Benzylpenicillin-Benzathine

Structural formula
General
Non-proprietary name	Benzylpenicillin-Benzathine
other names	Benzathine benzyl penicillin; N , N '-Bis (phenylmethyl) -1,2-ethanediaminiumbis [(2 S , 5 R , 6 R ) -3,3-dimethyl-7-oxo-6- (2-phenylacetamido) -4-thia-1 -azabicyclo [3.2.0] heptane-2-carboxylate] ( IUPAC );
Molecular formula	C 48 H 56 N 6 O 8 S 2
External identifiers / databases
EC number	216-260-5
ECHA InfoCard	100,014,782
PubChem	15232
ChemSpider	14498
DrugBank	DB09323
Wikidata	Q868435
Drug information
ATC code	J01 CE08
properties
Molar mass	909.12 g · mol -1
Physical state	firmly
Melting point	123-124 ° C
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Benzylpenicillin-Benzathine or Benzathine-Benzylpenicillin (also benzathine penicillin ) is a medicinal substance and a salt of benzylpenicillin (penicillin G). It is used, among other things, for the long-term treatment of syphilis and for prophylaxis against relapse in rheumatic fever.

The formation of salts with N , N -dibenzylethylenediamine creates a compound (“depot penicillin”) that is only sparingly soluble in water, which after intramuscular injection in the tissue depot is slowly hydrolyzed to form the pharmacologically active benzyl penicillin and then absorbed. Depending on the dosage and sensitivity to the pathogen, therapeutically effective serum levels can be maintained for at least two weeks.

The antibiotic was patented by the Wyeth company in 1953 . Today the active ingredient is on the market as a generic . In 1977, Benzylpenicillin-Benzathine was added to the World Health Organization 's list of Essential Medicines .

Finished medicinal products

Tardocillin (D), Pendysin (D)

Individual evidence

↑ ^a ^b Entry on Benzylpenicillin-Benzathine. In: Römpp Online . Georg Thieme Verlag, accessed on December 16, 2012.
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ Rossi S. (Ed.): Australian Medicines Handbook . Australian Medicines Handbook, Adelaide 2006, ISBN 0-9757919-2-3 .
↑ E. Mutschler et al .: Mutschler drug effects. Pharmacology - Clinical Pharmacology - Toxicology . 10th edition. WVG Stuttgart 2012, p. 745.
↑ Technical information Tardocillin, as of April 2011.

[Römpp-1] Entry on Benzylpenicillin-Benzathine. In: Römpp Online . Georg Thieme Verlag, accessed on December 16, 2012.

[NV-2] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[3] Rossi S. (Ed.): Australian Medicines Handbook . Australian Medicines Handbook, Adelaide 2006, ISBN 0-9757919-2-3 .

[4] E. Mutschler et al .: Mutschler drug effects. Pharmacology - Clinical Pharmacology - Toxicology . 10th edition. WVG Stuttgart 2012, p. 745.

[5] Technical information Tardocillin, as of April 2011.