4-trifluoromethoxyaniline

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Structural formula
Structural formula of 4-trifluoromethoxyaniline
General
Surname 4-trifluoromethoxyaniline
other names
  • α, α, α-trifluoro- p- anisidine
  • 4- (trifluoromethoxy) aniline
Molecular formula C 7 H 6 F 3 NO
Brief description

yellow liquid

External identifiers / databases
CAS number 461-82-5
EC number 207-317-5
ECHA InfoCard 100.006.653
PubChem 600848
ChemSpider 522366
Wikidata Q27286099
properties
Molar mass 177.12 g mol −1
Physical state

liquid

density

1.32 g cm −3 (20 ° C)

boiling point

73–75 ° C (13 hPa)

Refractive index

1.463 (20 ° C)

safety instructions
GHS labeling of hazardous substances
05 - Corrosive 06 - Toxic or very toxic 08 - Dangerous to health

danger

H and P phrases H: 301-310-315-318-373
P: 280-301 + 310-302 + 350-305 + 351 + 338-310
Toxicological data
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

4-Trifluoromethoxyaniline is a chemical compound of fluorine from the group of aniline derivatives .

Extraction and presentation

4-Trifluoromethoxyaniline can be obtained from the corresponding amide by Hofmann's amide degradation .

properties

4-trifluoromethoxyaniline is a yellow liquid.

use

4-Trifluoromethoxyaniline can be used as an intermediate in the manufacture of pharmaceuticals and agrochemicals.

literature

  • M. Tugnait, EM Lenz, P. Phillips, M. Hofmann, M. Spraul, JC Lindon, JK Nicholson, ID Wilson: The metabolism of 4-trifluoromethoxyaniline and [13C] -4-trifluoromethoxyacetanilide in the rat: detection and identification of metabolites excreted in the urine by NMR and HPLC-NMR. In: J Pharm Biomed Anal. 28, 2002, pp. 875-885, PMID 12039629 .

Individual evidence

  1. ↑ a b c d e f g h i j data sheet 4- (Trifluoromethoxy) aniline, 98% from Sigma-Aldrich , accessed on June 20, 2018 ( PDF ).
  2. ↑ Andrei A. Gakh, Kenneth L. Kirk: Fluorinated Heterocycles . American Chemical Society, 2009, ISBN 978-0-8412-6953-8 , pp. 308 ( limited preview in Google Book search).
  3. ↑ Thomas A. Unger: Pesticide Synthesis Handbook . William Andrew, 1996, ISBN 0-8155-1853-6 , pp. 1051 ( limited preview in Google Book search).