9-aminoacridine

Structural formula
General
Surname	9-aminoacridine
other names	9-acridinylamine; Aminacrine;
Molecular formula	C 1 3 H 1 0 N 2
Brief description	yellow solid
External identifiers / databases
ECHA InfoCard	100.001.814
PubChem	7019
ChemSpider	6752
DrugBank	DB11561
Wikidata	Q513937
Drug information
ATC code	D08 AA02
properties
Molar mass	194.23 g mol −1
Physical state	firmly
Melting point	231-235 ° C
solubility	practically insoluble in water
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Caution
H and P phrases	H: 315
	P: 302 + 352
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

9-Aminoacridine is a chemical compound from the acridines group .

Extraction and presentation

9-Aminoacridine can be obtained by heating N- phenylanthranilic acid with phosphorus pentachloride and then with ammonium carbonate in phenol .

It can also be obtained by reacting acridine with sodium amide .

properties

9-Aminoacridine is a yellow solid that is practically insoluble in water. The hydrochloride is a yellow, crystalline, odorless, bitter-tasting powder that is soluble in water and ethanol , slightly soluble in physiological saline and practically insoluble in diethyl ether and chloroform . The hemihydrate has an orthorhombic crystal structure with the space group Fddd (space group no. 70) . Template: room group / 70

use

9-Aminoacridine is a highly fluorescent aminoacridine dye that acts as a powerful mutagen in viruses and bacteria. The hydrochloride is used as an antiseptic .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f ^g Data sheet 9-Aminoacridine (PDF) from Merck , accessed on July 12, 2020.
^ ^A ^b ^c Hans Hermann Julius Hager, Walther Kern, Paul Heinz List, Hermann Josef Roth: Hager's Handbook of Pharmaceutical Practice For pharmacists, drug manufacturers, doctors and medical officials: Active ingredient groups II, chemicals and drugs (A-AL) . Springer-Verlag, 2013, ISBN 978-3-662-25655-8 , pp. 15 ( limited preview in Google Book search).
↑ Angewandte Chemie: Newer Methods in Preparative Organic Chemistry . Verlag Chemie, 1949, OCLC 14487295 , p. 69 ( limited preview in Google Book search).
^ R. Morrin Acheson: Acridines . John Wiley & Sons, 2009, ISBN 978-0-470-18809-5 , pp. 122 ( limited preview in Google Book search).
↑ Data sheet 9-Aminoacridine, matrix substance for MALDI-MS, ≥99.5% (HPLC) from Sigma-Aldrich , accessed on July 12, 2020 ( PDF ).

[Merck-1] ↑ ^a ^b ^c ^d ^e ^f ^g Data sheet 9-Aminoacridine (PDF) from Merck , accessed on July 12, 2020.

[Hans_Hermann_Julius_Hager-2] A ^b ^c Hans Hermann Julius Hager, Walther Kern, Paul Heinz List, Hermann Josef Roth: Hager's Handbook of Pharmaceutical Practice For pharmacists, drug manufacturers, doctors and medical officials: Active ingredient groups II, chemicals and drugs (A-AL) . Springer-Verlag, 2013, ISBN 978-3-662-25655-8 , pp. 15 ( limited preview in Google Book search).

[Angewandte_Chemie-3] Angewandte Chemie: Newer Methods in Preparative Organic Chemistry . Verlag Chemie, 1949, OCLC 14487295 , p. 69 ( limited preview in Google Book search).

[R._Morrin_Acheson-4] R. Morrin Acheson: Acridines . John Wiley & Sons, 2009, ISBN 978-0-470-18809-5 , pp. 122 ( limited preview in Google Book search).

[Sigma-5] Data sheet 9-Aminoacridine, matrix substance for MALDI-MS, ≥99.5% (HPLC) from Sigma-Aldrich , accessed on July 12, 2020 ( PDF ).