Azidocillin

Structural formula
General
Surname	Azidocillin
other names	6- ( D- α-azidophenylacetamido) penicillanic acid; (2 S , 5 R , 6 R ) -6 - {[(2 R ) -2-azido-2-phenylacetyl] amino} -3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2 .0] heptane-2-carboxylic acid;
Molecular formula	C 16 H 17 N 5 O 4 S
External identifiers / databases
EC number	241-278-5
ECHA InfoCard	100.037.510
PubChem	15574941
ChemSpider	16735689
DrugBank	DB08795
Wikidata	Q4832566
Drug information
ATC code	J01 CE04
Drug class	β-lactam antibiotic
Mechanism of action	Inhibition of cell wall synthesis
properties
Molar mass	375.40 g mol −1
Physical state	firmly
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Azidocillin is an organic chemical compound belonging to the group of β-lactam antibiotics , more precisely the benzylpenicillins (beta-lactamase-sensitive penicillins). It was first patented by Beechem (now GlaxoSmithKline ) in 1966 . The narrow spectrum of activity includes only Gram-positive aerobic and anaerobic bacteria. The sodium salt is used, among other things, to treat streptococci and pneumococci.

properties

Azidocillin is acid-stable, which is why it can not only be administered parenterally, but also orally. The bioavailability of the substance is around 70% and is not affected by food. The half-life is similar to that of phenoxypenicillin and is estimated to be 30 to 60 minutes.

Individual evidence

^ A. Kleemann , J. Engel, B. Kutscher, D. Reichert: Pharmaceutical Substances Online . Thieme, Stuttgart, accessed on April 1, 2020.
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006, ISBN 978-0-911910-00-1 , pp. 154.
↑ Entry on azidocillin. In: Römpp Online . Georg Thieme Verlag, accessed on April 1, 2020.
↑ ^a ^b D. Adam, K.-F. Bodmann, W. Elies, C. Lebert, K. Naber, K. Simons, F. Vogel, H. Wacha: Oral antibiotics in clinic and practice; Practice-oriented recommendations for antibiotic therapy of mild to moderate bacterial infections in adults in outpatient and inpatient settings. Springer, Heidelsberg, 2009, ISBN 978-3-642-00521-3 , pp. 12-13.
↑ T. Bruis, D. Förster, HJ Grofe, H. Weuta: Serum and tonsil concentration after injection of azidocillin. In: Infection, Vol. 5, No. 1, Springer, 1977, pp. 26-31, doi 10.1007 / BF01639106 .

[Pharmaceutical_Substances-1] A. Kleemann , J. Engel, B. Kutscher, D. Reichert: Pharmaceutical Substances Online . Thieme, Stuttgart, accessed on April 1, 2020.

[NV-2] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[MERCK_Index-3] The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006, ISBN 978-0-911910-00-1 , pp. 154.

[Römpp-4] Entry on azidocillin. In: Römpp Online . Georg Thieme Verlag, accessed on April 1, 2020.

[Adam-5] D. Adam, K.-F. Bodmann, W. Elies, C. Lebert, K. Naber, K. Simons, F. Vogel, H. Wacha: Oral antibiotics in clinic and practice; Practice-oriented recommendations for antibiotic therapy of mild to moderate bacterial infections in adults in outpatient and inpatient settings. Springer, Heidelsberg, 2009, ISBN 978-3-642-00521-3 , pp. 12-13.

[6] T. Bruis, D. Förster, HJ Grofe, H. Weuta: Serum and tonsil concentration after injection of azidocillin. In: Infection, Vol. 5, No. 1, Springer, 1977, pp. 26-31, doi 10.1007 / BF01639106 .