4-chlorophenylacetonitrile

Structural formula
General
Surname	4-chlorophenylacetonitrile
other names	4-chlorobenzyl cyanide (p-chlorophenyl) acetonitrile
Molecular formula	C 8 H 6 ClN
Brief description	colorless and odorless solid
External identifiers / databases
CAS number 140-53-4 ECHA InfoCard 100,004,927 PubChem 241582 ChemSpider 211145 Wikidata Q27102330
properties
Molar mass	151.60 g mol −1
Physical state	firmly
density	1.190 g cm −3
Melting point	28-31 ° C
boiling point	141-143 ° C (11 mmHg )
Vapor pressure	0.133 mbar (20 ° C)
solubility	practically insoluble in water
Refractive index	1.5430 (20 ° C)
safety instructions
GHS labeling of hazardous substances danger H and P phrases H: 300-311-331-315-319-335 P: 261-302 + 352-305 + 351 + 338
Toxicological data	50 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

4-chlorophenylacetonitrile is a chemical compound belonging to the nitrile group .

Extraction and presentation

The compound can be obtained by reacting 4-chlorobenzyl chloride with sodium cyanide .

properties

4-chlorophenylacetonitrile is a colorless and odorless solid that is practically insoluble in water.

use

4-chlorophenylacetonitrile is used in the manufacture of drugs (for example chlorophenamine , pyrimethamine and sibutramine ).

Individual evidence

1. ↑ ^{a b c d e f g h i j k l} Data sheet 4-Chlorophenylacetonitrile, 98 +% from AlfaAesar, accessed on December 21, 2019 ( PDF )(JavaScript required) .
2. ↑ Google Patents: US4056509A - Preparation of benzyl cyanides - Google Patents , accessed December 21, 2019.
3. ^ A. Kleemann, J. Engel, B. Kutscher, D. Reichert, Axel Kleemann, Jürgen Engel, Bernhard Kutscher, Dietmar Reichert: Pharmaceutical Substances, 5th Edition, 2009 Syntheses, Patents and Applications of the most relevant APIs . Georg Thieme Verlag, 2014, ISBN 3-13-179525-5 ( limited preview in Google book search).