Bibrocathol
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Non-proprietary name | Bibrocathol | |||||||||||||||
other names |
4,5,6,7-tetrabromo-1,3, λ 2 -benzodioxabismol ( IUPAC ) |
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Molecular formula | C 6 HBiBr 4 O 3 | |||||||||||||||
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properties | ||||||||||||||||
Molar mass | 649,67 g · mol -1 | |||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Bibrocathol is a bismuth-containing drug from the group of antiseptics . It is used in the eye area , for example in the case of inflammation of the eyelid rims , seborrhea or colonization of staphylococci in the eye area. Bibrocathol subject in Germany the pharmacies duty and is under the trade names Posiformin ® offered as eye ointment with 2% active ingredient. It was formerly available as Noviform ® with 1, 2, 3 and 5% active ingredient content . It was patented in 1908 as an antiseptic by the Heyden chemical factory .
Presentation and extraction
The synthesis of Bibrocathol starts from catechol , which is completely brominated to 3,4,5,6-tetrabromopychol in the first step . The reaction with bismuth (III) oxide then gives the target compound in the second step.
Pharmacological properties
Bibrocathol, which is sparingly soluble in water, has extremely low penetration into the eye. There is no significant systemic absorption of Bibrocathol after topical application. Absorbed bismuth salts are mainly excreted via the kidneys. The mechanism of action discussed is the precipitation of proteins and the blockade of thiol groups in enzymes.
Individual evidence
- ↑ harmonized classification for this substance . A labeling of Bibrocathol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), retrieved on July 19, 2019, is reproduced from a self-classification by the distributor . There is not yet a
- ↑ Waldemar Ternes: Biochemistry of the elements: Inorganic chemistry of biological processes . Springer DE, 2013, ISBN 3-8274-3020-8 , pp. 331 ( limited preview in Google Book search).
- ↑ Pharmacy review: Posiformin 2% eye ointment - package insert / information ( memento from September 23, 2015 in the Internet Archive ), accessed on May 14, 2014
- ^ Muller: European Drug Index: European Drug Registrations, Fourth Edition . CRC Press, 1998, ISBN 3-7692-2114-1 , pp. 913 ( limited preview in Google Book search).
- ↑ Entry on Bibrocathol. In: Römpp Online . Georg Thieme Verlag, accessed on May 14, 2014.
- ^ A. Kleemann , J. Engel, B. Kutscher, D. Reichert: Pharmaceutical Substances - Synthesis, Patents, Applications , 4th edition (2001), Thieme-Verlag Stuttgart, ISBN 978-1-58890-031-9 .
- ↑ Open Drug Database: ODDB.org: Fachinformation , accessed on May 14, 2014.