, 2013, ISBN 978-3-0348-4019-4 , pp. 190 ( limited preview in Google Book Search).

[DOI10.1002/1097-4679(195407)10:3<283::AID-JCLP2270100322-8] 3.0.CO; 2-A "> Audrey B. Mailer: Effects of mephenesin and prenderol on intellectual functions of mental patients. In: Journal of Clinical Psychology . 10, 1954, p. 283, doi : 10.1002 / 1097-4679 ( 195407) 10: 3 <283 :: AID-JCLP2270100322> 3.0.CO; 2-A .

[DOI10.1002/jps.3030430909-9] Irwin H. Slater, John P. O'Leary, EJ Pribyl: Some Attempts to Prolong the Duration of Action of 2,2-Diethyl-1,3-Propanediol (Prenderol). In: Journal of the American Pharmaceutical Association . 43, 1954, p. 547, doi : 10.1002 / jps.3030430909 .