David Domingo Sabatini
David Domingo Sabatini (born May 10, 1931 in Bolivar, Argentina ) is an Argentine-American cell biologist .
Sabatini studied medicine at the Universidad Nacional del Litoral in Santa Fe with the degree in 1954 and then researched with Eduardo De Robertis at the University of Buenos Aires , where he was an instructor and assistant professor of histology . In 1961 he went to the USA as a Rockefeller Fellow at Rockefeller University in New York, where he received his doctorate (Ph. D.) in 1966 and was an assistant professor of cell biology. He was also in 1961 for a research stay at Yale. In 1972 he became a professor and in 1975 he became Frederick L. Ehrman Professor of Cell Biology at New York University and head of the Cell Biology Department.
In the 1960s, he discovered the fixation of cell structures with glutaraldehyde for examinations under the electron microscope, which enabled the discovery of new subcellular structures such as microtubules and the localization of enzyme activities in certain organelles.
Also in the 1960s began his study of protein transport during and after synthesis in the ribosomes of the endoplasmic reticulum , which led to the formulation of the signal hypothesis for protein transport with Günter Blobel (1971), namely the role of certain signal sequences on the proteins that cause transport control (see protein biosynthesis ). As a result, he researched these processes in detail in his laboratory.
At the end of the 1970s, together with visiting professor Marcelino Cerijido, he introduced the MDCK cell line to study the polar nature of epithelial cells . With Enrique Rodriguez-Boulan he investigated the budding mechanism of viruses on the cell surfaces of epithelial cells. From 1978 to 1979 he was President of the American Society for Cell Biology .
He should not be confused with the American molecular biologist David M. Sabatini .
Awards and memberships (selection)
- 1984: Keith R. Porter Lecture
- 1986: EB Wilson Medal with Günter Blobel
- 1988: Prix Charles-Léopold Mayer
- 1980: Admission to the American Academy of Arts and Sciences
- 1985: Admission to the National Academy of Sciences
- 1992: Admission to the Académie des Sciences
- 2000: Admission to the American Philosophical Society
- 2000: Admission to the National Academy of Medicine
- 2003: Grande médaille de l'Académie des sciences
- 2009: Admission to the American Association for the Advancement of Science
He is a Knight of the Legion of Honor .
Web links
Individual evidence
- ↑ Life data according to American Men and Women of Science , Thomson Gale 2004
| personal data | |
|---|---|
| SURNAME | Sabatini, David Domingo |
| BRIEF DESCRIPTION | Argentine-American molecular biologist |
| DATE OF BIRTH | May 10, 1931 |
| PLACE OF BIRTH | Bolivar, Argentina |