Azidocillin
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Surname | Azidocillin | |||||||||||||||||||||
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Molecular formula | C 16 H 17 N 5 O 4 S | |||||||||||||||||||||
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Molar mass | 375.40 g mol −1 | |||||||||||||||||||||
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firmly |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Azidocillin is an organic chemical compound belonging to the group of β-lactam antibiotics , more precisely the benzylpenicillins (beta-lactamase-sensitive penicillins). It was first patented by Beechem (now GlaxoSmithKline ) in 1966 . The narrow spectrum of activity includes only Gram-positive aerobic and anaerobic bacteria. The sodium salt is used, among other things, to treat streptococci and pneumococci.
properties
Azidocillin is acid-stable, which is why it can not only be administered parenterally, but also orally. The bioavailability of the substance is around 70% and is not affected by food. The half-life is similar to that of phenoxypenicillin and is estimated to be 30 to 60 minutes.
Individual evidence
- ^ A. Kleemann , J. Engel, B. Kutscher, D. Reichert: Pharmaceutical Substances Online . Thieme, Stuttgart, accessed on April 1, 2020.
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006, ISBN 978-0-911910-00-1 , pp. 154.
- ↑ Entry on azidocillin. In: Römpp Online . Georg Thieme Verlag, accessed on April 1, 2020.
- ↑ a b D. Adam, K.-F. Bodmann, W. Elies, C. Lebert, K. Naber, K. Simons, F. Vogel, H. Wacha: Oral antibiotics in clinic and practice; Practice-oriented recommendations for antibiotic therapy of mild to moderate bacterial infections in adults in outpatient and inpatient settings. Springer, Heidelsberg, 2009, ISBN 978-3-642-00521-3 , pp. 12-13.
- ↑ T. Bruis, D. Förster, HJ Grofe, H. Weuta: Serum and tonsil concentration after injection of azidocillin. In: Infection, Vol. 5, No. 1, Springer, 1977, pp. 26-31, doi 10.1007 / BF01639106 .