Alphapapillomavirus

Alphapapillomavirus
Systematics
Classification : Viruses Area : Monodnaviria Empire : Shotokuvirae Phylum : Cossaviricota Class : Papovaviricetes Order : Zurhausenvirales Family : Papillomaviridae Subfamily : Firstpapillomavirinae Genre : Alphapapillomavirus
Taxonomic characteristics
Genome : dsDNA circular Baltimore : Group 1 Symmetry : icosahedral Cover : no
Scientific name
Alphapapillomavirus
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NCBI  Taxonomy: 333750 ViralZone ( ExPASy , SIB): 187 ICTVdB Virus Code : 00.099.0.02

The genus Alphapapillomavirus combines viruses from the family Papillomaviridae , whose gene for the viral E5 protein ( English early protein 5 ) is highly conserved within this group. This differentiates them from papilloma viruses with a bovine E5 variant or without an E5 protein. The E5 protein interacts with the cellular EGF receptor during virus replication . Members of the genus mainly infect the oral and anogenital mucosa in humans and other primates ( chimpanzees , bonobos , rhesus monkeys ). Among them are the most important human papilloma viruses (HPV). The genus Alphapapillomavirus is the most species-rich within the family and is phylogenetically closest to the genus Betapapillomavirus .

A new virus isolate in polar bears is very close to the genus Alphapapillomavirus . A phylogenetically very archaic genome sequence closely related to the genus showed an isolate in domestic pigs . However, both isolates have not yet been provisionally classified as species of the genus.

Systematics

The systematics of the genus Alphapapillomavirus has since been reorganized ( ICTV as of November 2018) into species names Alphapapillomavirus 1 to 14 . Here is the previous taxonomy:

• Family Papillomaviridae

• Genus Alphapapillomavirus

• Species Human Papillomavirus 2 HPV-2

Subtypes: HPV-2, HPV-27, HPV-57

• Species Human Papillomavirus 6 HPV-6

Subtypes: HPV-6, 11, 13, 44, 74, dwarf chimpanzee papillomavirus 1 and chimpanzee 1 (PCPV-1, PCPV-1C)

• Species Human Papillomavirus 7 HPV-7

Subtypes: HPV-7, 40, 43, HPV-cand91

• Species Human Papillomavirus 10 HPV-10

Subtypes: HPV-3, 10, 28, 29, 77, 78, 94

• Species Human Papillomavirus 16 HPV-16

Subtypes: HPV-16, 31, 33, 35, 52, 58, 67

• Species Human Papillomavirus 18 HPV-18

Subtypes: HPV-18, 39, 45, 59, 68, 70, HPV-cand85

• Species Human Papillomavirus 26 HPV-26

Subtypes: HPV-26, 51, 69, 82

• Species Human Papillomavirus 32 HPV-32

Subtypes: HPV-32 and 42

• Species Human Papillomavirus 34 HPV-34

Subtypes: HPV-34 and 73

• Species Human Papillomavirus 53 HPV-53

Subtypes: HPV-30, 53, 56, 66

• Species Human Papillomavirus 54 HPV-54

Subtype: HPV-54

• Species Human Papillomavirus 61 HPV-61

Subtypes: HPV-61, 72, 81, 83, 84, cand62, cand86, cand87, cand89

• Species Human Papillomavirus 71 HPV-71

Subtype: HPV-71

• Species Human Papillomavirus cand90 HPV-cand90

Subtype: HPV-cand90

• Species rhesus monkey papillomavirus 1 RhPV-1

Subtype: RhPV-1

swell

• E.-M. de Villiers et al .: Genus Alphapapillomavirus . In: CM Fauquet, MA Mayo et al. : Eighth Report of the International Committee on Taxonomy of Viruses . London, San Diego, 2005 pp. 243ff ISBN 0-12-249951-4
• Peter M. Howley , Douglas R. Lowy: Papillomaviruses . In: David M. Knipe, Peter M. Howley (eds.-in-chief): Fields' Virology . 5th edition, Volume 2, Philadelphia 2007, pp. 2299ff ISBN 0-7817-6060-7

Individual evidence

1. ↑ ^{a b c d e} ICTV: ICTV Taxonomy history: Alphapapillomavirus 1 , EC 51, Berlin, Germany, July 2019; Email ratification March 2020 (MSL # 35)
2. ↑ H. Stevens et al. : Novel papillomavirus isolated from the oral mucosa of a polar bear does not cluster with other papillomaviruses of carnivores . Vet. Microbiol. (2008) 129 (1-2): pp. 108-116 PMID 18215475
3. ↑ H. Stevens et al. : Isolation and cloning of two variant papillomaviruses from domestic pigs: Sus scrofa papillomaviruses type 1 variants a and b. J. Gen. Virol. (2008) 89 (Pt 10): pp. 2475-2481 PMID 18796716