Atipamezole

Structural formula
General
Non-proprietary name	Atipamezole
other names	4- (2-Ethyl-2,3-dihydro-1 H -inden-2-yl) -1 H -imidazole
Molecular formula	C 14 H 12 N 2
External identifiers / databases
CAS number 104054-27-5 (atipamezole) 104075-48-1 (atipamezole hydrochloride ) PubChem 71310 ChemSpider 64427 DrugBank DB11481 Wikidata Q413894
Drug information
ATC code	Q V03AB90
Mechanism of action	α 2 -adrenoreceptor antagonist
properties
Molar mass	212.29 g · mol -1 (atipamezole) 248.75 g · mol -1 (· atipamezole hydrochloride)
Physical state	firmly
Melting point	211–215 ° C (atipamezole hydrochloride)
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS labeling of hazardous substances no GHS pictograms H and P phrases H: no H-phrases P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Atipamezole is a α ₂ -adrenoreceptor - antagonist and is used in veterinary medicine, to the sedative and analgesic effects of α ₂ -adrenoceptor agonists ( medetomidine , detomidine , dexmedetomidine , xylazine ) set aside. The active ingredient also has little effect on α ₁ -adrenoreceptors. It is eliminated through the kidneys .

Atipamezole has about 100 times more specificity for α ₂ -adrenoreceptors than yohimbine . It can also be used as an antidote for Amitraz overdose . The drug is administered intravenously or intramuscularly.

Individual evidence

1. ↑ Mary Adele J. O'Neil: The Merck Index : An Encyclopedia of Chemicals, Drugs, and Biologicals . Ed .: Merck & Co., Inc. 14th Edition. Elsevier, Whitehouse Station, NJ, USA 2006, ISBN 978-0-911910-00-1 .
2. ↑ ^{a b} data sheet atipamezole from Sigma-Aldrich , accessed on May 13, 2011 ( PDF ).

Trade names

Alzane, Antisedan, Atipam, Nosedorm, Revertor, Tipafar

Web links

• Atipamezole entry at Vetpharm, accessed August 4, 2012.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !