Pyruvic acid methyl ester

Structural formula
General
Surname	Pyruvic acid methyl ester
other names	Methylpyruvate 2-oxopropionic acid methyl ester
Molecular formula	C 4 H 6 O 3
Brief description	colorless to yellowish liquid
External identifiers / databases
CAS number 600-22-6 EC number 209-987-4 ECHA InfoCard 100.009.081 PubChem 11748 ChemSpider 11255 Wikidata Q27122826
properties
Molar mass	102.09 g mol −1
Physical state	liquid
density	1.13 g cm −3
Melting point	−30 ° C
boiling point	137 ° C
solubility	poorly soluble in water soluble in chloroform , methanol , ether and ethanol
Refractive index	1.404 (20 ° C)
safety instructions
GHS labeling of hazardous substances Caution H and P phrases H: 226 P: 261
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

Pyruvic acid methyl ester is a chemical compound from the group of carboxylic acid esters .

Extraction and presentation

Pyruvic acid methyl ester can be obtained by reacting pyruvic acid with methanol in the presence of p-toluenesulfonic acid.

properties

Pyruvic acid methyl ester is a colorless to yellowish liquid that is sparingly soluble in water.

use

Methyl pyruvate is used as an intermediate in the production of other chemical compounds (such as dimethyl 2,3-dimethylene butanedionate ). The compound has also been studied for use in cancer therapy.

safety instructions

The vapors of pyruvic acid methyl ester can form an explosive mixture with air ( flash point 39 ° C, ignition temperature 485 ° C).

Individual evidence

1. ↑ ^{a b c d e f g h i} Entry on pyruvic acid methyl ester in the GESTIS substance database of the IFA , accessed on December 15, 2018(JavaScript required) .
2. ↑ ^{a b} Data sheet Methyl pyruvate, 98% from AlfaAesar, accessed on December 15, 2018 ( PDF )(JavaScript required) .
3. ↑ ^{a b} Data sheet methyl pyruvate, 90%, technical grade from Sigma-Aldrich , accessed on December 15, 2018 ( PDF ).
4. ↑ Google Patents: CN105646208A - Preparation method of methyl pyruvate - Google Patents , accessed December 15, 2018
5. ^ A. Weissberger and CJ Kibler: METHYL PYRUVATE. In: Organic Syntheses. 24, 1944, p. 72, doi : 10.15227 / orgsyn.024.0072 .
6. ↑ Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy: Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy , accessed on 15 December 2018