Christoph Handschin
Christoph Handschin (born February 20, 1973 in Basel ) is a Swiss cell biologist and professor at the Biozentrum of the University of Basel .
Life
Christoph Handschin studied biology at the University of Basel. He then did his doctorate in the group of Urs A. Meyer in the field of biochemistry at the Biozentrum of the University of Basel. Between 2002 and 2006 Christoph Handschin conducted research at the Dana-Farber Cancer Institute and the Harvard Medical School in Boston , USA, before he was appointed Assistant Professor of Physiology and SNSF Professor at the University of Zurich in 2006 . In 2009 Christoph Handschin returned to the Biozentrum of the University of Basel, where he has been researching and teaching as Professor of Pharmacology ever since .
Act
Christoph Handschin researches the molecular processes that underlie trained or diseased muscles . The focus of his research is the protein PGC-1α , which has a significant influence on metabolism and muscle function. Christoph Handschin was able to prove that PGC-1 α centrally controls the adaptation mechanisms of the muscle during endurance training. PGC-1α increases the endurance of the muscle by regulating the formation and breakdown of lactate , among other things . Handschin also found that increased PGC-1α production has a therapeutic effect on muscle wasting and dystrophy . His results provide concrete approaches for the therapy of muscle diseases or age-related muscle wasting.
Awards
- 2013: European Research Council ERC Consolidator Grant
- 2008: Science Prize from the Walter and Gertrud Siegenthaler Foundation
- 2006: SNSF professorship from the Swiss National Science Foundation
- 2004: Scientist Career Development Award, Muscular Dystrophy Association USA (MDA)
Publications (selection)
- S. Summermatter, G. Santos, J. Pérez-Schindler, C. Handschin: Skeletal muscle PGC-1α controls whole body lactate homeostasis through ERRα-dependent activation of LDH B and repression of LDH A. In: Proc Natl Acad Sci USA. 110 (21), 2013, pp. 8738-8743.
- C. Handschin, YM Kobayashi, S. Chin, P. Seale, KP Campbell, BM Spiegelman: PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. In: Genes Dev. 21 (7), 2007, pp. 770-783.
- C. Handschin, J. Lin, J. Rhee, AK Peyer, S. Chin, PH Wu, UA Meyer, BM Spiegelman: Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1α. In Cell. 122 (4), 2005, pp. 505-515.
Web links
- Research group Christoph Handschin at the Biozentrum of the University of Basel
Individual evidence
- ↑ Curriculum Vitae
- ^ Research group
- ↑ 10 million for research: University of Basel receives four ERC Consolidator Grants. In: University of Basel from December 12, 2013
- ↑ Science Prize of the Walter and Gertrud Siegenthaler Foundation 2008
- ↑ SNSF professorships (PDF; 511 kB)
- ↑ List of publications
| personal data | |
|---|---|
| SURNAME | Handschin, Christoph |
| BRIEF DESCRIPTION | Swiss cell biologist and professor at the Biozentrum of the University of Basel |
| DATE OF BIRTH | 20th February 1973 |
| PLACE OF BIRTH | Basel |