Azidamfenicol

Structural formula
General
Non-proprietary name	Azidamfenicol
other names	2-Azido- N - [(1 R , 2 R ) -1,3-dihydroxy-1- (4-nitrophenyl) propan-2-yl] acetamide ( IUPAC ) ; D - (-) - threo-2- (azidoacetamido) -1- (4-nitrophenyl) propane-1,3-diol;
Molecular formula	C 11 H 13 N 5 O 5
External identifiers / databases
EC number	237-552-9
ECHA InfoCard	100.034.125
PubChem	62858
ChemSpider	56590
Wikidata	Q425029
Drug information
ATC code	S01 AA25
properties
Molar mass	295.25 g · mol -1
Physical state	firmly
Melting point	107 ° C
solubility	20 g l −1 in water
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
H and P phrases	H: 302
	P: ?
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Azidamfenicol is a drug from the group of amphenicol - antibiotic that is structurally the chloramphenicol resembles.

It is only suitable for topical use . It can be used in the form of eye drops to treat bacterial conjunctivitis . In contrast to chloramphenicol, azidamfenicol is readily soluble in water. The spectrum of sensitive pathogens is similar to that of chloramphenicol. Ready-made preparations are not or no longer on the market in Germany, Austria and Switzerland.

chemistry

The chemical synthesis of azidamfenicol starting from azidoacetic acid methyl ester is described in the literature.

Individual evidence

↑ ^a ^b Entry on azidamfenicol in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on December 17, 2019.
↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of azidamfenicol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), which was retrieved on December 17, 2019, is reproduced from a self-classification by the distributor .
↑ Product information Posifenicol 1% . As of June 2006.
↑ Axel Kleemann , Jürgen Engel, Bernd Kutscher and Dieter Reichert: Pharmaceutical Substances , 4th edition (2000) 2 volumes published by Thieme-Verlag Stuttgart, pp. 162-163, ISBN 978-1-58890-031-9 ; online since 2003 with biannual additions and updates.

[ChemIDplus-1] Entry on azidamfenicol in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on December 17, 2019.

[2] Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of azidamfenicol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), which was retrieved on December 17, 2019, is reproduced from a self-classification by the distributor .

[3] Product information Posifenicol 1% . As of June 2006.

[Kleemann-4] Axel Kleemann , Jürgen Engel, Bernd Kutscher and Dieter Reichert: Pharmaceutical Substances , 4th edition (2000) 2 volumes published by Thieme-Verlag Stuttgart, pp. 162-163, ISBN 978-1-58890-031-9 ; online since 2003 with biannual additions and updates.