Candicidin

Structural formula
General
Surname	Candicidin
Molecular formula	C 59 H 84 N 2 O 18
Brief description	white solid
External identifiers / databases
EC number	215-763-7
ECHA InfoCard	100.014.330
DrugBank	DB01152
Wikidata	Q61653285
Drug information
ATC code	G01 AA04
properties
Molar mass	1109.32 g mol −1
Physical state	firmly
Melting point	150 ° C (decomposition)
solubility	almost insoluble in water and most organic solvents; soluble in DMSO, DMF and ethyl acetate;
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling ; no classification available
Toxicological data	14 mg kg −1 ( LD 50 , mouse , ip )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Candicidin is a four-component antibiotic. The main component, Candicidin D, is a chemical compound from the group of macrolides and heptaenes . Candicidin was first described by Lechevalier in 1953 and named after its action against Candida fungi.

Occurrence

Candicidin occurs naturally in Streptomyces griseus and other Streptomycetes .

properties

Candicidin is a white solid that is insoluble in water.

use

Candicidin is used as a fungicide against Candida albicans . It is not absorbed systemically and causes few toxic phenomena. Its effectiveness is still being investigated.

Individual evidence

^ ^A ^b ^c ^d ^e ^f G. WA Milne: Gardner's Commercially Important Chemicals Definitions, Trade Names, and Properties . John Wiley & Sons, 2005, ISBN 0-471-73661-9 , pp. 111 ( limited preview in Google Book search).
^ S. Huneck, Joachim Thiem: RÖMPP Lexikon Naturstoffe, 1st edition, 1997 . Georg Thieme Verlag, 2014, ISBN 3-13-179291-4 , p. 107 ( limited preview in Google Book search).
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ Patrizia Diana, Girolamo Cirrincione: Biosynthesis of Heterocycles From Isolation to Gene Cluster . John Wiley & Sons, 2015, ISBN 978-1-118-02867-4 , pp. 706 ( limited preview in Google Book search).
↑ ^a ^b TOKU-E: Candicidin - PRODUCT DATA SHEET ( Memento from April 8, 2014 in the Internet Archive ), accessed on September 5, 2015.
^ Josef Kimmig: Therapy of skin and sexually transmitted diseases . Springer-Verlag, 2013, ISBN 978-3-642-94850-3 , pp. 1263 ( limited preview in Google Book search).
↑ FH Meyers, E. Jawetz, A. Goldfien: Textbook of Pharmacology For students of medicine of all study stages and for doctors . Springer-Verlag, 2013, ISBN 978-3-642-66183-9 , p. 616 ( limited preview in Google Book search).

[G._W._A._Milne-1] A ^b ^c ^d ^e ^f G. WA Milne: Gardner's Commercially Important Chemicals Definitions, Trade Names, and Properties . John Wiley & Sons, 2005, ISBN 0-471-73661-9 , pp. 111 ( limited preview in Google Book search).

[S._Huneck,_Joachim_Thiem-2] S. Huneck, Joachim Thiem: RÖMPP Lexikon Naturstoffe, 1st edition, 1997 . Georg Thieme Verlag, 2014, ISBN 3-13-179291-4 , p. 107 ( limited preview in Google Book search).

[NV-3] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[Patrizia_Diana,_Girolamo_Cirrincione-4] Patrizia Diana, Girolamo Cirrincione: Biosynthesis of Heterocycles From Isolation to Gene Cluster . John Wiley & Sons, 2015, ISBN 978-1-118-02867-4 , pp. 706 ( limited preview in Google Book search).

[TOKU-E-5] TOKU-E: Candicidin - PRODUCT DATA SHEET ( Memento from April 8, 2014 in the Internet Archive ), accessed on September 5, 2015.

[und_Geschlechtskrankheiten-6] Josef Kimmig: Therapy of skin and sexually transmitted diseases . Springer-Verlag, 2013, ISBN 978-3-642-94850-3 , pp. 1263 ( limited preview in Google Book search).

[F.H._Meyers,_E._Jawetz,_A._Goldfien-7] FH Meyers, E. Jawetz, A. Goldfien: Textbook of Pharmacology For students of medicine of all study stages and for doctors . Springer-Verlag, 2013, ISBN 978-3-642-66183-9 , p. 616 ( limited preview in Google Book search).