Atipamezole
Structural formula | ||||||||||||||||
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General | ||||||||||||||||
Non-proprietary name | Atipamezole | |||||||||||||||
other names |
4- (2-Ethyl-2,3-dihydro-1 H -inden-2-yl) -1 H -imidazole |
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Molecular formula | C 14 H 12 N 2 | |||||||||||||||
External identifiers / databases | ||||||||||||||||
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Drug information | ||||||||||||||||
ATC code | ||||||||||||||||
Mechanism of action |
α 2 -adrenoreceptor antagonist |
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properties | ||||||||||||||||
Molar mass | ||||||||||||||||
Physical state |
firmly |
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Melting point |
211–215 ° C (atipamezole hydrochloride) |
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safety instructions | ||||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Atipamezole is a α 2 -adrenoreceptor - antagonist and is used in veterinary medicine, to the sedative and analgesic effects of α 2 -adrenoceptor agonists ( medetomidine , detomidine , dexmedetomidine , xylazine ) set aside. The active ingredient also has little effect on α 1 -adrenoreceptors. It is eliminated through the kidneys .
Atipamezole has about 100 times more specificity for α 2 -adrenoreceptors than yohimbine . It can also be used as an antidote for Amitraz overdose . The drug is administered intravenously or intramuscularly.
Individual evidence
- ↑ Mary Adele J. O'Neil: The Merck Index : An Encyclopedia of Chemicals, Drugs, and Biologicals . Ed .: Merck & Co., Inc. 14th Edition. Elsevier, Whitehouse Station, NJ, USA 2006, ISBN 978-0-911910-00-1 .
- ↑ a b data sheet atipamezole from Sigma-Aldrich , accessed on May 13, 2011 ( PDF ).
Trade names
Alzane, Antisedan, Atipam, Nosedorm, Revertor, Tipafar
Web links
- Atipamezole entry at Vetpharm, accessed August 4, 2012.