Bibrocathol

Structural formula
General
Non-proprietary name	Bibrocathol
other names	4,5,6,7-tetrabromo-1,3, λ 2 -benzodioxabismol ( IUPAC )
Molecular formula	C 6 HBiBr 4 O 3
External identifiers / databases
CAS number 6915-57-7 EC number 230-023-3 ECHA InfoCard 100.027.294 PubChem 16683103 Wikidata Q681387
Drug information
ATC code	S01 AX05
Drug class	antiseptic
properties
Molar mass	649,67 g · mol -1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS labeling of hazardous substances no GHS pictograms H and P phrases H: no H-phrases P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Bibrocathol is a bismuth-containing drug from the group of antiseptics . It is used in the eye area , for example in the case of inflammation of the eyelid rims , seborrhea or colonization of staphylococci in the eye area. Bibrocathol subject in Germany the pharmacies duty and is under the trade names Posiformin ^® offered as eye ointment with 2% active ingredient. It was formerly available as Noviform ^® with 1, 2, 3 and 5% active ingredient content . It was patented in 1908 as an antiseptic by the Heyden chemical factory .

Presentation and extraction

The synthesis of Bibrocathol starts from catechol , which is completely brominated to 3,4,5,6-tetrabromopychol in the first step . The reaction with bismuth (III) oxide then gives the target compound in the second step.

Pharmacological properties

Bibrocathol, which is sparingly soluble in water, has extremely low penetration into the eye. There is no significant systemic absorption of Bibrocathol after topical application. Absorbed bismuth salts are mainly excreted via the kidneys. The mechanism of action discussed is the precipitation of proteins and the blockade of thiol groups in enzymes.

Individual evidence

1. ↑ There is not yet a harmonized classification for this substance . A labeling of Bibrocathol in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), retrieved on July 19, 2019, is reproduced from a self-classification by the distributor .
2. ↑ Waldemar Ternes: Biochemistry of the elements: Inorganic chemistry of biological processes . Springer DE, 2013, ISBN 3-8274-3020-8 , pp. 331 ( limited preview in Google Book search).
3. ↑ Pharmacy review: Posiformin 2% eye ointment - package insert / information ( memento from September 23, 2015 in the Internet Archive ), accessed on May 14, 2014
4. ^ Muller: European Drug Index: European Drug Registrations, Fourth Edition . CRC Press, 1998, ISBN 3-7692-2114-1 , pp. 913 ( limited preview in Google Book search).
5. ↑ Entry on Bibrocathol. In: Römpp Online . Georg Thieme Verlag, accessed on May 14, 2014.
6. ^ A. Kleemann , J. Engel, B. Kutscher, D. Reichert: Pharmaceutical Substances - Synthesis, Patents, Applications , 4th edition (2001), Thieme-Verlag Stuttgart, ISBN 978-1-58890-031-9 .
7. ↑ Open Drug Database: ODDB.org: Fachinformation , accessed on May 14, 2014.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !