Pyruvic acid methyl ester

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Structural formula
Structural formula of methyl pyruvate
General
Surname Pyruvic acid methyl ester
other names
  • Methylpyruvate
  • 2-oxopropionic acid methyl ester
Molecular formula C 4 H 6 O 3
Brief description

colorless to yellowish liquid

External identifiers / databases
CAS number 600-22-6
EC number 209-987-4
ECHA InfoCard 100.009.081
PubChem 11748
ChemSpider 11255
Wikidata Q27122826
properties
Molar mass 102.09 g mol −1
Physical state

liquid

density

1.13 g cm −3

Melting point

−30 ° C

boiling point

137 ° C

solubility
Refractive index

1.404 (20 ° C)

safety instructions
GHS labeling of hazardous substances
02 - Highly / extremely flammable

Caution

H and P phrases H: 226
P: 261
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

Pyruvic acid methyl ester is a chemical compound from the group of carboxylic acid esters .

Extraction and presentation

Pyruvic acid methyl ester can be obtained by reacting pyruvic acid with methanol in the presence of p-toluenesulfonic acid.

properties

Pyruvic acid methyl ester is a colorless to yellowish liquid that is sparingly soluble in water.

use

Methyl pyruvate is used as an intermediate in the production of other chemical compounds (such as dimethyl 2,3-dimethylene butanedionate ). The compound has also been studied for use in cancer therapy.

safety instructions

The vapors of pyruvic acid methyl ester can form an explosive mixture with air ( flash point 39 ° C, ignition temperature 485 ° C).

Individual evidence

  1. a b c d e f g h i Entry on pyruvic acid methyl ester in the GESTIS substance database of the IFA , accessed on December 15, 2018(JavaScript required) .
  2. a b Data sheet Methyl pyruvate, 98% from AlfaAesar, accessed on December 15, 2018 ( PDF )(JavaScript required) .
  3. a b Data sheet methyl pyruvate, 90%, technical grade from Sigma-Aldrich , accessed on December 15, 2018 ( PDF ).
  4. Google Patents: CN105646208A - Preparation method of methyl pyruvate - Google Patents , accessed December 15, 2018
  5. ^ A. Weissberger and CJ Kibler: METHYL PYRUVATE. In: Organic Syntheses. 24, 1944, p. 72, doi : 10.15227 / orgsyn.024.0072 .
  6. Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy: Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy , accessed on 15 December 2018