Dennis J. Slamon

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Dennis Joseph Slamon (born August 6, 1948 in New Castle , Pennsylvania ) is an American oncologist and professor at the University of California, Los Angeles .

Life

Slamon earned a bachelor's degree in biology from Washington & Jefferson College in Washington , Pennsylvania in 1970 and an MD from the University of Chicago in Chicago , Illinois in 1975 , and Ph.D. from Winston Anderson and Werner Kirsten. in cell biology . From 1975 to 1978 Slamon worked as an assistant doctor at the University of Chicago Hospitals and Clinics , from 1978 to 1979 as chief resident . In 1978 he acquired the specialist for internal medicine ( internist ), in 1982 as a specialist in oncology . Since 1979 Slamon has been working in the hematology / oncology department at the University of California, Los Angeles School of Medicine , first as a fellow , then as a professor (1982 Adjunct Assistant Professor , 1984 Assistant Professor , 1988 Associate Professor , 1993 Full Professor).

Since 2013 Thomson Reuters has counted him among the favorites for a Nobel Prize ( Thomson Reuters Citation Laureates ) due to the number of his citations .

Slamon is married.

Act

Slamon's most important works concern the HER2 / neu receptor, an epidermal growth factor receptor that is found strongly on the tumor cells of around 20% of breast cancer patients , and the monoclonal antibody trastuzumab (trade name Herceptin), which is directed against HER2 / neu, which stimulates the growth of these Inhibits cells. Slamon's work is a particularly important example of the rapid clinical application of the results of basic research . Herceptin represents a paradigm shift in cancer therapy in that for the first time a chemotherapeutic agent could be developed specifically against specific properties of certain subgroups of tumors.

Slamon's life and his efforts to research the HER2 / neu receptor and the possibility of treatment with Herceptin were filmed in the 2008 television film Living proof with Harry Connick junior in the lead role.

Awards (selection)

literature

Web links

Individual evidence

  1. 2013 Predictions at Thomson Reuters (sciencewatch.com); Retrieved September 25, 2013
  2. Living Proof in the Internet Movie Database (English)
  3. American Cancer Society Presents 2004 Medal of Honor Awards ( Memento of the original from November 10, 2011 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. at charitywire.com; Retrieved June 9, 2011 @1@ 2Template: Webachiv / IABot / www.charitywire.com
  4. Oncology Luminary: Dr. Dennis Slamon - CancerProgress.Net. In: cancerprogress.net. September 29, 2014, accessed February 6, 2016 .
  5. ^ Dennis J. Slamon MD, PhD at the Gairdner Foundation ; Retrieved December 15, 2012