Enzacamen

Structural formula
General
Non-proprietary name	Enzacamen
other names	(3 E ) -1,7,7-trimethyl-3- (4-methylbenzylidene) bicyclo [2.2.1] heptan-2-one ( IUPAC ) ; 3- (4'-methylbenzylidene) camphor; 4-methylbenzylidene camphor; 4-MBC; 4-METHYLBENZYLIDENE CAMPHOR ( INCI ) ;
Molecular formula	C 18 H 22 O
Brief description	white crystalline powder
External identifiers / databases
EC number	253-242-6
ECHA InfoCard	100.048.386
PubChem	6434217
ChemSpider	4939160
DrugBank	DB11219
Wikidata	Q4637174
properties
Molar mass	254.37 g mol −1
Physical state	firmly
Melting point	66-68 ° C
solubility	soluble in methanol: 10 µg · ml −1 ; insoluble in water;
safety instructions
GHS labeling of hazardous substances Caution
H and P phrases	H: 361
	P: 281
Toxicological data	> 5000 mg kg −1 ( LD 50 , rat , oral ) ; > 2000 mg kg −1 ( LD 50 , rat , dermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Enzacamen ( 4-methylbenzylidenecamphor , abbreviation : 4-MBC) is a chemical compound that is used in sunscreen because it protects against UV-B radiation and infrared radiation . Enzacamen is a white powder.

cancer

According to a study by the Institute for Pharmacology and Toxicology at the University of Zurich , enzacamen accelerates the growth of cancer cells .

Admission

4-MBC is approved as a cosmetic ingredient in Europe by the EU and is tested in Canada by Health Canada . In the USA there has not yet been any testing or approval by the Food and Drug Administration ; in Japan the product is banned.

In the South Sea state of Palau , 4-MBC in sunscreen to protect coral reefs has been banned since January 2020. The ban is based on the results of a study published in 2017 on the pollution of the underwater world at Jellyfish Lake .

Trade names

Eusolex 6300, Parsol 5000

Individual evidence

↑ Entry on 4-METHYLBENZYLIDENE CAMPHOR in the CosIng database of the EU Commission, accessed on March 26, 2020.
↑ ^a ^b Entry 3- (4-Methylbenzylidene) -camphor on chemicalland21.com, accessed on June 29, 2014.
↑ ^a ^b ^c Entry enzacamen on pharmacopeia.cn, accessed on June 29, 2014.
↑ ^a ^b ^c ^d Data sheet 3- (4-methylbenzylidene) camphor from Sigma-Aldrich , accessed on March 26, 2020 ( PDF ).
↑ Use and effects of enzacamen on dermapproved.com , accessed June 29, 2014.
^ Sun Block has Endocrine Disruptor Chemicals , accessed June 29, 2014.
↑ Entry 3- (4'-Methylbenzylidene) -dl-camphor / Enzacamene in the CosIng Register of the European Commission, accessed on June 29, 2014.
^ The Republic of Palau Bans Sunscreen Chemicals to Protect its Coral Reefs and UNESCO World Heritage site - International Coral Reef Initiative. In: icriforum.org. November 4, 2018, accessed February 20, 2020 .
^ Coral Reef Research Foundation: Final Report - Sunscreen Pollution Analysis in Jellyfisch Lake , Palau, January 2017 ( PDF ).

[CosIng-1] Entry on 4-METHYLBENZYLIDENE CAMPHOR in the CosIng database of the EU Commission, accessed on March 26, 2020.

[cl21-2] Entry 3- (4-Methylbenzylidene) -camphor on chemicalland21.com, accessed on June 29, 2014.

[pharmacopeia.cn-3] Entry enzacamen on pharmacopeia.cn, accessed on June 29, 2014.

[Sigma-4] Data sheet 3- (4-methylbenzylidene) camphor from Sigma-Aldrich , accessed on March 26, 2020 ( PDF ).

[dermapproved.com-5] Use and effects of enzacamen on dermapproved.com , accessed June 29, 2014.

[mindfully.org-6] Sun Block has Endocrine Disruptor Chemicals , accessed June 29, 2014.

[ec.europa.eu-7] Entry 3- (4'-Methylbenzylidene) -dl-camphor / Enzacamene in the CosIng Register of the European Commission, accessed on June 29, 2014.

[8] The Republic of Palau Bans Sunscreen Chemicals to Protect its Coral Reefs and UNESCO World Heritage site - International Coral Reef Initiative. In: icriforum.org. November 4, 2018, accessed February 20, 2020 .

[9] Coral Reef Research Foundation: Final Report - Sunscreen Pollution Analysis in Jellyfisch Lake , Palau, January 2017 ( PDF ).