Difethialone

from Wikipedia, the free encyclopedia
Structural formula
Structural formula of difethialone
Structural formula without specifying the stereochemistry
General
Surname Difethialone
other names

3- [3- (4'-bromo [1,1'-biphenyl] -4-yl) -1,2,3,4-tetrahydronaphth-1-yl] -4-hydroxy-2 H -1-benzothiopyran- 2-on

Molecular formula C 31 H 23 BrO 2 S
Brief description

white to yellow, odorless powder

External identifiers / databases
CAS number 104653-34-1
EC number 600-594-7
ECHA InfoCard 100.118.383
PubChem 91771
Wikidata Q424845
properties
Molar mass 539.49 g mol −1
Physical state

firmly

density

1.36 g cm −3

Melting point

235 ° C

Vapor pressure

0.0133 mPa (25 ° C)

solubility
  • practically insoluble in water (0.0004 g l −1 at 20 °)
  • soluble in dichloromethane (14 g l −1 at 20 ° C)
safety instructions
GHS hazard labeling from  Regulation (EC) No. 1272/2008 (CLP) , expanded if necessary
06 - Toxic or very toxic 08 - Dangerous to health 09 - Dangerous for the environment

danger

H and P phrases H: 300-310-330-360D-372-410
EUH: 070
P: ?
Toxicological data

0.56 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Difethialon is a mixture of four isomeric chemical compounds from the group of thiocoumarins that is used as a rodenticide and is structurally similar to warfarin . It is a water-insoluble, white to yellow powder.

use

Difethialon is a second generation anticoagulant that was introduced in 1986. It is mainly used to control mice and rats indoors as well as in warehouses and stables. It may only be used in secured bait boxes and not as a contact powder. Poisoned animals must not be allowed outside. Resistance to difethialone has not yet become known. It is very poisonous to humans, as well as to most higher animal species. Secondary poisoning of domestic and wild animals is possible when eating dead rodents. In the event of accidental ingestion, therapy with vitamin K preparations must be carried out under medical supervision.

Admission

In the US, its use has been banned since an EPA decision in May 2008. In Germany, approval has been limited to October 31, 2014 since it was included in the table in Annex I of Directive 98/8 / EC on November 1, 2009. The time limit was extended to June 30, 2024 in 2017.

Web links

Individual evidence

  1. ↑ a b c d e f g Entry on Difethialone in the Pesticide Properties DataBase (PPDB) of the University of Hertfordshire , accessed on January 7, 2014.
  2. ^ Entry on difethialon in the GESTIS substance database of the IFA , accessed on September 27, 2018(JavaScript required) .
  3. ↑ Entry on difethialone (ISO); 3- [3- (4'-bromobiphenyl-4-yl) -1,2,3,4-tetrahydronaphthalen-1-yl] -4-hydroxy-2H-1-benzothiopyran-2-ones in the Classification and Labeling Inventory of European Chemicals Agency (ECHA), accessed on June 17, 2017. Manufacturers or distributors can expand the harmonized classification and labeling .
  4. ^ Robert Irving Krieger, Handbook of Pesticide Toxicology: Principles. ISBN 978-0-1242-6260-7 , p. 1822.
  5. ^ EPA: Risk Mitigation Decision for Ten Rodenticides
  6. ↑ Amendment of Directive 98/8 / EC of the European Parliament and of the Council to include the active substance difethialon in Appendix I (PDF)
  7. ↑ IMPLEMENTING REGULATION (EU) 2017/1382 OF THE COMMISSION of 25 July 2017 on the renewal of the approval for difethialone as an active ingredient for use in biocidal products of product type 14 , accessed on 25 September 2018