2-pyridine carbonitrile

Structural formula
General
Surname	2-pyridine carbonitrile
other names	2-cyanopyridine; Picolinonitrile; Pyridine-2-carbonitrile;
Molecular formula	C 6 H 4 N 2
Brief description	light brown solid
External identifiers / databases
EC number	202-880-3
ECHA InfoCard	100.002.619
PubChem	7522
ChemSpider	7241
Wikidata	Q27103368
properties
Molar mass	104.11 g mol −1
Physical state	firmly
density	1.081 g cm −3 (25 ° C)
Melting point	24-27 ° C
boiling point	212-215 ° C
solubility	soluble in water (67 g / l at 20 ° C); easily soluble in ethanol , diethyl ether and benzene ;
Refractive index	1.529 (20 ° C)
safety instructions
GHS labeling of hazardous substances Caution
H and P phrases	H: 302-319
	P: 301 + 312 + 330-305 + 351 + 338
Toxicological data	960 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

2-pyridine carbonitrile is a chemical compound from the group of pyridines and nitriles .

Occurrence

2-pyridine carbonitrile is found in tobacco smoke .

Extraction and presentation

2-pyridine carbonitrile can be obtained by the vapor phase ammoxidation of 2-methylpyridine with ammonia in the presence of air.

properties

2-pyridine carbonitrile is a light brown solid that is soluble in water.

use

2-pyridine carbonitrile is used as an important chemical intermediate for rimiterol hydrobromide and as a bronchodilator . It is also used as an intermediate for pharmaceuticals as well as for dyes and pigments and serves as a precursor of the respective amidate for protein modification by amidation .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Data sheet 2-Pyridinecarbonitrile, 99% from Sigma-Aldrich , accessed on March 7, 2019 ( PDF ).
↑ ^a ^b ^c Data sheet 2-Cyanopyridine, 99% from AlfaAesar, accessed on March 7, 2019 ( PDF )(JavaScript required) .
↑ David R. Lide: CRC Handbook of Chemistry and Physics A Ready-reference Book of Chemical and Physical Data . CRC Press, 1995, ISBN 978-0-8493-0595-5 , pp. 490 ( limited preview in Google Book search).
↑ Alan Rodgman, Thomas A. Perfetti: The Chemical Components of Tobacco and Tobacco Smoke . CRC Press, 2016, ISBN 978-1-4665-1552-9 , pp. 751 ( limited preview in Google Book search).
↑ Entry on 2-pyridinecarbonitrile in the Hazardous Substances Data Bank , accessed on March 7, 2019.

[Sigma-1] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Data sheet 2-Pyridinecarbonitrile, 99% from Sigma-Aldrich , accessed on March 7, 2019 ( PDF ).

[Alfa-2] Data sheet 2-Cyanopyridine, 99% from AlfaAesar, accessed on March 7, 2019 ( PDF )(JavaScript required) .

[David_R._Lide-3] David R. Lide: CRC Handbook of Chemistry and Physics A Ready-reference Book of Chemical and Physical Data . CRC Press, 1995, ISBN 978-0-8493-0595-5 , pp. 490 ( limited preview in Google Book search).

[Alan_Rodgman,_Thomas_A._Perfetti-4] Alan Rodgman, Thomas A. Perfetti: The Chemical Components of Tobacco and Tobacco Smoke . CRC Press, 2016, ISBN 978-1-4665-1552-9 , pp. 751 ( limited preview in Google Book search).

[HSDB-5] Entry on 2-pyridinecarbonitrile in the Hazardous Substances Data Bank , accessed on March 7, 2019.