Detlef Schuppan

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Detlef Schuppan (born August 9, 1954 in Essen , Ruhr) is a German biochemist and physician whose scientific and clinical focus is a. a. in the diagnosis and therapy of celiac disease and wheat sensitivity , fibrosing liver diseases and the immunology of tumor and chronic diseases. Schuppan is head of the Institute for Translational Immunology and University Professor for Internal Medicine / Gastroenterology / Hepatology at Johannes Gutenberg University Mainz . Among other things, he heads the outpatient clinic for celiac and small bowel diseases. He is also a full professor and senior visiting scientist at Harvard Medical School in Boston, USA.

Life

The son of a judge studied chemistry at the Ludwig Maximilians University (LMU) Munich and human medicine at the LMU Munich, the Philipps University of Marburg and the Free University (FU) Berlin . In 1982 he received his doctorate at the Max Planck Institute for Biochemistry in Martinsried near Munich (structure elucidation of basement membrane collagen). In 1986 he received his license to practice medicine at the Free University of Berlin. In 1989 he received his doctorate in medicine with summa cum laude (discovery and characterization of undulin / collagen type XIV), the habilitation in biochemistry (FU Berlin) in 1992 and four years later the habilitation in internal medicine.

He acquired a specialist in internal medicine (1993) and gastroenterology (1996). From 1997 to 2004 he worked as a university professor, senior physician and deputy director at the Medical Clinic I of the Friedrich-Alexander University Erlangen-Nuremberg . From 2004 to 2010 he was an associate and later a full professor of medicine and clinical consultant for gastroenterology and hepatology at the Beth Israel Deaconess Medical Center (BIDMC) of the Harvard Medical School in Boston, USA. In 2011 he became Director of the Celiac Disease and Fibrosis Center of the University Medicine, Johannes Gutenberg University (JGU) Mainz and Senior Visiting Scientist at BIDMC, Harvard Medical School. Since 2013 he has been director of the Institute for Translational Immunology (JGU Mainz).

Schuppan held guest professorships at Columbia University (New York), Yale University (New Haven), Duke University (Durham), University of Maryland , Mayo Clinic (Rochester), Weizmann Institute (Rehovot, Israel), from the University of California in Los Angeles and in San Diego .

Schuppan is married and has three daughters and one son.

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His clinical-scientific focus is the elucidation of the cellular and molecular mechanisms of chronic inflammatory diseases, especially the translation of these findings into clinical practice. This includes the development of new diagnostics and specific therapies for

  1. Inflammatory and fibrosing diseases of the liver ( liver cirrhosis ) and the intestine, but also other organs;
  2. Celiac disease , non-celiac disease / non-allergy gluten sensitivity (correct: wheat sensitivity) and related autoimmune and systemic diseases ;
  3. the role of the immune system in the defense against tumor diseases, particularly of the liver and gastrointestinal tract, and
  4. the role of nutrition in autoimmune diseases and diseases of the metabolic syndrome , especially fatty liver hepatitis and type 2 diabetes. The focus here is on the development of targeted and individualized therapies, including those based on therapeutic nanoparticles as a carrier system for pharmaceuticals, combined with specific biomarker development .

Outstanding performance

  • 1990 Discovery of fibril-associated collagen XIV (undulin)
  • 1997 Identification of tissue transglutaminase (TG2) as an autoantigen of celiac disease, thus a paradigm shift in celiac disease research and, for the first time, reliable diagnosis of the disease
  • 2012 Discovery of the amylase trypsin inhibitors (ATI) from wheat as the cause of non-celiac disease / non-allergy wheat sensitivity, thus paradigm shift in research on "gluten sensitivity"
  • Development of serum biomarkers of immune cell-specific inflammatory activity (microparticles) and of serum protein markers of liver fibrosis progression, as well as antifibrotically effective drugs, which in combination with the biomarkers form the basis for the clinical development of effective antifibrotic therapies for liver fibrosis and fibrosis of others Create organs.

Publications

Schuppan is the author of more than 70 book articles and more than 400 scientific publications listed in PubMed .

He is the editor of several medical science books and is an associate editor of high-profile journals such as Gastroenterology , Journal of Hepatology , American Journal of Physiology, and the Journal of Clinical Investigation. Since 2011 he has been chairman of the scientific advisory board of the German Celiac Society . As a full professor of medicine at Harvard Medical School and as a German university professor, Schuppan is the only German doctor and scientist to practice leading positions in both university systems.

Awards and memberships

Prizes and awards

  • 1990: Lucie Bolte Promotion Award for liver research
  • 1994: Hermann-und-Lilly-Schilling-Professorship, Dept. of Gastroenterology, Benjamin Franklin Hospital, Free University of Berlin
  • 2004: Zetzel Visiting Professor, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
  • 2010: Gutenberg Research College, University of Mainz
  • 2011: ERC Advanced Grant Fibroimaging (Quantitative imaging of liver fibrosis and fibrogenesis)

Memberships

  • German Society for the Study of the Liver (GASL)
  • European Society for the Study of the Liver (EASL)
  • United States Society for the Study of Liver Diseases (AASLD)
  • German Society for Digestive and Metabolic Diseases (DGVS)
  • European Gastroenterologists Association (UEGF)
  • United States Gastroenterologists Association (AGA)
  • United States Physiological Society (APA)
  • Research Center Immunotherapy, University Medical Center Mainz (FZI)

Web links

Individual evidence

  1. ↑ Johannes Gutenberg University Mainz: Nanodimensional polymer therapeutics for tumor therapy. Retrieved July 11, 2014
  2. ^ W. Dieterich, E. Laag, H. Schöpper, U. Volta, A. Ferguson, H. Gillett, EO Riecken, D. Schuppan: Autoantibodies to tissue transglutaminase as predictors of celiac disease . In: Gastroenterology . 115, No. 6, December 1998, pp. 1317-1321. doi : 10.1016 / S0016-5085 (98) 70007-1 . PMID 9834256 .
  3. Jump up ↑ W. Dieterich, T. Ehnis, M. Bauer, P. Donner, U. Volta, EO Riecken, D. Schuppan: Identification of tissue transglutaminase as the autoantigen of celiac disease . In: Nat Med . 3, No. 7, July 1997, pp. 797-801. doi : 10.1038 / nm0797-797 . PMID 9212111 .
  4. ^ Y. Junker, S. Zeissig, SJ Kim, D. Barisani, H. Wieser, DA Leffler, V. Zevallos, TA Libermann, S. Dillon, TL Freitag, CP Kelly, D. Schuppan: Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4 . In: JEM . 209, No. 13, December 2012, pp. 2395-2408. doi : 10.1084 / jem.20102660 . PMID 23209313 .
  5. ^ ARD Mittagsmagazin: Article: Protein "ATI" in wheat makes you sick. Retrieved July 11, 2014
  6. ^ M. Kornek, Y. Popov, TA Libermann, NH Afdhal, D. Schuppan: Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells . In: Hepatology . 53, No. 1, January 2011, pp. 230-242. doi : 10.1002 / hep.23999 . PMID 20979056 .
  7. ↑ M. Kornek, M. Lynch, SH Mehta, M. Lai, M. Exley, NH Afdhal, D. Schuppan: Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis . In: Gastroenterology . 143, No. 2, August 2012, pp. 448-458. doi : 10.1053 / j.gastro.2012.04.031 . PMID 22537612 .
  8. ^ PubMed: Scientific publications Schuppan. Retrieved July 11, 2014
  9. ↑ German Celiac Society: Members of the Scientific Advisory Board. ( Memento of the original from July 24, 2014 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. Retrieved July 11, 2014 @1@ 2Template: Webachiv / IABot / www.dzg-online.de
  10. ↑ Johannes Gutenberg University Mainz: ERC Advanced Grant Fibroimaging Accessed on July 11, 2014
  11. ^ Membership list of the FZI. Retrieved July 11, 2014
personal data
SURNAME Schuppan, Detlef
BRIEF DESCRIPTION German biochemist and physician
DATE OF BIRTH August 9, 1954
PLACE OF BIRTH eat