Dehydrochloromethyltestosterone

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Structural formula
Structure of dehydrochloromethyltestosterone
General
Non-proprietary name Chlorodehydromethyltestosterone
other names
  • 4-chloro-17 β -hydroxy-17 α -methylandrosta-1,4-dien-3-one
  • (8 R , 9 S , 10 R , 13 S , 14 S , 17 S ) -4-chloro-17-hydroxy-10,13,17-trimethyl-7,8,9,11,12,14,15, 16-octahydro-6 H -cyclopenta [ a ] phenanthren-3-one ( IUPAC )
Molecular formula C 20 H 27 ClO 2
External identifiers / databases
CAS number 2446-23-3
PubChem 98521
ChemSpider 88972
Wikidata Q909987
Drug information
ATC code

A14 AA10

Drug class

Anabolic steroid

properties
Molar mass 334.88 g · mol -1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Chlorodehydromethyltestosterone is in the 1960 years in the pharmaceutical factory VEB Jenapharm in the GDR developed and sold under the trade names Oral-Turinabol marketed anabolic steroid . In the 1970s and 1980s, it was administered on a large scale in state-organized forced doping in competitive GDR sports, particularly in the strength disciplines such as the shot put , discus throwing , sprint disciplines and swimming .

The prescription drug was available in two forms, pink tablets, each containing one milligram of active ingredient, and blue tablets (known among competitive athletes as blue beans or blue flashes ), each containing five milligrams of active ingredient.

Active ingredient and effect

Dehydrochloromethyltestosterone is an artificial male sex hormone with a strong anabolic and a relatively low androgenic active component (anabolic effect: 53, androgenic effect: 6 according to measurements with the Hershberger test ). The drug was originally developed to aid healing after severe injuries and operations, including a. it was prescribed for bone loss. It causes the muscles to grow rapidly , which led to high performance increases, especially in young athletes.

Side effects

Overdosing or long-term use can lead to severe liver damage , significant high blood pressure, muscle cramps and increased aggressiveness. Possible side effects in women include a deeper voice, beard growth, acne , an increase in libido , infertility, and menstrual disorders . Potency disorders and prostate diseases can occur in men . The administration of dehydrochloromethyltestosterone to children is particularly problematic, since they are still in the growth phase and therefore growth disorders can easily occur.

commitment

Oral-Turinabol pack ( DDR Museum Berlin )

In 1968, GDR sports officials decided to administer dehydrochloromethyltestosterone to athletes. Due to the success of doped athletes at the 1968 Olympic Games in Mexico, it was widely used a little later. From 1974 onwards, dehydrochloromethyltestosterone was administered to girls and women in the GDR sports performance centers. A secret working group was formed in 1974 under the supervision of the Sports Medical Service to distribute the drug . Oral-Turinabol has already been given to athletes from the age of thirteen.

Jenapharm stopped production in 1994 because of the liver-damaging effects. Oral-Turinabol ® is now available on the black market again, the active ingredient is still being manufactured, including in laboratories in China.

Around 100 to 160 former GDR athletes who were harmed by taking Oral-Turinabol and other performance-enhancing substances made claims for damages in 2004 against the Jenapharm company, which is now part of the Bayer Group.

literature

Individual evidence

  1. This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. Brigitte Berendonk: Doping documents - From research to fraud. Springer-Verlag, Berlin 1991, ISBN 3-540-53742-2 , p. 80.
  3. Орал Туринабол: описание препарата, как принимать (КУРС), история, отзывы. Retrieved October 10, 2018 (ru-RU).
  4. Doping with Oral-Turinabol taz, December 19, 2001, p. 3.
  5. ^ GDR doping agents on the black market Berliner Zeitung, March 17, 2003, p. 32.
  6. Nine doping cases - Azerbaijan has to pay. Frankfurter Allgemeine Zeitung , April 1, 2014, accessed on August 2, 2014 .
  7. ( Page no longer available , search in web archives: Jenapharm rejects claims by GDR athletes. ) Arge.sportgericht.de, July 15, 2004.@1@ 2Template: Toter Link / arge.sportgericht.de
  8. ( Page no longer available , search in web archives: GDR doping victims are suing DOSB and Jenapharm for damages. ) Sports law working group of the German Lawyers' Association.@1@ 2Template: Toter Link / arge.sportgericht.de