Alpha-naphthylthiourea

Structural formula
General
Surname	Alpha-naphthylthiourea
other names	1-naphthylthiourea alpha-naphthylthiourea α-naphthylthiourea Krysid Antu
Molecular formula	C 11 H 10 N 2 S
Brief description	in the pure form colorless, as a technical product reddish, odorless solid
External identifiers / databases
CAS number 86-88-4 EC number 201-706-3 ECHA InfoCard 100.001.552 PubChem 736366 Wikidata Q413532
properties
Molar mass	202.28 g mol −1
Physical state	firmly
Melting point	198 ° C
Vapor pressure	negligible
solubility	Very sparingly soluble in water (0.6 g l −1 at 25 ° C)
safety instructions
GHS hazard labeling from  Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary danger H and P phrases H: 300-351 P: 301 + 330 + 331
MAK	Switzerland: 0.3 ml m −3 (measured as inhalable dust )
Toxicological data	6 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Alpha-naphthylthiourea is a poison from the group of thiourea derivatives that is mainly used in rat control ( rodenticide ) .

properties

Alpha-naphthylthiourea is colorless in its pure form and, as a technical product, reddish, odorless and flammable solid. It decomposes before it reaches its boiling point, producing sulfur oxides and nitrogen oxides.

use

Alpha-naphthylthiourea is mainly used against brown rats and to some extent also against voles . Since it is tasteless to rats, it can easily be used in bait. It causes fatal pulmonary edema in rats . The LD ₅₀ is 6.4 to 7.4 mg / kg of the rat. An active ingredient concentration of about 1% (10 g / kg bait) was used in the poison bait and a concentration of 30% (300 g / kg) in adhesive dusts. Other rodents ( house mouse , black rat ) are not sensitive. Today it is no longer used because an impurity from production ( 1-naphthylamine ) is carcinogenic. Nowadays, coumarin derivatives are mostly used instead of alpha-naphthylthiourea .

safety instructions

Alpha-naphthylthiourea is suspected of having a carcinogenic effect.

Individual evidence

1. ↑ ^{a b c d e f g h i} Entry on Antu in the GESTIS substance database of the IFA , accessed on February 1, 2016 (JavaScript required)
2. ↑ Entry on Antu in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on February 1, 2016. Manufacturers or distributors can expand the harmonized classification and labeling .
3. ↑ Swiss Accident Insurance Fund (Suva): Limits - Current MAK and BAT values (search for 86-88-4 or alpha-naphthylthiourea ), accessed on November 2, 2015.