Cefalonium

Structural formula
General
Non-proprietary name	Cefalonium
other names	(6 R , 7 R ) -3 - [(4-carbamoyl-1-pyridin-1-iumyl) methyl] -8-oxo-7 - [(1-oxo-2-thiophen-2-ylethyl) amino] - 5-thia-1-azabicyclo [4.2.0] oct-2-en-2-carboxylate ( IUPAC ); Cefalonium ( Latin );
Molecular formula	C 20 H 18 N 4 O 5 S 2
External identifiers / databases
EC number	226-948-7
ECHA InfoCard	100.024.499
PubChem	21743
ChemSpider	20438
DrugBank	DB11385
Wikidata	Q5057218
Drug information
Drug class	β-lactam antibiotic; 1st generation cephalosporins;
Mechanism of action	Disturbance of cell wall synthesis
properties
Molar mass	458.51 g · mol -1
Physical state	firmly
safety instructions
GHS labeling of hazardous substances	no GHS pictograms
	no GHS pictograms
H and P phrases	H: no H-phrases
	P: no P-phrases
Toxicological data	2750 mg kg −1 ( LD 50 , rat , ip )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Cefalonium is an antibiotic that is used in veterinary medicine . It is produced semisynthetically and belongs to the class of cephalosporins of the 1st generation.

indication

Cefalonium is mostly used in veterinary medicine. It has activity against aerobic Gram-positive and some community-acquired Gram-negative bacteria.

Cefalonium is used quarterly to treat subclinical infections and to prevent new infections intramammary during the dry season in cattle.

Cefalonium can also be used as an eye ointment for susceptible bacterial eye infections in cattle, including keratoconjunctivitis .

Working principle

The cefadroxil molecules bind to specific penicillin- binding proteins , which are located in the bacterial cell wall. This prevents further synthesis of the bacterial cell wall.

Trade names

Veterinary medicine

Cepravin Dry Cow (D)

Individual evidence

↑ ^a ^b ^c data sheet Cefalonium hydrate, VETRANAL at Sigma-Aldrich , accessed on May 26, 2019 ( PDF ).
↑ Entry on Cefalonium in the DrugBank of the University of Alberta , accessed on May 22, 2019.
↑ CEFALONIUM. Retrieved May 27, 2019 .
↑ vetion.de: Declaration "intramammary" ( Memento from March 22, 2015 in the Internet Archive )
^ Cefalonium. Comitee for veterinary medicinal products, August 1999, accessed May 20, 2019 .
↑ Gunter Schmidt: Cephalosporins . In: Chemistry in Our Time . tape 10 , no. 6 , 1976, p. 189-195 , doi : 10.1002 / ciuz.19760100605 .

[Sigma-1] ta sheet Cefalonium hydrate, VETRANAL at Sigma-Aldrich , accessed on May 26, 2019 ( PDF ).

[2] Entry on Cefalonium in the DrugBank of the University of Alberta , accessed on May 22, 2019.

[3] CEFALONIUM. Retrieved May 27, 2019 .

[4] vetion.de: Declaration "intramammary" ( Memento from March 22, 2015 in the Internet Archive )

[5] Cefalonium. Comitee for veterinary medicinal products, August 1999, accessed May 20, 2019 .

[6] Gunter Schmidt: Cephalosporins . In: Chemistry in Our Time . tape 10 , no. 6 , 1976, p. 189-195 , doi : 10.1002 / ciuz.19760100605 .